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Signal Transduction
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 Items 120-140 of 2953 Page 7 of 148 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-113 Revised 08-Apr-08
Phloretin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-113-M100   100 mg 37.00 USD Add To Cart
Product Specification
FORMULA: C15H14O5
MW: 274.3
CAS NUMBER: 60-82-2
MERCK INDEX: 14: 7326
PURITY: ≥98%
APPEARANCE: Off-white to beige solid.
SOLUBILITY: Soluble in acetone, DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.
Product Specific Literature References
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells: G. Benga, et al.; Eur. J. Cell Biol. 59, 219 (1992) Abstract
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes: J. Kitanaka, et al.; J. Neurochem. 60, 704 (1993) Abstract
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells: X. Wang, et al.; Biochem. J. 290, 249 (1993) Abstract
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res. 35, 141 (1994) Abstract
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett. 165, 167 (1994) Abstract
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology 134, 2410 (1994) Abstract
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci. 5, 699 (1994) Abstract
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr. 135, 172 (2005) Abstract
Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC 361, 208 (2007) Abstract
Further Categories Containing This Product:
Adiponectin [ACRP30] / Related Products • Adhesion Molecules & Receptors Other Products • PKC Inhibitors • Active Substances from Fruit and Vegetables
 
 
ALX-270-115 Revised 08-Dec-05
ONO-RS-082
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SYNONYMS 2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PLA2 Inhibitors
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ALX-270-115-M005   5 mg 40.00 USD Add To Cart
ALX-270-115-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H22ClNO3
MW: 371.9
CAS NUMBER: 99754-06-0
PURITY: ≥98%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for 3 months when stored at -20°C.
HANDLING: Do not freeze. Protect from light.

Product Description
Phospholipase A2 inhibitor. Inhibits epinephrine-stimulated thromboxane production in human platelets. Also blocks insulin secretion in pancreatic islets in response to glucose.
Product Specific Literature References
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H.S. Banga, et al.; PNAS 83, 9197 (1986) Abstract
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets: R.J. Konrad, et al.; Biochim. Biophys. Acta 1135, 215 (1992) Abstract
 
 
ALX-270-116 Revised 15-Jan-08
Quazinone
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SYNONYMS Ro 13-6438
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-116-M005   5 mg 45.00 USD Add To Cart
ALX-270-116-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C11H10ClN3O
MW: 235.7
CAS NUMBER: 70018-51-8
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (3mg/ml), 100% ethanol (1mg/ml) or water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective inhibitor of cGMP-specific phosphodiesterase. The product is not sterile.
Product Specific Literature References
Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties: M. Holck, et al.; J. Cardiovasc. Pharmacol. 6, 520 (1984) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
 
 
ALX-270-118 Revised 28-Jul-08
Ro 20-1724
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SYNONYMS 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-118-M050   50 mg 28.00 USD Add To Cart
ALX-270-118-M100   100 mg 45.00 USD Add To Cart
ALX-270-118-M250   250 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C15H22N2O3
MW: 278.4
CAS NUMBER: 29925-17-5
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (40mg/ml) or DMSO (200 mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
MELTINGPOINT: 126-127°C

Product Description
Selective, potent cAMP phosphodiesterase inhibitor. Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Product Specific Literature References
Structure-activity relationships for inhibitors of phosphodiesterase from erythrocytes and other tissues: H. Sheppard, et al.; Adv. Cycl. Nucl. Res. 1, 103 (1972) Abstract
Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'- monophosphate phosphodiesterases: H. Bergstrand, et al.; Mol. Pharmacol. 13, 38 (1977) Abstract
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia & A.R. Rhoads; Biochem. Pharmacol. 31, 665 (1982) Abstract
Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4: N.K. Hopkins, et al.; Biochim. Biophys. Acta 763, 276 (1983) Abstract
Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity: C. Lugnier, et al.; BBRC 113, 954 (1983) Abstract
Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils: P.M. Lad, et al.; Biochim. Biophys. Acta 846, 286 (1985) Abstract
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987) Abstract
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium: Y. Katano & M. Endoh; BBRC 167, 123 (1990) Abstract
A cell culture model of the blood-brain barrier: L.L. Rubin, et al.; J. Cell. Biol. 115, 1725 (1991) Abstract
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators: C.K. Derian, et al.; J. Immunol. 154, 308 (1995) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-270-119 Revised 09-Mar-06
Rolipram
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SYNONYMS 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-119-M005   5 mg 30.00 USD Add To Cart
ALX-270-119-M025   25 mg 115.00 USD Add To Cart
Product Specification
FORMULA: C16H21NO3
MW: 275.4
CAS NUMBER: 61413-54-5
MERCK INDEX: 14: 8251
RTECS: UY5749237
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Selective inhibitor of phosphodiesterase 4 (PDE4).
Product Specific Literature References
Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986) Abstract
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994) Abstract
 
