• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Na+ Channels
You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products > Na+ Channels
Toolbar - View Selection
 
 Items 20-24 of 24 Page 2 of 2 Select Page: << 1 2   
ALX-550-344 Revised 29-Jan-05
Riluzole
Add to Clipboard
SYNONYMS 2-Amino-6-(trifluoromethoxy)-benzothiazole
6-(Trifluoromethoxy)-2-benzothiazolamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ Channels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-344-M010   10 mg 20.00 USD Add To Cart
ALX-550-344-M050   50 mg 60.00 USD Add To Cart
ALX-550-344-M500   500 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C8H5F3N2OS
MW: 234.2
CAS NUMBER: 1744-22-5
MERCK INDEX: 14: 8223
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO (>40mg/ml), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (14mg/ml) or in 0.1N HCl (11mg/ml). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Glutamate release inhibitor. Neuroprotective. Blocks the inactivated state of voltage-gated neuronal Na+ channels at very low concentrations (about 0.1µM).
Product Specific Literature References
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia: J. Pratt, et al.; Neurosci. Lett. 140, 225 (1992) Abstract
Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission: J. Mantz, et al.; Anesthesiology 76, 844 (1992) Abstract
Effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on striatal neurochemical markers in the rat, with special reference to the dopamine, choline, GABA and glutamate synaptosomal high affin: D. Samuel, et al.; Fundam. Clin. Pharmacol. 6, 177 (1992) Abstract
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study: A. Benazzouz, et al.; Eur. J. Pharmacol. 284, 299 (1995) Abstract
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures: A.G. Estevez, et al.; Eur. J. Pharmacol. 280, 47 (1995) Abstract
Na+ channels as targets for neuroprotective drugs: C.P. Taylor & B.S. Meldrum; TIPS 16, 309 (1995), (Review) Abstract
Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurons: M. Umemiya & A.J. Berger; Br. J. Pharmacol. 116, 3227 (1995) Abstract
Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats: M.C. Guyot, et al.; Neuroscience 81, 141 (1997) Abstract
Further Categories Containing This Product:
GABA-ergics & GABA Receptors / Related Products
 
 
ALX-630-002 Revised 20-Nov-07
Tetrodotoxin (citrate free)
Add to Clipboard
SYNONYMS Fugu poison
TTX
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-002-M001   1 mg Inquire
Product Specification
FORMULA: C11H17N3O8
MW: 319.3
CAS NUMBER: 4368-28-9
MERCK INDEX: 14: 9246
RTECS: IO1450000
SOURCE/HOST: Isolated from ovaries and liver of chinese puffer fish.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute acetic acid or citrate buffer (pH 4.8–4.9). Do not use alkaline solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Do not use in alkaline media.
HAZARD: VERY TOXIC.

Product Description
Potent neurotoxin. Blocks voltage-gated fast Na+ channels in nerve cell membranes.
Product Specific Literature References
The constituents of the ovaries of globefish. VIII. Studies on tetrodotoxin: K. Tsuda & M. Kawamura; Pharm. Bull. 1, 112 (1953) Abstract
Recent advances in the study of mechanism of action of marine neurotoxins: T. Narahashi, et al.; Neurotoxicology 15, 545 (1994), (Review) Abstract
Tetrodotoxin poisoning: D.F. Hwang & T. Noguchi; Adv. Food Nutr. Res. 52, 141 (2007), (Review) Abstract
Further Categories Containing This Product:
Na+ Channels • Marine Natural Products
 
 
ALX-630-047 Revised 14-Oct-08
μ-Conotoxin GS
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-047-C500   500 µg 790.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Cys-Ser-Gly-Arg-Gly-Ser-Arg-Cys-Hyp-Hyp-Gln-Cys-Cys-Met-Gly-Leu-Arg-Cys-Gly-Arg-Gly-Asn-Pro-Gln-Lys-Cys-Ile-Gly-Ala-His-Gla-Asp-Val-OH
(Disulfide bonds between Cys2-Cys14, Cys9-Cys19and Cys13-Cys27) (Gla = L-γ-Carboxyglutamic acid)
FORMULA: C139H220N52O48S7
MW: 3612.1
SOURCE/HOST: Synthetic. Originally isolated from Conus geographus.
QUANTITY: 0.55mg (0.15µmol)
CONCENTRATION: 0.1mM after reconstitution.
PURITY: ≥97%
APPEARANCE: Lyophilized.
RECONSTITUTION: Do not remove the cap. Inject 1.5ml of water or 0.9% sodium chloride into the vial using a syring. Let the contents dissolve thoroughly.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY:

Stable for at least 1 year when stored at -20°C. Stock solutions are stable for a few weeks at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. Na+ channel blocker. Not for sale in U.S.A.
Product Specific Literature References
A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties: Y. Yanagawa, et al.; Biochemistry 27, 6256 (1988) Abstract
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry: J.M. Hill, et al.; Structure 5, 571 (1997) Abstract
Using the deadly mu-conotoxins as probes of voltage-gated sodium channels: R. A. Li & G. F. Tomaselli; Toxicon 44, 117 (2004), (Review) Abstract
Further Categories Containing This Product:
Peptides • Na+ Channels • Marine Natural Products
 
 
ALX-630-054 Revised 14-Oct-08
μ-Conotoxin GIIIB
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-054-C500   500 µg 790.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2
(Disulfide bonds between Cys3-Cys15, Cys4-Cys20and Cys10-Cys21)
FORMULA: C101H175N39O30S7
MW: 2640.2
SOURCE/HOST: Synthetic. Originally isolated from Conus geographus.
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. Specific blocker of the skeletal voltage-gated Na+ channels. Not for sale in U.S.A.
Product Specific Literature References
Conus geographus toxins that discriminate between neuronal and muscle sodium channels: L.J. Cruz, et al.; J. Biol. Chem. 260, 9280 (1985) Abstract; Full Text
Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse: S.J. Hong & C.C. Chang; Br. J. Pharmacol. 97, 934 (1989) Abstract
Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle: M. Kimura, et al.; J. Pharmacol. Exp. Ther. 256, 18 (1991) Abstract
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels: R. Robitaille & M.P. Charlton; J. Neurosci. 12, 297 (1992) Abstract
Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction: S. Kubo, et al.; Pept. Res. 6, 66 (1993) Abstract
Using the deadly mu-conotoxins as probes of voltage-gated sodium channels: R. A. Li & G. F. Tomaselli; Toxicon 44, 117 (2004), (Review) Abstract
Further Categories Containing This Product:
Peptides • Na+ Channels • Marine Natural Products
 
 
© 2008 ALEXIS Corporation, Privacy Policy, Disclaimer, Feedbackheader picture © micronaut.ch, another CS2 website

Catalogs / Brochures

E-Newsletter

 

Shopping Cart [0]

 

Distributors

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.