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ALX-210-200
Revised 22-Feb-05
Polyclonal Antibody to Prion Protein (sheep)
SYNONYMS
anti-PrP (sheep) PAb
anti-CD230 (sheep) PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Prion Protein / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-200-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Sheep
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 90-102 (G
90
QGGGTHNQWNKP
102
) of hamster PrP (prion protein).
SPECIFICITY:
Recognizes sheep PrPC 33-35 and PrPSc 27-30.
APPLICATION:
Immunohistochemistry (formalin-fixed sections (1:20))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-035
.
Product Specific Literature References
Characterization of prion proteins with monospecific antisera to synthetic peptides:
R.A. Barry, et al.; J. Immunol.
140
, 1188 (1988)
Abstract
Related Products
ALX-165-035
Blocking Peptide for PAb to Prion Protein (sheep) (Prod. No.
ALX-210-200
)
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-230
Revised 10-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor
SYNONYMS
anti-NGFR PAb
anti-TNFRSF 16 PAb
anti-p75
NTR
PAb
anti-p75 Neurotrophin Receptor PAb
anti-CD271 PAb
anti-Low-affinity Nerve Growth Factor Receptor PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-230-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to a portion of C-terminal human NGFR (nerve growth factor receptor; p75
NTR
).
SPECIFICITY:
Recognizes human, rat and chicken NGFR.
APPLICATION:
Immunoprecipitation (2µl/sample)
Western Blot (1:250-1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-234
Revised 29-Apr-08
Polyclonal Antibody to CD44var(v3-v10) (human)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
CD44 / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-234-M001
1 mg
308.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4.
IMMUNOGEN:
Recombinant human CD44var(v3-v10).
SPECIFICITY:
Recognizes epitopes encoded by exons v3-v10 of human variant CD44.
APPLICATION:
Immunohistochemistry
: Recommended is the alkaline phosphatase-anti-alkaline-phosphatase (APAAP) or peroxidase anti-peroxidase (PAP) procedure or the three stage immunoperoxidase technique on acetone fixed frozen sections (50µg/ml). Use of biotinylated swine anti-goat, mouse, rabbit immunoglobulins is recommended. Blocking should be done with swine serum.
Paraffin-embedded tissue after microwave treatment (1x5 min.) (20µg/ml).
Western Blot
(1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-367
Revised 25-Sep-08
Polyclonal Antibody to Toll-like Receptor 3 (mouse)
SYNONYMS
anti-TLR3 (mouse) PAb
anti-CD283 (mouse) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-367-R200
200 µl
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptides corresponding to aa 135-150, 828-844 and 876-891 of mouse TLR3 (Toll-like receptor 3).
SPECIFICITY:
Recognizes mouse TLR3. Does not cross-react with human TLR3.
APPLICATION:
Flow Cytometry (cell surface & intracellular (1μg/10
6
cells) (see [2]))
Immunohistochemistry (paraffin sections (1:50), frozen sections (see [1]))
Western Blot (1-3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells:
P.S. Patole, et al.; J. Am. Soc. Nephrol.
16
, 1326 (2005)
Abstract
[2]
Toll-like receptor-7 modulates immune complex glomerulonephritis:
R.D. Pawar, et al.; J. Am. Soc. Nephrol.
17
, 141 (2006)
Abstract
[3]
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice:
P.S. Patole, et al.; Nephrol. Dial. Transplant.
21
, 3062 (2006)
Abstract
Further Categories Containing This Product:
Antiviral Signalling / Related Products
•
Polyclonal Antibodies
•
CD Antibodies
ALX-210-368
Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 9
SYNONYMS
anti-TLR9 PAb
anti-CD289 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-368-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 275-291 of mouse TLR9 (Toll-like receptor 9) (extracellular domain).
SPECIFICITY:
Recognizes human and mouse TLR9. Detects a band of ~113kDa by Western blot.
