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Antibiotics - Antifungal
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ALX-380-116 Revised 07-Apr-08
Hypothemycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-116-C250   250 µg 140.00 USD Add To Cart
ALX-380-116-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C19H22O8
MW: 378.4
CAS NUMBER: 76958-67-3
SOURCE/HOST: Isolated from Phoma sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or acetone; insoluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies.
Product Specific Literature References
Metabolites of pyrenomycetes XIII: Structure of (+) hypothemycin, an antibiotic macrolide from hypomyces trichothecoides: M.S.R. Nair & S.T. Carey; Tetrahedron Lett. 21, 2011 (1980)
Metabolites of pyrenomycetes. XIV: Structure and partial stereochemistry of the antibiotic macrolides hypothemycin and dihydrohypothemycin: M.S.R. Nair, et al.; Tetrahedron 37, 2445 (1981)
Revised structure and stereochemistry of hypothemycin: T. Agatsuma et al.; Chem. Pharm. Bull. 41, 373 (1993)
Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor: H. Tanaka, et al.; Jpn. J. Cancer Res. 90, 1139 (1999) Abstract
Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation: R. Camacho, et al.; Immunopharmacology 44, 255 (1999) Abstract
Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway: H. Sonoda, et al.; Life Sci. 65, 381 (1999) Abstract
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK: A. Zhao, et al.; J. Antibiot. 52, 1086 (1999) Abstract
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides: A. Schirmer, et al.; PNAS 103, 4234 (2006) Abstract; Full Text
Chemistry and biology of resorcylic acid lactones: N. Winssinger, et al.; Chem. Commun. (Camb). 1, 22 (2007), (Review) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Antibiotics - Protein Kinase Inhibitors • Tyrosine Kinase Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics • Antibiotics - Proteasome / Ubiquitin Modulators • Ubiquitination Other Products • CDKs & Cyclins Other Products • Ras Signalling Pathway Other Products
 
 
ALX-380-117 Revised 10-Apr-07
UK-1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-117-C250   250 µg 140.00 USD Add To Cart
ALX-380-117-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C22H14N2O5
MW: 386.4
CAS NUMBER: 151271-53-3
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Antifungal. Inhibitor of topoisomerase II (Topo II). Mg2+- and Zn2+-dependent DNA binding agent. Displays a wide spectrum of potent anticancer activities.
Product Specific Literature References
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties: M. Ueki, et al.; J. Antibiot. 46, 1089 (1993) Abstract
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation: K. Shibata, et al.; J. Antibiot. 46, 1095 (1993) Abstract
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. III. Antibacterial action of demethyl UK-1: M. Ueki and M. Taniguchi; J. Antibiot. 50, 788 (1997) Abstract
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. IV. Antifungal action of methyl UK-1: M. Ueki, et al.; J. Antibiot. 51, 883 (1998) Abstract
The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II: M.B. Reynolds, et al.; Bioorg. Chem. 27, 326 (1999)
Evaluation of complexation of metal-mediated DNA-binding drugs to oligonucleotides via electrospray ionization mass spectrometry: M.L. Reyzer, et al.; Nucl. Acids Res. 29, E103 (2001) Abstract; Full Text
Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1: D. Kumar, et al.; Bioorg. Med. Chem. 10, 3997 (2002) Abstract
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs: B.B. Wang, et al.; Bioorg. Med. Chem. Lett. 14, 3221 (2004) Abstract
Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles: O. Temiz-Arpaci, et al.; Arch. Pharm. 338, 105 (2005) Abstract
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles: S.T. Huang, et al.; Bioorg. Med. Chem. 14, 6106 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-380-121 Revised 20-Nov-08
Aspyrone
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SYNONYMS 5,6-Dihydro-5-hydroxy-6-methyl-3-(3-methyloxiranyl)-2H-pyran-2-one
3-(1,2-Epoxypropyl)-5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-121-M001   1 mg 60.00 USD Add To Cart
ALX-380-121-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H12O4
MW: 184.2
CAS NUMBER: 17398-00-4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Antibiotic with nematicidal, insecticidal, antibacterial and antifungal activity. Related to aspinonene (Prod. No. ALX-380-132).
