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ALX-430-096
Revised 24-Feb-05
A77 1726
SYNONYMS
N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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Product Numbers:
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ALX-430-096-M005
5 mg
45.00 USD
ALX-430-096-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
12
H
9
F
3
N
2
O
2
MW:
270.2
CAS NUMBER:
108605-62-5
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No.
ALX-430-095
). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2)
in vitro
and
in vivo
.
Product Specific Literature References
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide:
T. Mattar, et al.; FEBS Lett.
334
, 161 (1993)
Abstract
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide:
X. Xu, et al.; J. Biol. Chem.
270
, 12398 (1995)
Abstract
;
Full Text
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase:
J.P. Davis, et al.; Biochemistry
35
, 1270 (1996)
Abstract
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation:
X. Xu, et al.; Biochem. Pharmacol.
52
, 527 (1996)
Abstract
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms:
R.T. Elder, et al.; J. Immunol.
159
, 22 (1997)
Abstract
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice:
X. Xu, et al.; J. Immunol.
159
, 167 (1997)
Abstract
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression:
S.K. Manna & B.B. Aggarwal; J. Immunol.
162
, 2095 (1999)
Abstract
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner:
L.C. Hamilton, et al.; Br. J. Pharmacol.
127
, 1589 (1999)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
COX Inhibitors
•
Immunomodulators Other Products
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
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ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
Natural Products - Protein Kinase Inhibitors
•
Lipoxygenases / Related Products
•
NF-kB Pathway Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
ALX-430-110
Revised 16-Jan-08
5-Aminosalicylic acid
SYNONYMS
5-ASA
Mesalamine
5-Amino-2-hydroxybenzoic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
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ALX-430-110-G005
5 g
20.00 USD
Product Specification
FORMULA:
C
7
H
7
NO
3
MW:
153.1
CAS NUMBER:
89-57-6
MERCK INDEX:
14:
5904
PURITY:
≥98%
SOLUBILITY:
Soluble in 1 M hydrochloric acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibits TNF-α regulated IκB degradation and NF-κB activation.
Product Specific Literature References
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine
:
S. Liptay, et al.; Br. J. Pharmacol.
128
, 1361 (1999)
Abstract
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells
:
F. Yan & D.B. Polk; J. Biol. Chem.
274
, 36631 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
ALX-340-029
Revised 08-Jul-08
Anandamide
SYNONYMS
AEA
N-Arachidonoylethanolamine
(all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
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ALX-340-029-M005
5 mg
51.00 USD
Product Specification
FORMULA:
C
22
H
37
NO
2
MW:
347.5
CAS NUMBER:
94421-68-8
MERCK INDEX:
14:
624
RTECS:
JX3842500
CONCENTRATION:
50mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
10mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C.
HANDLING:
Protect from light and oxygen.
Product Description
Endogenous [1] ligand for the CB
1
receptor (CB
1
: K
i
=52nm; CB
2
: K
i
=1930nm [2]) and TRPV1 (K
i
=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].
Product Specific Literature References
[1]
Isolation and structure of a brain constituent that binds to the cannabinoid receptor:
W.A. Devane, et al.; Science
258
, 1946 (1992)
Abstract
[2]
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
:
S. Lin, et al.; J. Med. Chem.
41
, 5353 (1998)
Abstract
[3]
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
:
P.M. Zygmunt, et al.; Nature
400
, 452 (1999)
Abstract
[4]
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
:
R.A. Ross, et al.; Br. J. Pharmacol.
132
, 631 (2001)
Abstract
[5]
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway
:
R. Sancho, et al.; Mol. Pharmacol.
63
, 429 (2003)
Abstract
[6]
Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts
:
K.P. Sarker, et al.; Cell Mol. Life Sci.
60
, 1200 (2003)
Abstract
[7]
The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide
:
M. Wartmann, et al.; FEBS Lett.
359
, 133 (1995)
Abstract
Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid:
C.J. Hillard & W.B. Campbell; J. Lipid Res.
38
, 2383 (1997), (Review)
Abstract
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
:
L. De Petrocellis, et al.; PNAS
95
, 8375 (1998)
Abstract
Cannabinoid receptors and their endogenous agonist, anandamide:
J. Axelrod & C.C. Felder; Neurochem. Res.
23
, 575 (1998), (Review)
Abstract
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action:
V. Di Marzo, et al.; TINS
21
, 521 (1998), (Review)
Abstract
Endocannabinoids: a new class of vasoactive substances:
M.D. Randall & D.A. Kendall; TIPS
19
, 55 (1998), (Review)
Abstract
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments:
V. Di Marzo, et al.; Lipids
34
, S319 (1999), (Review)
Abstract
Anandamide: a candidate neurotransmitter heads for the big leagues:
D.W. Self; Nat. Neurosci.
