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Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-350-312 Revised 28-May-08
(-)-Arctigenin
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SYNONYMS (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-312-M025   25 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H24O6
MW: 372.4
CAS NUMBER: 7770-78-7
SOURCE/HOST: Isolated from Arctium lappa.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (34mg/ml, heating, sonication); sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca2+. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
Product Specific Literature References
Antiproliferative effect of Arctigenin and Arctiin: S.Y. Ryu, et al.; Arch. Pharm. Res. 18, 462 (1995)
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase: E. Eich, et al.; J. Med. Chem 39, 86 (1996) Abstract
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation: J.Y. Cho, et al.; J. Pharm. Pharmacol. 51, 1267 (1999) Abstract
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor: Y.P. Jang, et al.; J. Neurosci. Res. 68, 233 (2002) 68, 233 (2002) Abstract
A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris: A. Koulman, et al.; Planta Med. 69, 733 (2003) Abstract
Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells: B. Hausott, et al.; J. Cancer Res. Clin. Oncol. 129, 569 (2003) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation: S. Awale, et al.; Cancer Res. 66, 1751 (2006) Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme: K. Kang, et al.; Biol. Pharm. Bull. 30, 2352 (2007) Abstract
 
 
ALX-350-318 Revised 17-Jun-08
(-)-Arctiin
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SYNONYMS (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-318-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C27H34O11
MW: 534.6
CAS NUMBER: 20362-31-6
SOURCE/HOST: Isolated from Arctium lappa.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml); sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description

Lignan derivative with antitumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor and Ca2+.

Product Specific Literature References
Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes: S. Iwakami, et al.; Chem. Pharm. Bull. (Tokyo) 40, 1196 (1992) Abstract
Antiproliferative effect of Arctigenin and Arctiin: S.Y. Ryu, et al.; Arch. Pharm. Res. 18, 462 (1995)
Cytotoxic components of bardanae fructus (goboshi): S. Moritani, et al.; Biol. Pharm. Bull. 19, 1515 (1996) Abstract
Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection: A.J. Vlietinck, et al.; Planta Med. 64, 97 (1998) Abstract
Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa: M. Takasaki, et al.; Cancer Lett. 158, 53 (2000) Abstract
Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS: S. Liu, et al.; Phytochem. Anal. 16, 86 (2005) Abstract
Application of preparative high-speed counter-current chromatography for separation and purification of arctiin from Fructus Arctii: X. Wang, et al.; J. Chromatogr. A. 1063, 247 (2005) Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme: K. Kang, et al.; Biol. Pharm. Bull. 30, 2352 (2007) Abstract
 
 
ALX-301-013 Revised 08-Jul-08
Azelaoyl-PAF
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SYNONYMS 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-013-M001   1 mg 58.00 USD Add To Cart
ALX-301-013-M005   5 mg 261.00 USD Add To Cart
Product Specification
FORMULA: C33H66NO9P
MW: 651.9
SOURCE/HOST: Synthetic.
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO (8mg/ml) or dimethyl formamide (33mg/ml) or PBS, pH 7.2 (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Potent PPARγ agonist which competes for the thiazoladinedione binding site. More potent than 15-deoxy-Δ12,14-prostaglandin J2 (Prod. No. ALX-340-022) and equipotent with rosiglitazone (Prod. No. ALX-350-125) as a ligand for this receptor.
Product Specific Literature References
Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists: S.S. Davies, et al.; J. Biol. Chem. 276, 16015 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Phospholipids / Related ProductsPPAR Agonists
 
 
ALX-350-100 Revised 03-Apr-08
Convulxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-100-C050   50 µg 565.00 USD Add To Cart
Product Specification
MW: ~84kDa.
CAS NUMBER: 37206-04-5
SOURCE/HOST: Isolated from Crotalus durissus terrificus snake venom.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in organic buffer (HEPES).
ACTIVITY: <50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
APPLICATION: Studies on platelet receptors.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
HAZARD: TOXIC.
Product Description
Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions.
Product Specific Literature References
Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981) Abstract
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997) Abstract
Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998) Abstract
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000) Abstract
Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003) Abstract
Structure of the snake-venom toxin convulxin: T. Batuwangala, et al.; Acta Crystallogr. D. Biol. Crystallogr. 60, 46 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Assay performed in aggregometer:
- Incubate 485µl platelets suspension (5x108 platelets/ml) for 1-2 minutes at 37°C until base line is stable.
- Add 5µl 200mM CaCl2.
- Add 5µl 200mM MgCl2.
- Wait until baseline is stable.
- Add 5µl collagen solution (0.5mg/ml) for positive control OR add 5µl convulxin (0.1µg/ml in HEPES).
- Measure aggregation at 37°C.
 
