ALEXIS Biochemicals: Withaferin A

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ALX-350-345

Revised 21-May-08

trans-3,4’,5-Trimethoxy-stilbene
SYNONYMS	Trimethoxy-resveratrol MR-3
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Angiogenesis Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-345-M025		25 mg	20.00 USD
ALX-350-345-M100		100 mg	60.00 USD

Product Specification

FORMULA:	C₁₇H₁₈O₃
MW:	270.3
CAS NUMBER:	22255-22-7
PURITY:	≥97% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Analog of resveratrol (Prod. No. ALX-270-125). Shows powerful anti-angiogenic activity.

Product Specific Literature References

Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene: M. Belleri, et al.; Mol. Pharmacol. 67, 1451 (2005) Abstract; Full Text
Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells: H. Matsuda, et al.; Bioorg. Med. Chem. 12, 4871 (2004) Abstract
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators: P. de Medina, et al.; J. Med. Chem. 48, 287 (2005) Abstract
Antitumor activity of 3,5,4’-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice: M.H. Pan, et al.; Mol. Carcinog. 47, 184 (2008) Abstract

Related Products

ALX-270-125

Resveratrol

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Stilbenoids

ALX-350-153

Revised 28-Jul-08

Withaferin A
SYNONYMS	5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-153-M001		1 mg	60.00 USD
ALX-350-153-M005		5 mg	240.00 USD

Product Specification

FORMULA:	C₂₈H₃₈O₆
MW:	470.6
CAS NUMBER:	5119-48-2
MERCK INDEX:	14: 10048
RTECS:	KE7288500
SOURCE/HOST:	Isolated from Withania somnifera.
PURITY:	≥94% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (20 mg/ml), methanol (10 mg/ml) or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	MAY BE MUTAGENIC. MAY BE CARCINOGENIC. HARMFUL.

Product Description

Cell permeable and potent angiogenesis inhibitor from the family of withanolides. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC₅₀=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits NF-κB activation by preventing the TNF-induced activation of IκB kinase β (IKKβ). Affects AP1 transcription and induces cell death. Alters cytoskeletal architecture by covalently binding annexin II and stimulating its basal F-actin cross-linking activity which inhibits the migratory and invasive capability of endothelial cells. Displays neuronal regenerative properties. Targets the intermediate filament protein vimentin.

Product Specific Literature References

Tumor inhibitors. XXXIX. Active principles of Acnistus arborescens. Isolation and structural and spectral studies of withaferin A and withacnistin: S.M. Kupchan, et al.; J. Org. Chem. 34, 3858 (1969) Abstract
In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma: P.U. Devi, et al.; Cancer Lett. 95, 189 (1995) Abstract
Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves: B. Jayaprakasam, et al.; Life Sci. 74, 125 (2003) Abstract
Withaferin A is a potent inhibitor of angiogenesis: R. Mohan, et al.; Angiogenesis 7, 115 (2004) Abstract
Neuritic regeneration and synaptic reconstruction induced by withanolide: A: T. Kuboyama, et al.; Br. J. Pharmacol. 144, 961 (2005) Abstract; Full Text
Actin microfilament aggregation induced by withaferin A is mediated by annexin II: R.R. Falsey, et al.; Nat. Chem. Biol. 2, 33 (2006) Abstract
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity: M. Kaileh, et al.; J. Biol. Chem. 282, 4253 (2007) Abstract; Full Text
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin: P. Bargagna-Mohan, et al.; Chem. Biol. 14, 623 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Immunomodulators • Natural Products for Angiogenesis Research • Natural Products - NF-kB Pathway Inhibitors • Natural Products for Cytoskeletal Research • Vimentin / Related Products • Natural Products - Anti-inflammatory Agents • NF-kB Pathway Inhibitors • Antitumor Agents (Apoptosis Inducers)

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