2
, 303 (1999), (Review)
Abstract
New perspectives on enigmatic vanilloid receptors
:
A. Szallasi & V. Di Marzo; TINS
23
, 491 (2000), (Review)
Abstract
Anandamide: some like it hot
:
V. Di Marzo, et al.; TIPS
22
, 346 (2001), (Review)
Abstract
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes:
J. Joseph, et al.; Cancer Immunol. Immunother.
53
, 723 (2004)
Abstract
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways:
V.A. Movsesyan, et al.; Cell Death Differ.
11
, 1121 (2004)
Abstract
Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1:
E. Contassot, et al.; J. Neuropathol. Exp. Neurol.
63
, 956 (2004)
Abstract
Preferred conformations of endogenous cannabinoid ligand anandamide:
J.Z. Chen, et al.; Life Sci.
76
, 2053 (2005)
Abstract
The cardiovascular actions of anandamide: more targets?:
M.D. Randall; Br. J. Pharmacol.
145
, 565 (2005)
Abstract
;
Full Text
Accumulation of anandamide: Evidence for cellular diversity:
C.J. Hillard and A. Jarrahian; Neuropharmacology
48
, 1072 (2005)
Abstract
Anandamide as an intracellular messenger regulating ion channel activity:
M. van der Stelt and V. Di Marzo; Prostaglandins Other Lipid Mediat.
77
, 111 (2005)
Abstract
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism:
N.J. Underdown, et al.; Br. J. Pharmacol.
146
, 809 (2005)
Abstract
Anandamide inhibits adhesion and migration of breast cancer cells:
C. Grimaldi, et al.; Exp. Cell Res.
312
, 363 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Endocannabinoids
•
MAPK Pathway Activators
•
Apoptosis Inducers & Inhibitors Other Products
•
Endovanilloids
•
NF-kB Pathway Inhibitors
ALX-430-115
Revised 14-Aug-08
Aspirin
SYNONYMS
Acetylsalicylic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
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ALX-430-115-G005
5 g
10.00 USD
Product Specification
FORMULA:
C
9
H
8
O
4
MW:
180.2
CAS NUMBER:
50-78-2
MERCK INDEX:
14:
851
RTECS:
VO0700000
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Stable for at least 2 years when stored at room temperature. Keep aqueous solutions on ice and use within 30 minutes. Unstable in basic solutions pH>7.4.
HAZARD:
HARMFUL.
Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin:
E. Kopp & S. Ghosh; Science
265
, 956 (1994)
Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation:
M. Grilli, et al.; Science
274
, 1383 (1996)
Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta:
M.J. Yin, et al.; Nature
396
, 77 (1998)
Abstract
The pleiotropic functions of aspirin: mechanisms of action:
A.R. Amin, et al.; Cell Mol. Life Sci.
56
, 305 (1999)
Abstract
Further Categories Containing This Product:
COX Inhibitors
•
NF-kB Pathway Inhibitors
•
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
ALX-270-219
Revised 15-May-07
BAY 11-7082
SYNONYMS
(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-219-M010
10 mg
45.00 USD
ALX-270-219-M050
50 mg
190.00 USD
Product Specification
FORMULA:
C
10
H
9
NO
2
S
MW:
207.3
CAS NUMBER:
195462-67-7
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.
Product Specific Literature References
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo:
J.W. Pierce, et al.; J. Biol. Chem.
272
, 21096 (1997)
Abstract
;
Full Text
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells:
S.A. Keller, et al.; Blood
96
, 2537 (2000)
Abstract
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways:
M.M. Remacle-Bonnet, et al.; Cancer Res.
60
, 2007 (2000)
Abstract
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis:
F. Thevenod, et al.; J. Biol. Chem.
275
, 1887 (2000)
Abstract
;
Full Text
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E:
V. Petegnief, et al.; Neuroscience
104
, 223 (2001)
Abstract
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death:
T.M. Kauppinen & R.A. Swanson; J. Immunol.
174
, 2288 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
ALX-270-220
Revised 04-Nov-05
BAY 11-7085
SYNONYMS
(E)-3-(
t
-Butylphenylsulfonyl)-2-propenenitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-220-M010
10 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
15
NO
2
S
MW:
249.3
CAS NUMBER:
196309-76-9
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO or ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Has biological properties very similar to those of BAY 11-7082 (Prod. No.
ALX-270-219
). In addition, the product exhibits potent anti-inflammatory properties
in vivo
.
Product Specific Literature References
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
:
J.W. Pierce, et al.; J. Biol. Chem.
