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ALX-340-004
Revised 18-Aug-08
Arachidonic acid
SYNONYMS
5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Arachidonic Acid / Related Products
Ordering Information
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Format:
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Unit Price:
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ALX-340-004-M100
100 mg
147.00 USD
Product Specification
FORMULA:
C
20
H
32
O
2
MW:
304.5
CAS NUMBER:
506-32-1
MERCK INDEX:
14:
765
RTECS:
CE6675000
CONCENTRATION:
100mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY:
100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
HAZARD:
TOXIC.
Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism:
P. Needleman, et al.; Ann. Rev. Biochem.
55
, 69 (1986)
Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid:
M.D. Lister, et al.; J. Biol. Chem.
263
, 7506 (1988)
Abstract
;
Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets:
M.W. Radomski, et al.; Br. J. Pharmacol.
101
, 325 (1990)
Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor:
A.J.R. Habenicht, et al.; Nature
345
, 634 (1990)
Abstract
The control of free arachidonic acid levels:
R.D. Burgoyne & A. Morgan; TIBS
15
, 365 (1990)
Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets:
F. Chevy, et al.; Lipids
26
, 1080 (1991)
Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids:
J.W. Han, et al.; Science
252
, 576 (1991)
Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils:
S.B. Abramson, et al.; J. Immunol.
147
, 231 (1991)
Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation:
Henderson, et al.; Eur. J. Biochem.
211
, 157 (1993)
Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia:
G. Khurana & M.R. Bennett; Br. J. Pharmacol.
109
, 480 (1993)
Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum:
C. Dettbarn & P. Palade; Biochem. Pharmacol.
45
, 1301 (1993)
Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets:
H. Hallak, et al.; J. Biol. Chem.
269
, 4713 (1994)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators
•
Nitric Oxide Pathway Other Products
•
Fatty Acids
ALX-350-005
Revised 02-Oct-07
Bryostatin 1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
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ALX-350-005-C010
10 µg
85.00 USD
Product Specification
FORMULA:
C
47
H
68
O
17
MW:
905.0
CAS NUMBER:
83314-01-6
MERCK INDEX:
14:
1457
PURITY:
≥97%
APPEARANCE:
Colorless oil.
SOLUBILITY:
25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed. Binds to glass and plastic surfaces in aqueous solutions.
Product Description
Binds to and activates protein kinase C (PKC). Antineoplastic.
Product Specific Literature References
Isolation and structure of Bryostatin 1:
G.R. Pettit, et al.; J. Am. Chem. Soc.
104
, 6846 (1982)
Bryostatin 1: differentiating agent from the depths
:
R.M. Stone; Leuk. Res.
21
, 399 (1997)
Abstract
Chemistry and clinical biology of the bryostatins
:
R. Mutter & M. Wills; Bioorg. Med. Chem.
8
, 1841 (2000), (Review)
Abstract
The clinical development of the bryostatins
:
A. Clamp and G.C. Jayson; Anticancer Drugs
13
, 673 (2002)
Abstract
The chemistry and biology of the bryostatin antitumour macrolides
:
K.J. Hale, et al.; Nat. Prod. Rep.
19
, 413 (2002), Review
Abstract
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug:
M.K. Sun & D.L. Alkon; CNS Drug Rev.
12
, 1 (2006), Review
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers)
•
PKC Activators
•
Natural Products - Immunomodulators
•
Natural Products - Antitumor Reagents
ALX-370-009
Revised 26-Jun-06
Cholesterol 3-sulfate . sodium salt
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Cholesterol & Lipid Transport / Related Products
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ALX-370-009-M005
5 mg
20.00 USD
ALX-370-009-M025
25 mg
45.00 USD
Product Specification
FORMULA:
C
27
H
45
O
4
S . Na
MW:
465.7 . 23.0
CAS NUMBER:
2864-50-8
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.
Product Specific Literature References
Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C:
T. Ikuta, et al.; Cell Growth Differentiation
5
, 943 (1994)
Abstract
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes
:
M.F. Denning, et al.; Cell Growth Differentiation
6
, 1619 (1995)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-270-261
Revised 14-May-03
(2S,5S)-8-Decylbenzolactam V
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Activators
Ordering Information
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ALX-270-261-C500
500 µg
125.00 USD
Product Specification
FORMULA:
C
25
H
42
N
2
O
2
MW:
402.6
PURITY:
≥95%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of protein kinase C (PKC) with improved selectivity for the α, β and γ isoforms.
Product Specific Literature References
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta:
A.P. Kozikowski, et al.; J. Med. Chem.
40
, 1316 (1997)
Abstract
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator:
S. Bhagavan, et al.; Neurobiol. Dis.
5
, 177 (1998)
Abstract
ALX-445-049
Revised 24-Oct-07
12-Deoxyphorbol 13-phenylacetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-049-M005
5 mg
220.00 USD
Product Specification
FORMULA:
C
28
H
34
O
6
MW:
466.6
CAS NUMBER:
58821-98-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO and ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
POTENTIAL TUMOR PROMOTER. IRRITANT.
Product Description
Metabolite of 12-deoxyphorbol 13-phenylacetate 20-acetate. Potent activator of protein kinase C (PKC). Induces the expression of HIV-1 in latently infected T cells.
Product Specific Literature References
Role of protein kinase C isozymes in activation of human immunodeficiency virus type 1 in chronically infected promonocytic cells: evidence against a role of PKC beta 1:
C.H. Kim, et al.; Biochem. Biophys. Res. Commun.