APPLICATION:
Flow Cytometry (intracellular (1-2µg/10
6
))
Flow Cytometry (cell surface (see [6]))
Immunocytochemistry (see [5])
Immunocytochemistry (paraffin sections (see [8]); frozen sections (10µg/ml) (see [6]))
Western Blot (0.5-1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Toll-like receptor 9 regulates tumor necrosis factor-alpha expression by different mechanisms. Implications for osteoclastogenesis:
A. Amcheslavsky, et al.; J. Biol. Chem.
279
, 54039 (2004)
Abstract
;
Full Text
[2]
IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA:
M. Uchijima, et al.; Immunol. Cell Biol.
83
, 92 (2005)
Abstract
[3]
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects:
I.N. Buhtoiarov, et al.; J. Immunol.
176
, 309 (2006)
Abstract
;
Full Text
[4]
Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide:
L. Chen, et al.; J. Immunol.
177
, 2373 (2006)
Abstract
;
Full Text
[5]
Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity:
M.A. Merrell, et al.; Mol. Cancer Res.
4
, 437 (2006)
Abstract
;
Full Text
[6]
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice:
P.S. Patole, et al.; Nephrol. Dial. Transplant.
21
, 3062 (2006)
Abstract
[7]
Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro:
J.M. Ilvesaro, et al.; Prostate
67
, 774 (2007)
Abstract
[8]
Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation:
N. Tran, et al.; ; J. Clin. Endocrinol. Metab.
92
, 2773 (2007)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-369
Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 2
SYNONYMS
anti-TLR2 PAb
anti-Toll/Interleukin-1 Receptor-like Gene 4 PAb
anti-TIL4 PAb
anti-CD282 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-369-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN:
Extracellular domain of mouse TLR2 (Toll-like receptor 2) (aa 564-580).
SPECIFICITY:
Recognizes human and mouse TLR2. Detects a band of ~86kDa by Western blot.
APPLICATION:
Western Blot (0.5-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages:
S.K. Pathak, et al.; J. Biol. Chem.
279
, 55127 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-396
Revised 27-Mar-08
Polyclonal Antibody to RANKL (human)
SYNONYMS
anti-ODF (human) PAb
anti-OPGL (human) PAb
anti-TRANCE (human) PAb
anti-TNFSF 11 (human) PAb
anti-CD254 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
RANK & RANKL
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
Add To Cart
ALX-210-396-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human RANKL.
SPECIFICITY:
Recognizes human RANKL. Detects a band of ~35kDa band by Western blot.
APPLICATION:
ELISA
(direct and indirect: 1:2'000-1:10'000).
Flow Cytometry
(1:500-1:1'000).
Western Blot
(1:2'000-1:5'000 using ECL).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-414
Revised 03-Oct-05
Polyclonal Antibody to CD137 (human)
SYNONYMS
anti-4-1BB (human) PAb
anti-TNFRSF 9 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CD137 & CD137L / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-414-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Human CD137.
SPECIFICITY:
Recognizes human CD137. Detects a band of ~29kDa by Western blot. Does not cross-react with mouse CD137.
APPLICATION:
Flow Cytometry (1:500-1:1'000)
Western Blot (1:2'000-1:5'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-421
Revised 30-Oct-06
Polyclonal Antibody to RANK (ectodomain) (human)
SYNONYMS
anti-TRANCE-R (ectodomain) (human) PAb
anti-ODFR (ectodomain) (human) PAb
anti-TNFRSF 11A (ectodomain) (human) PAb
anti-CD265 (ectodomain) (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
RANK & RANKL
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-421-C050
50 µg
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Contains no preservatives.
IMMUNOGEN:
Recombinant human RANK.
SPECIFICITY:
Recognizes human RANK. Detects a band of ~24kDa by Western blot.
APPLICATION:
Flow Cytometry
Western blot
(1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-537
Revised 10-Apr-08
Polyclonal Antibody to CD51
SYNONYMS
anti-αV Integrin PAb
Polyclonal Antibody to Vitronectin Receptor (α Subunit)
anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-537-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY:
Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION:
ELISA
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
Immunoprecipitation (5µl per 5x10
6
cells)
Western Blot (1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development:
E. Hirsch, et al.; Dev. Dyn.
201
, 108 (1994)
Abstract
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products
•
Integrins / Related Products
•
Polyclonal Antibodies
•
Bone Metabolism Other Products
ALX-210-618
Revised 28-Aug-08
Polyclonal Antibody to N-cadherin
SYNONYMS
anti-CD325 PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cadherin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-618-C400
400 µg
320.00 USD