272
, 21096 (1997)
Abstract
;
Full Text
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis:
U. Koedel, et al.; J. Infect Dis.
182
, 1437 (2000)
Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E:
V. Petegnief, et al.; Neuroscience
104
, 223 (2001)
Abstract
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
ALX-350-277
Revised 03-Apr-08
Betulinic acid (high purity)
SYNONYMS
3β-Hydroxy-20(29)-lupaene-28-oic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-277-M005
5 mg
32.00 USD
ALX-350-277-M025
25 mg
95.00 USD
ALX-350-277-M100
100 mg
290.00 USD
Product Specification
FORMULA:
C
30
H
48
O
3
MW:
456.7
CAS NUMBER:
472-15-1
SOURCE/HOST:
Isolated from
Platanus acerifolia
(plane) tree bark.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
IRRITANT.
Product Description
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator.
Product Specific Literature References
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids:
T. Fujioka, et al.; J. Nat. Prod.
57
, 243 (1994)
Abstract
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis:
E. Pisha, et al.; Nat. Med.
1
, 1046 (1995)
Abstract
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents:
Y. Kashiwada, et al.; J. Med. Chem.
39
, 1016 (1996)
Abstract
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors:
S. Fulda, et al.; Cancer Res.
57
, 4956 (1997)
Abstract
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives:
F. Hashimoto, et al.; Bioorg. Med. Chem.
5
, 2133 (1997)
Abstract
Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma:
M. Rieber & M. Strasberg Rieber; DNA Cell Biol.
17
, 399 (1998)
Abstract
Betulinic acid induces apoptosis in human neuroblastoma cell lines:
M.L. Schmidt, et al.; Eur. J. Cancer
33
, 2007 (1997)
Abstract
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid:
S. Fulda, et al.; J. Biol. Chem.
273
, 33942 (1998)
Abstract
;
Full Text
Betulinic acid inhibits aminopeptidase N activity:
M.F. Melzig & H. Bormann; Planta Med.
64
, 655 (1998)
Abstract
Correspondence re: S. Fulda et al., Betulinic acid triggers CD95 (Apo1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 57: 4956, 1997:
M. Rieber & M. Strasberg Rieber; Cancer. Res.
58
, 5876 (1998)
Abstract
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells:
S. Fulda, et al.; Int. J. Cancer
82
, 435 (1999)
Abstract
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing:
W. Wick, et al.; J Pharmacol. Exp. Ther.
289
, 1306 (1999)
Abstract
;
Full Text
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells:
E. Selzer, et al.; J. Invest. Dermatol.
114
, 935 (2000)
Abstract
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9:
Y. Takada & B.B. Aggarwal; J. Immunol.
171
, 3278 (2003)
Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid:
D. Poeckel, et al.; Br. J. Pharmacol.
146
, 514 (2005)
Abstract
Betulinic acid and its derivatives: a review on their biological properties:
P. Yogeeswari and D. Sriram; Curr. Med. Chem.
12
, 657 (2005), Review
Abstract
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica:
S. Wada & R. Tanaka; Chem. Biodivers.
2
, 689 (2005)
Abstract
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy:
H. Kasperczyk, et al.; Oncogene
24
, 6945 (2005)
Abstract
Activation and inhibition of the proteasome by betulinic acid and its derivatives:
L. Huang, et al.; FEBS Lett.
581
, 4955 (2007)
Abstract
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription
•
Natural Products - NF-kB Pathway Inhibitors
•
MPTP [Mitochondrial Transition Pore] / Related Products
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
•
NF-kB Pathway Inhibitors
•
Natural Products - Antiviral / anti-HIV Agents
•
Antitumor Agents (Apoptosis Inducers)
•
HIV / AIDS / Related Products
ALX-350-298
Revised 03-Apr-08
Betulinic acid (~95%)
SYNONYMS
3β-Hydroxy-20(29)-lupaene-28-oic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-298-M100
100 mg
55.00 USD
ALX-350-298-M500
500 mg
180.00 USD
ALX-350-298-G001
1 g
290.00 USD
Product Specification
FORMULA:
C
30
H
48
O
3
MW:
456.7
CAS NUMBER:
472-15-1
SOURCE/HOST:
Isolated from
Platanus acerifolia
(plane tree) bark.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator.
Product Specific Literature References
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids:
T. Fujioka, et al.; J. Nat. Prod.
57
, 243 (1994)
Abstract
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis:
E. Pisha, et al.; Nat. Med.
1
, 1046 (1995)
Abstract
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents:
Y. Kashiwada, et al.; J. Med. Chem.
39
, 1016 (1996)
Abstract
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors:
S. Fulda, et al.; Cancer Res.
57
, 4956 (1997)
Abstract
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives:
F. Hashimoto, et al.; Bioorg. Med. Chem.
5
, 2133 (1997)
Abstract
Betulinic acid induces apoptosis in human neuroblastoma cell lines:
M.L. Schmidt, et al.; Eur. J. Cancer