Product Specific Literature References
A new metabolite of Aspergillus melleus: S.D. Mills & W.B. Turner; J. Chem. Soc. (C) 1967, 2242 (1967)
Production of 3-(1,2-Epoxypropyl)-5,6-dihydro-5-hydroxy-6-methylpyran-2-one by Aspergillus ochraceus Wilhelm: J.H. Moore, et al.; J. Agr. Food Chem. 22, 697 (1974) Abstract
J.S.E. Holker, et al.; J.C.S. Perkin Trans. I 1981, 1397 (1981)
17O NMR in biosynthetic studies: aspyrone, asperlactone and isoasperlactone, metabolites of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1106 (1991)
Biosynthesis of aspyrone, a metabolite of Aspergillus melleus: advanced precursor studies to identify the product of the polyketide synthase: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1108 (1991)
The polyketide synthase (PKS) of aspyrone biosynthesis: evidence for the enzyme bound intermediates from incorporation studies with N-acetylcysteamine thioesters in intact cells of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1110 (1991)
Effect of fungal metabolites and some derivatives against Tribolium castaneum (Herbst) and Nezara viridula (L.): M. Balcells, et al.; Pestic. Sci. 45, 319 (1995)
Synthesis of chiral aspyrone, a multi-functional dihydropyranone antibiotic: T. Sugiyama, et al.; Biosci. Biotech. Biochem. 59, 1921 (1995) Abstract
Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleus: Y. Kimura, et al.; Biosci. Biotech. Biochem. 60, 1375 (1996)
Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivatives: M. Torres, et al.; Pestic. Sci. 53, 9 (1998)
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ALX-380-122 Revised 03-Apr-08
Asperlactone
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SYNONYMS 5-(1-Hydroxyethyl)-3-(3-methyloxiranyl)-2(5H)-furanone
5-(1-Hydroxyethyl)-3-(2,3-epoxypropyl)butenolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-122-M001   1 mg 60.00 USD Add To Cart
ALX-380-122-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H12O4
MW: 184.2
CAS NUMBER: 76375-62-7
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Antibiotic with nematicidal, insecticidal, antibacterial and antifungal activity.
Product Specific Literature References
New polyketide metabolites from Aspergillus melleus: structural and stereochemical studies: M.J. Garson, et al.; J.C.S. Perkin Trans. I 1984, 1021 (1984)
Biosynthesis of fungal metabolites: asperlactone and its relationship to other metabolites of Aspergillus melleus: R.G. Brereton, et al.; J.C.S. Perkin Trans. I 1984, 1027 (1984)
17O NMR in biosynthetic studies: aspyrone, asperlactone and isoasperlactone, metabolites of Aspergillus melleus: J. Staunton & A.C. Sutkowski; J.C.S. Chem. Commun. 1991, 1106 (1991)
Effect of fungal metabolites and some derivatives against Tribolium castaneum (Herbst) and Nezara viridula (L.): M. Balcells, et al.; Pestic. Sci. 45, 319 (1995)
Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleus: Y. Kimura, et al.; Biosci. Biotech. Biochem. 60, 1375 (1996)
Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivatives: M. Torres, et al.; Pestic. Sci. 53, 9 (1998)
Characterization and regulation of new secondary metabolites from Aspergillus ochraceus M18 obtained by UV mutagenesis: G. Awad, et al.; Can. J. Microbiol. 51, 59 (2005) Abstract; Full Text
 
 
ALX-380-128 Revised 30-Jun-08 New product
MM 47755
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SYNONYMS 6-Desoxy-8-O-methylrabelomycin
(-)-3,4-Dihydro-3-hydroxy-8-methoxy-3-methylbenz(a)anthracene-1,7,12(2H)-trione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-128-M001   1 mg 90.00 USD Add To Cart
ALX-380-128-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 117620-87-8
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Angucyclinone. Displays antibacterial and antifungal activity.
