• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Ion Channels & Transporters Other Products
You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products > Ion Channels & Transporters Other Products
Toolbar - View Selection
 
Items 6 of 6
ALX-210-785/1 Revised 27-Mar-08
Polyclonal Antibody to Voltage-dependent Anion Channel
Add to Clipboard
SYNONYMS anti-VDAC PAb
anti-Mitochondrial Porin PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY MPTP [Mitochondrial Transition Pore] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-785/1-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to a part (CNDGTEFGGSIYQK) of C-terminal human VDAC (voltage-dependent anion channel) with an added N-terminal cysteine. This sequence is completely conserved between isoforms 1, 2 and 3 of human, mouse and rat VDAC.
SPECIFICITY: Recognizes rat VDAC. Detects a band of ~31kDa by Western blot.
APPLICATION: Western Blot (2µg/ml)
Note: Not recommended for Immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-170-002.
Product Specific Literature References
Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response: J. Liu, et al.; Mol. Cancer Res. 1, 892 (2003) Abstract; Full Text
Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry: M.D. Johnson, et al.; J. Biol. Chem. 279, 26685 (2004) Abstract; Full Text
Modulation of mitochondrial transition pore components by thyroid hormone: E. Yehuda-Shnaidman, et al.; Endocrinology 146, 2462 (2005) Abstract; Full Text
Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria: M.R. Brown, et al.; J. Biol. Chem. 281, 11658 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Sequence information of human VDAC: Swiss Prot Accession Number P21796. http://www.expasy.ch/cgi-bin/niceprot.pl?P21796
General Literature References
The mitochondrial permeability transition pore and its role in cell death: M. Crompton; Biochem. J. 341 (Pt 2), 233 (1999), Review Abstract; Full Text
Further Categories Containing This Product:
Ion Channels & Transporters Other ProductsPolyclonal Antibodies
 
 
ALX-350-001 Revised 05-Apr-08
Forskolin
Add to Clipboard
SYNONYMS Colforsin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-001-M001   1 mg 20.00 USD Add To Cart
ALX-350-001-M005   5 mg 52.00 USD Add To Cart
ALX-350-001-M010   10 mg 85.00 USD Add To Cart
ALX-350-001-M025   25 mg 185.00 USD Add To Cart
ALX-350-001-M050   50 mg 325.00 USD Add To Cart
Product Specification
FORMULA: C22H34O7
MW: 410.5
CAS NUMBER: 66575-29-9
MERCK INDEX: 14: 2476
SOURCE/HOST: Isolated from Coleus forskohlii.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to green crystals.
SOLUBILITY: Soluble in ethyl acetate (10mg/ml), anhydrous DMSO (5mg/ml) or 100% ethanol (6mg/ml). DMSO is the recommended solvent for activation of cAMP.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 4 months when stored at +4°C.

Product Description
Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors.
Product Specific Literature References
Forskolin: a unique diterpene activator of cyclic AMP-generating systems: K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981), Review Abstract
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells: J.C. Henquin, et al.; Endocrinology 112, 2218 (1983) Abstract
Pharmacology and inotropic potential of forskolin in the human heart: M.R. Bristow, et al.; J. Clin. Invest. 74, 212 (1984) Abstract
Forskolin and antidiuretic hormone stimulate a Ca2+-activated K+ channel in cultured kidney cells: S.E. Guggino, et al.; Am. J. Physiol. 249, F448 (1985) Abstract
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro: U.H. Lerner, et al.; Biochem J. 240, 529 (1986) Abstract
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?: A. Laurenza, et al.; Trends Pharmacol. Sci. 10, 442 (1989), Review Abstract
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle: A. Abe & H. Karaki; J. Pharmacol. Exp. Ther. 249, 895 (1989) Abstract
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors: M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992) Abstract
The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release: J.T. Christenson, et al.; Vasa 24, 56 (1995) Abstract
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling: P.A. Insel & R.S. Ostrom; Cell Mol. Neurobiol. 23, 305 (2003), Review Abstract
Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells: M. Harada, et al.; Pharmazie 62, 291 (2007) Abstract
 
 
ALX-350-106 Revised 29-Nov-07
Ampullosporin A
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-106-M001   1 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA: C77H127N19O19
MW: 1623.0
SOURCE/HOST: Antibiotic isolated from Sepedonium ampullosporum.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
Product Description
Peptaibol-type polypeptide. Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.
Product Specific Literature References
Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice: M. Ritzau, et al.; J. Antibiot. 50, 722 (1997) Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics: P. Grigoriev, et al.; Bioelectrochemistry 44, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A: P. Grigoriev, et al.; Bioelectrochemistry 57, 119 (2002) Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A: H.H. Nguyen, et al.; J. Med. Chem. 45, 2781 (2002) Abstract
Crystal structure and conformational analysis of ampullosporin A: M. Kronen, et al.; J. Pept. Sci. 9, 729 (2003) Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I: T.N. Kropacheva, et al.; Biochim. Biophys. Acta 1715, 6 (2005) Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model: H. Krugel, et al.; J. Neurochem. 97, Suppl. 1, 74 (2006) Abstract
Further Categories Containing This Product:
PeptidesAlzheimer Research Other ProductsIon Channels & Transporters Other Products
 
 
ALX-350-251 Revised 23-Oct-07
(R)-Roscovitine
Add to Clipboard
SYNONYMS 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-251-M001   1 mg 30.00 USD Add To Cart
ALX-350-251-M005   5 mg 110.00 USD Add To Cart
ALX-350-251-M050   50 mg 450.00 USD Add To Cart
Inquire
Product Specification
FORMULA: C19H26N6O
MW: 354.5
CAS NUMBER: 186692-46-6
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, DMSO or methanol; moderately soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and selective inhibitor of CDKs. Selective for CDK1/cyclin B kinase (IC50=450nM) [2], CDK2 (IC50=700nM) [4] and CDK5/p35 (IC50=160nM) [4,5]. More potent than olomoucine (Prod. No. ALX-350-013). Inhibits M phase promoting factor (MPF) kinase activity. Has effects on calcium channel gating.
Product Specific Literature References
[1] Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis: B. Rudolph, et al.; EMBO J. 15, 3065 (1996) Abstract
[2] Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine: W.F. De Azvedo, et al.; Eur. J. Biochem. 243, 518 (1997) Abstract
[3] Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997) Abstract
[4] Chemical inhibitors of cyclin-dependent kinases: L. Meijer and S.H. Kim; Meth. Enzymol. 283, 113 (1997) Abstract
[5] Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5: L. Meijer, et al.; Eur. J. Biochem. 243, 527 (1997) Abstract
[6] Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist: J.W. Pippin, et al.; J. Clin. Invest. 100, 2512 (1997) Abstract
[7] Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine: J.S. Yakisich, et al.; BBRC 243, 674 (1998) Abstract
[8] The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998) Abstract
[9] Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia: N. Sankrithi & A. Eskin; J. Neurochem. 72, 605 (1999) Abstract
[10] Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin- dependent kinases: L.M. Schang, et al.; J. Virol. 73, 2161 (1999) Abstract
[11] Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials: L. Meijer & E. Raymond; Acc. Chem. Res. 36, 417 (2003), (Review) Abstract
[12] The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003) Abstract
[13] Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004) Abstract
[14] Roscovitine targets, protein kinases and pyridoxal kinase: S. Bach, et al.; J. Biol. Chem. 280, 31208 (2005) Abstract
[15] The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction: S. Cho & S.D. Meriney; Eur. J. Neurosci. 23, 3200 (2006) Abstract
[16] Roscovitine differentially affects CaV2 and Kv channels by binding to the open state: Z. Buraei, et al.; Neuropharmacology 52, 883 (2007) Abstract
Further Categories Containing This Product:
Ion Channels & Transporters Other Products
 
 
ALX-430-160 Revised 07-Aug-08
Lamotrigine
Add to Clipboard
SYNONYMS 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
LTG
BW-430C
Lamictal
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ion Channels & Transporters Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-160-M025   25 mg 40.00 USD Add To Cart
ALX-430-160-M100   100 mg 120.00 USD Add To Cart
ALX-430-160-M500   500 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C9H7Cl2N5
MW: 256.1
CAS NUMBER: 84057-84-1
MERCK INDEX: 14: 5353
RTECS: XY5850700
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (60°C, 20mg/ml) or dimethyl formamide; slightly soluble in anhydrous ethanol or dilute hydrochloric acid; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
IDENTITY: Identity determined by IR.

Product Description
Blocks voltage-gated sodium channels. Inhibits the release of glutamate. Neuroprotective. Anticonvulsant.
Product Specific Literature References
Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam: A.F. Cohen, et al.; Br. J. Clin. Pharmacol. 20, 619 (1985) Abstract; Full Text
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats: A.A. Miller, et al.; Epilepsia 27, 483 (1986) Abstract
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action: M.J. Leach, et al.; Epilepsia 27, 490 (1986) Abstract
Acute effects of lamotrigine (BW430C) in persons with epilepsy: C.D. Binnie, et al.; Epilepsia 27, 248 (1986) Abstract
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy: S. Jawad, et al.; Br. J. Clin. Pharmacol. 22, 191 (1986) Abstract; Full Text
Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans: A.F. Cohen, et al.; Clin. Pharmacol. Ther. 42, 535 (1987) Abstract
Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder: X. Xie & R.M. Hagan; Neuropsychobiology 38, 119 (1998) Abstract
A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group: J.R. Calabrese, et al.; J. Clin. Psychiatry 60, 79 (1999) Abstract
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception: T.M. Laughlin, et al.; J. Pharmacol. Exp. Ther. 302, 1168 (2002) Abstract; Full Text
Review of lamotrigine and its clinical applications in epilepsy: H. Choi & M.J. Morrell; Expert Opin. Pharmacother. 4, 243 (2003) Abstract
Lamotrigine in the treatment of bipolar disorder: Z. Bhagwagar & G.M. Goodwin; Expert Opin. Phamacother. 6, 1401 (2005) Abstract
A novel drug binding site on voltage-gated sodium channels in rat brain: D.R. Ridall, et al.; Mol. Pharmacol. 69, 278 (2006) Abstract; Full Text
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders: S. Malik, et al.; Expert Rev. Neurother. 6, 1609 (2006) Abstract
Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice: E. Lagrue, et al.; Pediatr. Res. 62, 14 (2007) Abstract
Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy: G. Papazisis, et al.; Int. J. Neuropsychopharmacol. 11, 321 (2008) Abstract
Further Categories Containing This Product:
Glutamate Transporters / Related Products
 
 
ALX-550-086 Revised 09-Oct-06
Chlorothiazide
Add to Clipboard
SYNONYMS 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ion Channels & Transporters Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-086-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C7H6N3ClO4S2
MW: 295.7
CAS NUMBER: 58-94-6
MERCK INDEX: 14: 2168
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Carbonic anhydrase inhibitor. Diuretic. Antihypertensive.
 
 

Your items will be kept only for the duration of your visit.