 
ALX-301-009 Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-009-M005   5 mg 45.00 USD Add To Cart
ALX-301-009-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C30H62NO7P
MW: 579.8
CAS NUMBER: 99103-16-9
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in chloroform, 100% ethanol or methanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Product Description
PAF antagonist. Shows inhibitory behavior on platelet aggregation, secretion and phospholipid turnover.
Product Specific Literature References
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation: A. Tokumura, et al.; J. Biol. Chem. 260, 12710 (1985) Abstract; Full Text
Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages: M. Rouis, et al.; BBRC 156, 1293 (1988) Abstract
 
 
ALX-301-002 Revised 09-Dec-04
Lyso-PAF (C16)
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SYNONYMS 1-O-Hexadecyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-002-M001   1 mg 15.00 USD Add To Cart
ALX-301-002-M005   5 mg 45.00 USD Add To Cart
ALX-301-002-M025   25 mg 135.00 USD Add To Cart
ALX-301-002-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C24H52NO6P
MW: 481.7
CAS NUMBER: 52691-62-0
SOURCE/HOST: Synthetic.
PURITY: ≥98%
SOLUBILITY: Soluble in chloroform, methanol or ethanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-004 Revised 09-Dec-04
Lyso-PAF (C18)
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SYNONYMS 1-O-Octadecyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-004-M001   1 mg 15.00 USD Add To Cart
ALX-301-004-M005   5 mg 45.00 USD Add To Cart
ALX-301-004-M025   25 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C26H56NO6P
MW: 509.7
CAS NUMBER: 74430-89-0
SOURCE/HOST: Sythetic.
PURITY: ≥98%
SOLUBILITY: Soluble in chloroform, methanol or 100% ethanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-804-033 Revised 04-Nov-08
Monoclonal Antibody to PAF Receptor (11A4 (clone 21))
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SYNONYMS anti-Platelet Activating Factor Receptor MAb (11A4 (clone 21))
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-804-033-C100   100 µg 269.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Pig
Others
CLONE: 11A4 (clone 21)
ISOTYPE: Mouse IgG2a
CONCENTRATION: 0.2mg/ml 
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In TBS, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 260-269 (L260GFQDSKFHQ269) of human PAF receptor (platelet activating factor receptor).
SPECIFICITY: Recognizes human, bovine and pig PAF receptor.
APPLICATION: Immunocytochemistry (2.5 μg/ml)
For flow cytometry and Western blot, we recommend PAb to PAF Receptor (Prod. No. ALX-210-715).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
BLOCKING PEPTIDE: yes
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-850-202 Revised 24-Feb-05
PAF Acetylhydrolase Assay Kit
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-850-202-KI01   1 Kit 349.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.02-0.2µmol/min/ml
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the measurement of platelet-activating factor acetylhydrolase (PAF-AH) activity (both cytosolic and extracellular).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Images
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Product Specific Literature References
Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase and platelet-activating-factor acetylhydrolase: A.J. Aarsman, et al.; Eur. J. Biochem. 200, 187 (1991) Abstract
Further Categories Containing This Product:
Activity Assays
 
 
ALX-301-001 Revised 09-Dec-04
PAF (C16)
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SYNONYMS 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-001-M001   1 mg 15.00 USD Add To Cart
ALX-301-001-M005   5 mg 40.00 USD Add To Cart
ALX-301-001-M025   25 mg 145.00 USD Add To Cart
ALX-301-001-M100   100 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C26H54NO7P
MW: 523.7
CAS NUMBER: 74389-68-7
MERCK INDEX: 14: 7524
SOURCE/HOST: Synthetic.
PURITY: ≥99%
SOLUBILITY: Soluble in chloroform, methanol or 100% ethanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-301-010 Revised 18-Feb-08