 
ALX-270-120 Revised 30-Jul-08
Furegrelate sodium
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SYNONYMS U-63557A
Sodium furegrelate
PRODUCT LINE Inflammation
PRODUCT CATEGORY Thromboxanes / Related Products
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ALX-270-120-M010   10 mg 90.00 USD Add To Cart
ALX-270-120-M050   50 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C15H10NO3 . Na
MW: 252.2 . 23.0
CAS NUMBER: 85666-17-7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water (15mg/ml), methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. Before use, prepare a stock solution by dissolving the product in water. Stock solutions will be stable for at least 1 month if stored at 0°C in an oxygen-free environment.
IDENTITY: Identity determined by MS, 1H-NMR and 13C-NMR.

Product Description
Potent and selective orally active inhibitor of thromboxane A2 synthase.
Product Specific Literature References
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate: R.R. Gorman, et al.; Prostaglandins 26, 325 (1983) Abstract
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids: R.A. Johnson, et al.; J. Med. Chem. 29, 1461 (1986) Abstract
Pharmacokinetics of furegrelate after oral administration to normal humans: D.B. Lakings, et al.; Pharm. Res. 6, 53 (1989) Abstract
Thromboxane synthase activity and platelet function after furegrelate administration in man: J.S. Mohrland, et al.; J. Clin. Pharmacol. 29, 53 (1989) Abstract
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects: J.S. Mohrland, et al.; Eur. J. Clin. Pharmacol. 38, 485 (1990) Abstract
 
 
ALX-270-121 Revised 01-Dec-04
N-(3-Aminopropyl)cyclohexylamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-270-121-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C9H20N2
MW: 156.3
CAS NUMBER: 3312-60-5
PURITY: ≥97% (contains traces of water)
APPEARANCE: Pale yellow clear liquid. d = 0.920.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Competitive inhibitor of spermine and spermidine synthases.
Product Specific Literature References
Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors: A. Shirahata, et al.; Biochem. Pharmacol. 41, 205 (1991) Abstract
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo: P.J. Chu, et al.; Eur. J. Pharmacol. 256, 155 (1994) Abstract
 
 
ALX-270-125 Revised 25-Apr-08
Resveratrol
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SYNONYMS trans-3,4’,5-Trihydroxystilbene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-125-M050   50 mg 36.00 USD Add To Cart
ALX-270-125-M100   100 mg 50.00 USD Add To Cart
ALX-270-125-M250   250 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C14H12O3
MW: 228.2
CAS NUMBER: 501-36-0
MERCK INDEX: 14: 8158
SOURCE/HOST: Isolated from Polygonum cuspidatum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: ~65mg/ml soluble in DMSO, 100% ethanol or dimethyl formamide; slightly soluble in PBS, pH 7.2 (~100 µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. Antioxidant. Potent activator of human deacetylase SIRT1. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis.
Product Specific Literature References
Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996) Abstract
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) Abstract
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004) Abstract
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004) Abstract
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006) Abstract
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) Abstract
Related Products
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Stilbenoids • Sirtuins / Related Products • COX Inhibitors
 
 
ALX-270-126 Revised 13-Dec-04
Trequinsin . hydrochloride
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SYNONYMS 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl
HL 725 . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-126-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C24H27N3O3 . HCl
MW: 405.5 . 36.5
CAS NUMBER: 79855-88-2
PURITY: ≥98%
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from moisture.

Product Description
Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll) in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Product Specific Literature References
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982) Abstract
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990) Abstract
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990) Abstract; Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991) Abstract
 
 
ALX-270-127 Revised 07-Dec-04