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ALX-340-038
Revised 08-Sep-08
Leukotriene B4
SYNONYMS
LTB
4
5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-340-038-C025
25 µg
170.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
71160-24-2
MERCK INDEX:
14:
5455
CONCENTRATION:
0.1mg/ml
PURITY:
≥97%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (1mg/ml). Solvents should be free of oxygen, transition metal ions, and redox active compounds.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.
Product Specific Literature References
Leukotriene B4 and inflammatory disease:
R.M. McMillan & S.J. Foster; Agents Actions
24
, 114 (1988)
Abstract
The PPARalpha-leukotriene B4 pathway to inflammation control:
P.R. Devchand, et al.; Nature
384
, 39 (1996)
Abstract
Leukotriene B4:
S.W. Crooks & R.A. Stockley; Int. J. Biochem. Cell Biol.
30
, 173 (1998), (Review)
Abstract
The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells:
M. Heimbürger & J. Palmblad; BBRC
249
, 371 (1998)
Abstract
Ligand selectivity of the peroxisome proliferator-activated receptor alpha:
Q. Lin, et al.; Biochemistry
38
, 185 (1999)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
ALX-340-043
Revised 08-Sep-08
Leukotriene C4
SYNONYMS
LTC
4
5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-043-C025
25 µg
157.00 USD
ALX-340-043-C050
50 µg
298.00 USD
ALX-340-043-C100
100 µg
563.00 USD
Product Specification
FORMULA:
C
30
H
47
N
3
O
9
S
MW:
625.8
CAS NUMBER:
72025-60-6
MERCK INDEX:
14:
5455
CONCENTRATION:
0.1mg/ml
PURITY:
≥97%
FORMULATION:
Liquid. Solution in ethanol:water (95:5).
SOLUBILITY:
50mg/ml soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (100µg/ml).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. We do not recommend storing aqueous solutions for more than one day.
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol:water (95:5) under a gentle stream of nitrogen and immediately add the solvent of choice.
ALX-270-090
Revised 14-May-03
Dapsone
SYNONYMS
4,4'-Diaminodiphenyl sulfone
DDS
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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ALX-270-090-G001
1 g
10.00 USD
ALX-270-090-G005
5 g
20.00 USD
Product Specification
FORMULA:
C
12
H
12
N
2
O
2
S
MW:
248.3
CAS NUMBER:
80-08-0
MERCK INDEX:
14:
2822
PURITY:
≥96%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
Leukotriene B
4
(LTB
4
)
antagonist. Inhibits LTB
4
induced lysozyme release.
Product Specific Literature References
Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels:
B.L. Maloff, et al.; Eur. J. Pharmacol.
158
, 85 (1988)
Abstract
ALX-340-021
Revised 04-Jun-08
MK-571 . sodium salt
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
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ALX-340-021-M005
5 mg
45.00 USD
ALX-340-021-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
26
H
26
ClN
2
O
3
S
2
. Na
MW:
514.1 . 23.0
CAS NUMBER:
115104-28-4
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to light yellow solid.
SOLUBILITY:
Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Leukotriene LTD4 receptor antagonist that potently inhibits MRP1.
Product Specific Literature References
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance
:
V. Gekeler, et al.; BBRC
208
, 345 (1995)
Abstract
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide
:
L. Vernhet, et al.; Biochem. Pharmacol.
61
, 1387 (2001)
Abstract
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
:
J. Liu, et al.; Mol. Pharmacol.
60
, 302 (2001)
Abstract
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?
:
K. Jones, et al.; Aids
15
, 1353 (2001)
Abstract
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells
:
U. Stein, et al.; Int. J. Cancer
97
, 751 (2002)
Abstract
Further Categories Containing This Product:
MDR Inhibitors
ALX-340-026
Revised 16-Jun-06
LY-171,883
SYNONYMS
1-[2-Hydroxy-3-propyl-4-[4-(1
H
-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antagonists
Ordering Information
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ALX-340-026-M010
10 mg
68.00 USD
Product Specification
FORMULA:
C
16
H
22
N
4
O
3
MW:
318.4
CAS NUMBER:
88107-10-2
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Organic stock solutions are stable for at least six months when stored at –20°C.
Product Description
Competitive leukotriene D
4
(LTD
4
) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist:
J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther.
233
, 148 (1985)
Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit:
A. Sala, et al.; Br. J. Pharmacol.
110
, 1206 (1993)
Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor:
P. Tontonoz, et al.; Cell
79
, 1147 (1994)
Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma:
B.M. Forman, et al.; Cell
83
, 803 (1995)
Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
ALX-430-063
Revised 10-Oct-07
Anthralin
SYNONYMS
Dithranol
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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ALX-430-063-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
14
H
10
O
3
MW:
226.2
CAS NUMBER:
1143-38-0
MERCK INDEX:
14:
684
RTECS:
CB8927000
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE MUTAGENIC. IRRITANT.
Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB
4
ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils:
J.M. Schröder; J. Invest. Dermatol.
87
, 624 (1986)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
Cancer Other Products
ALX-340-020
Revised 24-Nov-08
Prostaglandin F2α
SYNONYMS
Dinoprost
9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Prostaglandins & Prostaglandin Analogs
Ordering Information
Product Numbers:
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ALX-340-020-M001
1 mg
36.00 USD
ALX-340-020-M005
5 mg
162.00 USD
Product Specification
FORMULA:
C
20
H
34
O
5
MW:
354.5
CAS NUMBER:
551-11-1
PURITY:
≥99%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
100mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in aqueous buffers (10mg/ml in PBS, pH 7.2).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at –20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Widely distributed prostaglandin occurring in many species.
ALX-340-022
Revised 29-Aug-08
Prostaglandin J2, 15-Deoxy-Δ12,14-
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Prostaglandins & Prostaglandin Analogs
Ordering Information
Product Numbers:
Format:
Size:
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ALX-340-022-C500
500 µg
85.00 USD
ALX-340-022-M001
1 mg
150.00 USD
Product Specification
FORMULA:
C
20
H
28
O
3
MW:
316.4
CAS NUMBER:
87893-55-8, 89886-60-2
CONCENTRATION:
1mg/ml
PURITY:
≥97%
FORMULATION:
Liquid. Solution in mehtyl acetate.
SOLUBILITY:
20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 2.7mg/ml soluble in PBS, pH 7.2
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. May polymerize in basic solutions. Keep aqueous solutions on ice and use within 12 hours.
HAZARD:
IRRITANT. FLAMMABLE.
Product Description
Suggested natural ligand for the γ-isoform of the nuclear peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro:
F.A. Fitzpatrick and M.A. Wynalda; J. Biol. Chem.
258
, 11713 (1983)
Abstract
;
Full Text
9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma:
Y. Kikawa, et al.; PNAS
81
, 1317 (1984)
Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma:
B.M. Forman, et al.; Cell
83
, 803 (1995)
Abstract
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation:
S.A. Kliewer, et al.; Cell
83
, 813 (1995)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
ALX-340-025
Revised 11-Jul-08
8-iso Prostaglandin F2α
SYNONYMS
8-
epi
Prostaglandin F
2
α
8-Isoprostane
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Prostaglandins & Prostaglandin Analogs
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-025-M001
1 mg
162.00 USD
ALX-340-025-M005
5 mg
728.00 USD
Product Specification
FORMULA:
C
20
H
34
O
5
MW:
354.5
CAS NUMBER:
27415-26-5
PURITY:
≥99%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
100mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in aqueous buffers (10mg/ml in PBS, pH 7.2).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C. Stock solutions in organic solvents are stable for 6 months at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Potent vasoconstrictor in rat lung and kidney where its effects seem to be mediated through thromboxane receptors. However, evidence exists for a separate and distinct isoprostane receptor. It is also a mitogen in 3T3 cells and in vascular smooth muscle cells; may play a role in pulmonary oxygen toxicity. Thought to be formed via non-enzymatic, free-radical-induced oxidation of unsaturated fatty acids in membrane phospholipids.
Product Specific Literature References
Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells:
K. Hanasaki, et al.; Biochem. Pharmacol.
40
, 2535 (1990)
Abstract
Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ:
M. Banerjee, et al.; Am. J. Physiol.
263
, H660 (1992)
Abstract
Glomerular actions of a free radical-generated novel prostaglandin, 8- epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors:
K. Takahashi, et al.; J. Clin. Invest.
90
, 136 (1992)
Abstract
Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells:
M. Fukunaga, et al.; Am. J. Physiol.
264
, C1619 (1993)
Abstract
Role of nonenzymatically generated prostanoid, 8-iso-PGF2 alpha, in pulmonary oxygen toxicity:
C.A. Vacchiano & G.E. Tempel; J. Applied Physiol.
77
, 2912 (1994)
Abstract
Molecular and functional evidence for the distinct nature of F2- isoprostane receptors from those of thromboxane A2:
T. Yura, et al.; Adv. Prostaland. Thromb. Leukotr.
23
, 237 (1995)
Abstract
ALX-340-028
Revised 25-Aug-08
Prostaglandin E2
SYNONYMS
Dinoprostone
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Prostaglandins & Prostaglandin Analogs
Ordering Information
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ALX-340-028-M001
1 mg
28.00 USD
ALX-340-028-M005
5 mg
123.00 USD
ALX-340-028-M010
10 mg
218.00 USD
Product Specification
FORMULA:
C
20
H
32
O
5
MW:
