ALEXIS Biochemicals: Verruculogen

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ALX-380-222

Revised 19-Aug-08

UCN-01
SYNONYMS	7-Hydroxystaurosporine Staurosporine, 7-Hydroxy-
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Staurosporine / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-222-MC25		0.25 mg	85.00 USD
ALX-380-222-M001		1 mg	265.00 USD

Product Specification

FORMULA:	C₂₈H₂₆N₄O₄
MW:	482.5
CAS NUMBER:	112953-11-4
RTECS:	KC6600010
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5345.
PURITY:	≥98% (HPLC)
APPEARANCE:	Light tan to light yellow solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.

Product Specific Literature References

[1] UCN-01, a selective inhibitor of protein kinase C from Streptomyces: I. Takahashi, et al.; J. Antibiot. (Tokyo) 40, 1782 (1987) Abstract
[2] UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities: I. Takahashi, et al.; J. Antibiot. (Tokyo) 42, 571 (1989) Abstract
[3] UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line: K. Kawakami, et al.; BBRC 219, 778 (1996) Abstract
[4] UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?: S. Akinaga, et al.; Anticancer Drug Des. 15, 43 (2000) Abstract
[5] UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway: M.M. Facchinetti, et al.; Cancer Res. 64, 3629 (2004) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

Note: Some interconversion of UCN-01 to UCN-02 may occur under acidic HPLC conditions (see [2]).

Further Categories Containing This Product:

Antibiotics - Apoptosis Inducers & Inhibitors • PKC Inhibitors • CDK & Cyclin Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Antibiotics for Cell Cycle Research • Antibiotics - Protein Kinase Inhibitors • Antitumor Antibiotics • Alkaloids

ALX-380-206

Revised 19-Aug-08

UCN-02
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Staurosporine / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-206-MC25		0.25 mg	85.00 USD
ALX-380-206-M001		1 mg	265.00 USD

Product Specification

FORMULA:	C₂₈H₂₆N₄O₄
MW:	482.5
CAS NUMBER:	121569-61-7
RTECS:	KC6600000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5345.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to pale yellow solid.
SOLUBILITY:	Soluble in ethyl acetate, 100% ethanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibitor of protein kinase C (PKC) and protein kinase A (PKA). Although less selective than its isomer UCN-01 (Prod. No. ALX-380-222), UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Product Specific Literature References

[1] UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities: I. Takahashi, et al.; J. Antibiot. (Tokyo) 42, 571 (1989) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Note: Some interconversion of UCN-02 to UCN-01 may occur under acidic HPLC conditions (see [1]).

Further Categories Containing This Product:

Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Antibiotics • PKC Inhibitors • Antibiotics - Protein Kinase Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • CDK & Cyclin Inhibitors • Antibiotics for Cell Cycle Research • Alkaloids

ALX-380-056

Revised 10-May-07

Verruculogen
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-056-M001		1 mg	60.00 USD
ALX-380-056-M005		5 mg	225.00 USD

Product Specification

FORMULA:	C₂₇H₃₃N₃O₇
MW:	511.2
CAS NUMBER:	12771-72-1
RTECS:	JH4920000
SOURCE/HOST:	Isolated from Penicillium verruculosum.
PURITY:	≥96%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in ethyl acetate, DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	VERY TOXIC.

Product Description

Neurotoxin that acts as an inhibitor of the M phase of the mammalian cell cycle. Inhibits Ca²⁺-activated K⁺ channels. Decreases GABA levels in CNS.

Product Specific Literature References

Tremorgenic indole alkaloids potently inhibit smooth muscle high- conductance calcium-activated potassium channels: H.H. Knaus, et al.; Biochemistry 33, 5819 (1994) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico- chemical properties and structures: C.B. Cui, et al.; J. Antibiot. (Tokyo) 49, 534 (1996) Abstract
Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.: I. Kosalec, et al.; Acta Pharm. 55, 357 (2005) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors / Related Products • Neurotoxins • Alkaloids • K+ Channel Blockers & Inhibitors

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