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TLR Antibodies
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ALX-210-853 Revised 12-Apr-06
Polyclonal Antibody to Toll-like Receptor 5 (human)
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SYNONYMS anti-TLR5 (human) PAb
anti-Toll/Interleukin-1 Receptor-like Gene 3 (human) PAb
anti-TIL3 (human) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-853-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 151-181 (D151LSKNQIRSLYL
HPSFGKLNSLKSIDFSSNQ181) of human TLR5 (Toll-like receptor 5).
SPECIFICITY: Recognizes human TLR5.
APPLICATION: Flow Cytometry
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250))
Western Blot
QUALITY CONTROL: Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-168-012.
General Information

Note: Human Toll-like Receptor 5 (TLR5) is also described as Toll/Interleukin-1 Receptor-like Gene 3 (TIL3).
General Literature References
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans: P.M. Chaudhary, et al.; Blood 91, 4020 (1998) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-873 Revised 02-Jun-08
Polyclonal Antibody to Toll-like Receptor 6
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SYNONYMS anti-TLR6 PAb
anti-CD286 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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ALX-210-873-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to a portion of mouse TLR6 (Toll-like receptor 6).
SPECIFICITY: Recognizes human and mouse TLR6. Detects a band of ~92kDa by Western blot.
APPLICATION: Flow Cytometry (2µg/106 cells)
Western blot (1-2µg/ml).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
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Product Specific Literature References
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract: M.A. Palladino, et al; Biol. Reprod. 76, 958 (2007) Abstract
General Information
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The aa sequence of human TLR6 is most similar to hTLR1 with 69% identity at the aa level. Human TLR6 consists of a predicted 807 aa with a molecular weight of approximately 92 kDa. Human and mouse TLR6 share an aa identity of 73%. TLR6 activates both NF-κB and c-Jun N-terminal Kinase (JNK). The aa in the cytoplasmic domain of IL-1 receptor, which are critical for NF-κB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6. TLR6 is predominantly expressed in spleen, thymus, ovary, and lung.
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-874 Revised 13-May-08
Polyclonal Antibody to Toll-like Receptor 7
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SYNONYMS anti-TLR7 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-874-C100   100 µg 293.00 USD Add To Cart
ALX-210-874PF-C100 Preservative Free 100 µg 319.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: ALX-210-874: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
ALX-210-874PF: Liquid. In PBS.
IMMUNOGEN: Synthetic peptide corresponding to aa 706-728 of human TLR7 (Toll-like receptor 7).
SPECIFICITY: Recognizes human and mouse TLR7.
APPLICATION: Immunocytochemistry (see [1])
Flow Cytometry (intracellular (2-5µg/106 cells), cell surface (see [5]))
Immunohistochemistry (frozen sections (see [4]), paraffin sections (5-10µg/ml))
Immunoprecipitation (see [8])
Western Blot (1-3µg/ml; in human Ramos cells, additional bands are seen)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
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Product Specific Literature References
[1] Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line: M.D. Srivastava and B.I. Srivastava; Leuk. Res. 29, 813 (2005) Abstract
[2] Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad: S. Francois, et al.; J. Immunol. 174, 3633 (2005) Abstract
[3] TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production: O.M. Hart, et al.; J. Immunol. 175, 1636 (2005) Abstract
[4] Toll-like receptor-7 modulates immune complex glomerulonephritis: R.D. Pawar, et al.; J. Am. Soc. Nephrol. 17, 141 (2006) Abstract; Full Text
[5] Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice: P.S. Patole, et al.; Nephrol. Dial. Transplant. 21, 3062 (2006) Abstract
[6] Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract: M.A. Palladino, et al.; Biol. Reprod. 76, 958 (2007) Abstract
[7] Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder: E.B. Smith, et al.; J. Urol. 177, 2347 (2007) Abstract
[8] The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling: M.M. Brinkmann, et al.; J. Cell Biol. 177, 265 (2007) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-639 Revised 16-Oct-07
Polyclonal Antibody to Toll-like Receptor 8
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SYNONYMS anti-TLR8 PAb
anti-CD288 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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ALX-210-639-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 81-109 (CE81SFQGLQNLTKINLNHNPNVQHQNGNPGI109) of the N-terminal domain of human TLR8 (Toll-like receptor 8).
SPECIFICITY: Recognizes human and mouse TLR8.
APPLICATION: Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-168-015.
