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Prostaglandins Other Products
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ALX-270-480 Revised 10-Mar-08
Caffeic acid ethyl ester
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SYNONYMS CAEE
Ethyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-480-M050   50 mg 20.00 USD Add To Cart
ALX-270-480-M250   250 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C11H12O4
MW: 208.2
CAS NUMBER: 66648-50-8
SOURCE/HOST: Synthetic.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at -20°C.
HANDLING: Protect from light and moisture.

Product Description
Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC50=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H2O2.
Product Specific Literature References
Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells: T. Nakayama, et al.; Biosci. Biotechnol. Biochem. 60, 316 (1996) Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin: Y.M. Chiang, et al.; Br. J. Pharmacol. 146, 352 (2005) Abstract
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines: M. Cardenas, et al.; Bioorg. Med. Chem. 14, 2966 (2006) Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006) Abstract
Related Products
Further Categories Containing This Product:
Prostaglandins Other Products • Natural Products - Chemopreventive Agents • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Immunomodulators • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids • NF-kB Pathway Inhibitors
 
 
ALX-430-112 Revised 20-Aug-03
Phenylbutazone
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SYNONYMS 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-112-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C19H20N2O2
MW: 308.4
CAS NUMBER: 50-33-9
MERCK INDEX: 14: 7277

Product Description
Anti-inflammatory agent. Substrate for prostaglandin peroxidase.
Further Categories Containing This Product:
Prostaglandins Other Products
 
 
ALX-550-300 Revised 27-Nov-08
TMB-8 . hydrochloride
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SYNONYMS 8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate . HCl
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-550-300-M025   25 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C22H37NO5 . HCl
MW: 395.5 . 36.5
CAS NUMBER: 53464-72-5
PURITY: ≥98% (TLC)
APPEARANCE: White solid.
SOLUBILITY: Soluble in water (20 mg/ml cloudy) or 100% ethanol (25 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.

Product Description
Intracellular Ca2+ antagonist of serum-stimulated Na+ influx in human fibroblasts. Inhibits platelet-activating factor (PAF) and PMA-stimulated prostaglandin production in Kupffer cells.
Product Specific Literature References
Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl- 3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist: M. Sawamura; J. Med. Sci. 31, 221 (1985) Abstract
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells: C.R. Gandhi, et al.; Biochim. Biophys. Acta 1136, 68 (1992) Abstract
Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake: F.B. Palmer, et al.; Biochem. J. 286, 505 (1992) Abstract
Further Categories Containing This Product:
Ca2+ Modulators • Acetylcholine Receptors (Muscarinic) / Related Products • Prostaglandins Other Products • Acetylcholine Receptors Other Products • Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-270-360 Revised 21-May-08
Tryptanthrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
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ALX-270-360-M001   1 mg 50.00 USD Add To Cart
ALX-270-360-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H8N2O2
MW: 248.2
CAS NUMBER: 13220-57-0
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Yellow needles.
SOLUBILITY: Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING: Protect from light and moisture.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, MS and UV.

Product Description
Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. ALX-380-042) resistance on breast cancer cells.
Product Specific Literature References
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001) Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002) Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000) Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003) Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007) Abstract
General Information
Tryptanthrin occurs as a natural product in various plants, including Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria and Calanthe discolor.
Further Categories Containing This Product:
Leukotrienes Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • MDR Inhibitors • Prostaglandins Other Products • P-glycoprotein [Pgp] / Related Products • Natural Products - Nitric Oxide Pathway Modulators • COX Inhibitors
 
 
ALX-340-014 Revised 08-Jul-08
U-44069
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SYNONYMS 9,11-Dideoxy-9α,11α-epoxymethano prostaglandin F2α
PRODUCT LINE Inflammation
PRODUCT CATEGORY Prostaglandins Other Products
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ALX-340-014-M001   1 mg 123.00 USD Add To Cart
ALX-340-014-M005   5 mg 551.00 USD Add To Cart
Product Specification
FORMULA: C21H34O4
MW: 350.5
CAS NUMBER: 56985-32-1
CONCENTRATION: 10mg/ml
PURITY: ≥98%
APPEARANCE: Liquid. Solution in methyl acetate.
SOLUBILITY: 100mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in aqueous 0.01M Na2CO3 (6mg/ml) or PBS, pH 7.2 (2mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Prostaglandin endoperoxide receptor agonist/antagonist.
Product Specific Literature References
Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium: W.K. Pollock, et al.; Biochem. J. 219, 833 (1984) Abstract
Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i: A.W.M. Simpson, et al.; FEBS Lett. 201, 301 (1986) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
 
 
ALX-340-015 Revised 08-Jul-08
U-46619
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SYNONYMS 9,11-Dideoxy-9α,11α-methanoepoxy prostaglandin F2α
PRODUCT LINE Inflammation
PRODUCT CATEGORY Thromboxanes / Related Products
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ALX-340-015-M001   1 mg 94.00 USD Add To Cart
ALX-340-015-M005   5 mg 422.00 USD Add To Cart
Product Specification
FORMULA: C21H34O4
MW: 350.5
CAS NUMBER: 56985-40-1
CONCENTRATION: 10mg/ml
PURITY: ≥98%
FORMULATION: Liquid. Solution in methyl acetate.
SOLUBILITY: 100mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 2mg/ml soluble in PBS, pH 7.2.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Prostaglandin H2/thromboxane A2 receptor agonist; stable analog of thromboxane A2.
Product Specific Literature References
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations: R.A. Coleman, et al.; Br. J. Pharmacol. 73, 773 (1981) Abstract
Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues: S.E. Burke, et al.; Br. J. Pharmacol. 78, 287 (1983) Abstract
Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets: N. Liel, et al.; Prostaglandins 33, 789 (1987) Abstract
Heterogeneity of thromboxane A2 (TP-) receptors: evidence from antagonist but not agonist potency measurements: P.M. Tymkewycz, et al.; Br. J. Pharmacol. 102, 607 (1991) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Prostaglandins Other Products
 
 
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