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CXC Chemokines & Receptors / Related Products
You are here: Product Lines > Chemokines & Cytokines > Chemokines & Chemokine Receptors / Related Products > CXC Chemokines & Receptors / Related Products
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ALX-210-819 Revised 06-Nov-08
Polyclonal Antibody to CXCR4 (mouse)
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SYNONYMS anti-CXC Chemokine Receptor 4 (mouse) PAb
anti-CD184 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-819-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 1 mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-40 (Y14SEEVGSGDYDS
NKEPCFRDENVHFNR40) of the N-terminal extracellular domain of mouse CXCR4 (CXC chemokine receptor 4).
SPECIFICITY: Recognizes mouse CXCR4.
APPLICATION: Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:200))
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-034.
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-820 Revised 25-Jan-07
Polyclonal Antibody to CXCR4 (human)
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SYNONYMS anti-CXC Chemokine Receptor 4 (human) PAb
anti-CD184 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-820-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 13-38 (CT13EEMGSGDYDSMKEPCFREENANFNK38) of the N-terminal extracellular domain of human CXCR4 (CXC chemokine receptor 4).
SPECIFICITY: Recognizes human CXCR4.
APPLICATION: Immunocytochemistry (acetone fixed cells (1:300))
Immunohistochemistry (paraffin sections (1:200))
Western Blot (1:1’000)
Functional Application (blocks SDF mediated stimulation of DU-145 cells)
QUALITY CONTROL: Immunocytochemistry on human peripheral blood cells and immunohistochemistry on paraffin sections of human spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-035.
General Literature References
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes: M. Loetscher, et al.; J. Biol. Chem. 269, 232 (1994) Abstract
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry: C.C. Bleul, et al.; Nature 382, 829 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-270-478 Revised 30-Jul-08
SB 225002
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SYNONYMS N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-478-M001   1 mg 30.00 USD Add To Cart
ALX-270-478-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C13H10BrN3O4
MW: 352.1
CAS NUMBER: 182498-32-4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR and 13C-NMR.

Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998) Abstract; Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003) Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006) Abstract; Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
 
 
ALX-804-039 Revised 02-Mar-06
Monoclonal Antibody to IL-8 Receptor, Type A (human) (SE 2)
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SYNONYMS anti-Interleukin-8 Receptor, Type A (human) MAb (SE 2)
Monoclonal Antibody to CXCR1 (human) (SE 2)
anti-CXCR1 (human) MAb (SE 2)
anti-CXC Chemokine Receptor 1 (human) MAb (SE 2)
anti-CD181 (human) MAb (SE 2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-039-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: SE 2
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in TRIS/glycine containing 0.05% sodium azide.
IMMUNOGEN: Human IL-8 (interleukin-8) receptor, type A.
SPECIFICITY: Recognizes purified human IL-8 receptor, type A.
APPLICATION: Flow Cytometry (10µg/ml)
Immunohistochemistry (acetone fixed frozen sections)
Western Blot
Note: NOT suitable for neutralizing assay.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2: A. Ludwig, et al.; Blood 90, 4588 (1997) Abstract; Full Text
Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid: S. Zahn, et al.; Eur. J. Immunol. 27, 935 (1997) Abstract
The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils: H. Petering, et al.; Blood 93, 694 (1999) Abstract; Full Text
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-040 Revised 02-Mar-06
Monoclonal Antibody to IL-8 Receptor, Type B (human) (HC 2)
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SYNONYMS anti-Interleukin-8 Receptor, Type B (human) MAb (HC 2)
anti-CXCR2 (human) MAb (HC 2)
anti-CXC Chemokine Receptor 2 (human) MAb (HC 2)
anti-CD182 (human) MAb (HC 2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-040-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HC 2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in TRIS/HCl containing 0.05% sodium azide.
IMMUNOGEN: Human IL-8 (interleukin-8) receptor, type B.
SPECIFICITY: Recognizes human IL-8 receptor, type B.
APPLICATION: Flow Cytometry
Immunohistochemistry (acetone fixed frozen sections)
Western Blot
Note: NOT suitable for neutralizing assay.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid: S. Zahn, et al.; Eur. J. Immunol. 27, 935 (1997) Abstract
The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils: H. Petering, et al.; Blood 93, 694 (1999) Abstract; Full Text
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-592 Revised 31-Jul-07
Monoclonal Antibody to IL-8 Receptor, Type A (human) (X1.53)
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SYNONYMS anti-Interleukin-8 Receptor, Type A (human) MAb (X1.53)
Monoclonal Antibody to CXCR1 (human) (X1.53)
anti-CXCR1 (human) MAb (X1.53)
anti-CXC Chemokine Receptor 1 (human) MAb (X1.53)
anti-CD181 (human) MAb (X1.53)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptor Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-592-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: X1.53
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: L1.2 cells expressing human IL-8 (interleukin-8) receptor, type A.
SPECIFICITY: Recognizes human IL-8 receptor, type A.
APPLICATION: Flow Cytometry (5µg/ml)
Immunohistochemistry (frozen sections)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-593 Revised 31-Jul-07
Monoclonal Antibody to IL-8 Receptor, Type B (human) (X2.7)
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SYNONYMS anti-Interleukin-8 Receptor, Type B (human) MAb (X2.7)
anti-CXCR2 (human) MAb (X2.7)
anti-CXC Chemokine Receptor 2 (human) MAb (X2.7)
anti-CD182 (human) MAb (X2.7)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-593-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: X2.7
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: L1.2 cells expressing human IL-8 (interleukin-8) receptor, type B.
SPECIFICITY: Recognizes human IL-8 receptor, type B.
APPLICATION: Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
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