Product Specific Literature References
6-Deoxy-8-O-methylrabelomycin and 8-O-methylrabelomycin from a Streptomyces species: Y. Shigihara, et al.; J. Antibiot. 41, 1260 (1988) Abstract
MM 47755, a new benz[a]anthracene antibiotic from a streptomycete: M.L. Gilpin, et al.; J. Antibiot. 42, 627 (1989) Abstract
Remote Stereochemical Control in Asymmetric Diels - Alder Reactions: Synthesis of the Angucycline Antibiotics, (-)-Tetrangomycin and MM 47755: J.S. Landells, et al.; THL 44, 5193 (2003)
Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755): C. Kesenheimer & U. Groth; Org. Lett. 8, 2507 (2006) Abstract
Angucyclinone antibiotics: total syntheses of YM-181741, (+)-ochromycinone, (+)-rubiginone B2, (-)-tetrangomycin, and MM-47755: K.P. Kaliappan & V. Ravikumar; J. Org. Chem. 72, 6116 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-129 Revised 30-Jun-08 New product
Naphthomycin B
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SYNONYMS 2-Demethylnaphthomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-129-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C39H44ClNO9
MW: 706.2
CAS NUMBER: 86825-88-9
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Ansamycin. Displays antibacterial and antifungal activity.
Product Specific Literature References
Isolation and structural elucidation of naphthomycins B and C: W. Keller-Schierlein, et al.; J. Antibiot. 36, 484 (1983) Abstract
Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces: H.J. Schiewe & A. Zeeck; J. Antibiot. 52, 635 (1999) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-130 Revised 15-Sep-08 New product
Isofusidienol A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-130-M001   1 mg 90.00 USD Add To Cart
ALX-380-130-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C16H12O6
MW: 300.3
SOURCE/HOST: Isolated from Chalara sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Chromone-3-oxepine. Displays antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Specific Literature References
Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp: S. Lösgen, et al.; Eur. J. Org. Chem. 2008, 698
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-136 Revised 20-Nov-08 New product
Reductiomycin
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SYNONYMS AM-6201
S 551II
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-136-M001   1 mg 90.00 USD Add To Cart
ALX-380-136-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C14H15NO6
MW: 293.3
CAS NUMBER: 68748-55-0
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98%
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic. Shows antibacterial, antifungal, antiviral and antitumor activity.
Product Specific Literature References
Reductiomycin, a new antibiotic. I. Taxonomy, fermentation, isolation, characterization and biological activities: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 649 (1981) Abstract
Reductiomycin, a new antibiotic. II. Structural elucidation by spectroscopic studies: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 654 (1981) Abstract
Structure of antitumor alkaloid AM-6201: Y. Konda, et al.; J. Antibiot. (Tokyo) 34, 1222 (1981) Abstract
The alkaloid AM-6201 from Streptomyces xanthochromogenus: M. Onda, et al.; Chem. Pharm. Bull. 30, 1210 (1982)
Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus: H. Cho, et al.; JACS 115, 12296 (1993) Abstract
Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products: F. Li, et al.; Org. Lett. 9, 2923 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • Antibiotics - Antiviral / Anti-HIV • Alkaloids
 
 
ALX-380-137 Revised 20-Nov-08 New product
Acetomycin
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SYNONYMS NSC350598
3-Acetyl-5-(acetyloxy)dihydro-3,4-dimethyl-2(3H)furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-137-M001   1 mg 85.00 USD Add To Cart
ALX-380-137-M005   5 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C10H14O5
MW: 214.2
CAS NUMBER: 510-18-9
SOURCE/HOST: Isolated from Streptomyces ramulosus.
PURITY: ≥98%
APPEARANCE: White to off-white crystals.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic with antibacterial, antifungal and antiprotozoal activity. Cytotoxic against several tumor cell lines in vitro.
Product Specific Literature References
The structure of acetomycin. Spectroscopic characterization and X-ray analysis of a bromo derivative: H. Uhr, et al.; J. Antibiot. (Tokyo) 38, 1684 (1985) Abstract
Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo: S.W. Mamber, et al.; J. Antibiot. (Tokyo) 40, 73 (1987) Abstract
Biological effects of acetomycin. II. Inactivation by esterases in vitro: S.W. Mamber, et al.; J. Antibiot. (Tokyo) 40, 77 (1987) Abstract
The structure and absolute configuration of acetomycin: F.H. Cano, et al.; Acta Crystallogr. C. 44, 919 (1988) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-200 Revised 31-Jul-08
Thiolutin
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SYNONYMS 6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one
Farcinicine
Acetopyrrothine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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