199
, 292 (1994)
Abstract
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes:
Z. Szallasi, et al.; Mol. Pharmacol.
47
, 258 (1995)
Abstract
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate:
S. Bocklandt, et al.; Antiviral Res.
59
, 89 (2003)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-430-027
Revised 05-Dec-04
Diacylglycerol Kinase Inhibitor I (R59 022)
SYNONYMS
6-[2-(4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl)ethyl]-7-methyl-5
H
-thiazolo-[3,2-a]pyrimidine-5-one
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Diacylglycerol Kinases / Related Products
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ALX-430-027-M005
5 mg
115.00 USD
Product Specification
FORMULA:
C
27
H
26
FN
3
OS
MW:
459.6
CAS NUMBER:
93076-89-2
PURITY:
≥99%
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO, THF or DMF. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potentiates the activity of protein kinase C (PKC) by inhibiting the diacylglycerol metabolism. Inhibits diacylglycerol kinase without affecting phosphodiesterase or phosphatidyl inositol kinase.
Product Specific Literature References
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet:
D. de Chaffoy de Courcelles, et al.; J. Biol. Chem.
260
, 15762 (1985)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Activators
ALX-300-052
Revised 16-Apr-05
1,2-Dioctanoyl-sn-glycerol
SYNONYMS
DOG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
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ALX-300-052-M010
10 mg
30.00 USD
ALX-300-052-M050
50 mg
90.00 USD
ALX-300-052-M100
100 mg
150.00 USD
Product Specification
FORMULA:
C
19
H
36
O
5
MW:
344.5
CAS NUMBER:
60514-48-9
PURITY:
≥98%
APPEARANCE:
Clear colorless liquid.
SOLUBILITY:
Soluble in DMSO or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
At room temperature DOG is an oil. Due to its instability, keep it cool and dry.
Product Description
Potent activator of protein kinase C (PKC).
Product Specific Literature References
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C:
P.M. Conn, et al.; BBRC
126
, 532 (1985)
Abstract
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis:
R.J. Davis, et al.; J. Biol. Chem.
260
, 1562 (1985)
Abstract
;
Full Text
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation:
J.G. Ebeling, et al.; PNAS
82
, 815 (1985)
Abstract
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine:
Y.A. Hannun, et al.; J. Biol. Chem.
260
, 10039 (1985)
Abstract
;
Full Text
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets:
E.G. Lapetina, et al.; J. Biol. Chem.
260
, 1358 (1985)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Activators
ALX-340-037
Revised 08-Jul-08
8(S)-HETE
SYNONYMS
8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
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ALX-340-037-C025
25 µg
165.00 USD
Product Specification
FORMULA:
C
20
H
32
O
3
MW:
320.5
CAS NUMBER:
98462-03-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin:
M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta
1081
, 347 (1991)
Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites:
H.H. Lo, et al.; Lipids
29
, 547 (1994)
Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids:
K. Yu, et al.; J. Biol. Chem.
270
, 23975 (1995)
Abstract
;
Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans:
Y. Guan, et al.; Am. J. Physiol.
273
, F1013 (1997)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
•
PKC Activators
ALX-420-011
Revised 12-Jan-07
(-)-Indolactam V
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Activators
Ordering Information
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Format:
Size:
Unit Price:
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ALX-420-011-C300
300 µg
110.00 USD
ALX-420-011-M001
1 mg
250.00 USD
Product Specification
FORMULA:
C
17
H
23
N
3
O
2
MW:
301.4
CAS NUMBER:
90365-57-4
RTECS:
UY8547000
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
HARMFUL. MAY BE CARCINOGENIC.
IDENTITY:
May contain traces of (+)-Indolactam V.
Product Description
Moderately potent indolactam activator of protein kinase C (PKC). Increases cytoplasmic mRNAs.
Product Specific Literature References
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin:
H. Fujiki, et al.; Gann
75
, 866 (1984)
Abstract
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells:
J. Heikkilä & K. Akerman; BBRC
162
, 1207 (1989)
Abstract
Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways:
C.E. Lee, et al.; Cell Immunol.
146
, 171 (1993)
Abstract
Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay:
H.L. Shieh, et al.; Mol. Carcinogen.
12
, 166 (1995)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
ALX-350-031
Revised 07-Apr-08
Ingenol (high purity)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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Format:
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Unit Price:
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ALX-350-031-M001
1 mg
45.00 USD
ALX-350-031-M005
5 mg
195.00 USD
Product Specification
FORMULA:
C
20
H
28
O
5
MW:
348.4
CAS NUMBER:
30220-46-3
PURITY:
≥98%
APPEARANCE:
Solid.
SOLUBILITY:
Soluble in DMSO and 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Extremely weak protein kinase C (PKC) activator. Starting material for synthesis of ingenol derivatives.
Product Specific Literature References
Specific binding to protein kinase C by ingenol and its induction of biological responses:
C.M. Hasler, et al.; Cancer Res.
52
, 202 (1992)
Abstract
Preconditioning of isolated rabbit cardiomyocytes: effects of glycolytic blockade, phorbol esters, and ischaemia:
S. Armstrong & C.E. Gonote; Cardiovasc. Res.
28
, 1700 (1994)
Abstract
Total synthesis of ingenol:
I. Kuwajima & K. Tanino; Chem. Rev.
105
, 4661 (2005), (Review)
Abs