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Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-368 Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 9
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SYNONYMS anti-TLR9 PAb
anti-CD289 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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ALX-210-368-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 275-291 of mouse TLR9 (Toll-like receptor 9) (extracellular domain).
SPECIFICITY: Recognizes human and mouse TLR9. Detects a band of ~113kDa by Western blot.
APPLICATION: Flow Cytometry (intracellular (1-2µg/106))
Flow Cytometry (cell surface (see [6]))
Immunocytochemistry (see [5])
Immunocytochemistry (paraffin sections (see [8]); frozen sections (10µg/ml) (see [6]))
Western Blot (0.5-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
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Product Specific Literature References
[1] Toll-like receptor 9 regulates tumor necrosis factor-alpha expression by different mechanisms. Implications for osteoclastogenesis: A. Amcheslavsky, et al.; J. Biol. Chem. 279, 54039 (2004) Abstract; Full Text
[2] IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA: M. Uchijima, et al.; Immunol. Cell Biol. 83, 92 (2005) Abstract
[3] Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects: I.N. Buhtoiarov, et al.; J. Immunol. 176, 309 (2006) Abstract; Full Text
[4] Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide: L. Chen, et al.; J. Immunol. 177, 2373 (2006) Abstract; Full Text
[5] Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity: M.A. Merrell, et al.; Mol. Cancer Res. 4, 437 (2006) Abstract; Full Text
[6] Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice: P.S. Patole, et al.; Nephrol. Dial. Transplant. 21, 3062 (2006) Abstract
[7] Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro: J.M. Ilvesaro, et al.; Prostate 67, 774 (2007) Abstract
[8] Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation: N. Tran, et al.; ; J. Clin. Endocrinol. Metab. 92, 2773 (2007) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-642 Revised 12-Oct-07
Polyclonal Antibody to Toll-like Receptor 9 (human)
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SYNONYMS anti-TLR9 (human) PAb
anti-CD289 (human) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-642-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 205-233 (CS205LKYNNLTVVPRNLPSSLEYLLLSYNRIVKL235) of the N-terminal domain of human TLR9 (Toll-like receptor 9).
SPECIFICITY: Recognizes human TLR9. Cross-reacts with mouse TLR9.
APPLICATION: Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-168-016.
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Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-637 Revised 12-Oct-07
Polyclonal Antibody to Toll-like Receptor 9 (mouse)
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SYNONYMS anti-TLR9 (mouse) PAb
anti-CD289 (mouse) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-637-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 204-224 (L204SLKYNNLTKVPRQLPPSLEY224C) of the N-terminal domain of mouse TLR9 (Toll-like receptor 9).
SPECIFICITY: Recognizes mouse TLR9. Cross-reacts with human TLR9.
APPLICATION: Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-168-013.
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Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-643 Revised 23-Oct-07
Polyclonal Antibody to Toll-like Receptor 10 (human)
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SYNONYMS anti-TLR10 (human) PAb
anti-CD290 (human) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-643-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope affinity-purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 81-111 (CH81NRIQQLDLKTFEFNKELRYLDLSNNRLKSV111) of human TLR10 (Toll-like receptor 10).
SPECIFICITY: Recognizes human TLR10.
APPLICATION: Immunocytochemistry (acetone fixed cells (1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot  (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-168-017.
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Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-215-014 Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 10 (mouse/rat)
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SYNONYMS anti-TLR10 (mouse/rat) PAb
anti-CD290 (mouse/rat) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-014-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Mixture of 3 synthetic peptides corresponding to aa 37-52 (M37SLRKVPADLTPATTT52), aa 235-251 (R235NLSLENAKTSVLLLNK251) and aa 393-409 (F393ANNTPLEHLDLSQNLL409) of human TLR10 (Toll-like receptor 10).
SPECIFICITY: Recognizes mouse and rat TLR10. By ELISA strongly detects aa 37-52, weakly detects aa 235-251 and 392-409. For detection of human TLR10 use MAb to Toll-like Receptor 10 (human) (158C1114) (Prod. No. ALX-804-407).
APPLICATION: ELISA (1:100-1’000)
Western Blot (5µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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Related Products
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-215-013 Revised 01-Nov-07
Polyclonal Antibody to Toll-like Receptor 11 (mouse)
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SYNONYMS anti-TLR11 (mouse) PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-013-C100   100 µg 293.00 USD