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ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-085
Revised 05-Sep-07
Adenosine-3’,5’-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-cAMPS . Na
cAMPS . Na, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-085-M001
1 mg
120.00 USD
ALX-480-085-M005
5 mg
490.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
73208-40-9
PURITY:
≥99% (low adenosine, cAMP and Sp-cAMPS content)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-012
).
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-012
Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
SYNONYMS
Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-012-M001
1 mg
110.00 USD
ALX-480-012-M005
5 mg
460.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
5
PS . C
6
H
16
N
MW:
345.5 . 101.0
CAS NUMBER:
151837-09-1
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase:
J.D. Rothermel; Biochem. J.
251
, 757 (1988)
Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates:
E. Butt, et al.; FEBS Lett.
263
, 47 (1990)
Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
:
L.Y. Wang, et al.; Science
253
, 1132 (1991)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-086
Revised 30-Aug-06
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-cAMPS . Na
cAMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-086-M001
1 mg
75.00 USD
ALX-480-086-M005
5 mg
300.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
717794-13-5
PURITY:
≥99% (low adenosine, cAMP and Rp-cAMPS content)
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-013
).
Further Categories Containing This Product:
PKA Activators
ALX-480-013
Revised 10-Feb-05
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . triethylammonium salt
SYNONYMS
Sp-cAMPS . TEA
cAMPS . TEA, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-013-M001
1 mg
75.00 USD
ALX-480-013-M005
5 mg
298.00 USD
ALX-480-013-M010
10 mg
580.00 USD
Product Specification
FORMULA:
C
16
H
27
N
6
O
5
PS
MW:
446.5
CAS NUMBER:
93602-66-5
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Considerably higher resistance against cyclic nucleotide-dependent phosphodiesterases as compared to N
6
,O
2'
-dibutyryladenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP) (Prod. No.
ALX-480-045
) or 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) (Prod. No.
ALX-480-007
). No metabolic side effects. Membrane permeable in many biological systems.
Product Specific Literature References
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin- permeabilized parotid acini:
T. Takuma & T. Ichida; J. Biochem.
110
, 292 (1991)
Abstract
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange:
T. Sugimoto, et al.; J. Cell Physiol.
152
, 28 (1992)
Abstract
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone:
H. Kaji, et al.; BBRC
182
, 1356 (1992)
Abstract
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging:
P.J. Sammak, et al.; J. Cell. Biol.
117
, 57 (1992)
Abstract
Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction:
W. Van Der Kloot & D.D. Branisteanu; Pfluegers Arch.
420
, 336 (1992)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-001
Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
SYNONYMS
ADP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-001-G001
1 g
45.00 USD
ALX-480-001-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
10
P
2
. 2Na
MW:
471.2 . 46.0
CAS NUMBER:
16178-48-6
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥
95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
SYNONYMS
ADP . K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-002-G001
1 g
45.00 USD
ALX-480-002-G005
5 g
180.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
10
P
2
. K
MW:
426.2 . 39.1
CAS NUMBER:
72696-48-1
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during prolonged storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-014
Revised 25-Oct-06
Adenosine 5'-monophosphate . disodium salt
SYNONYMS
AMP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-014-G005
5 g
68.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
7
P . 2Na
MW:
345.2 . 46.0
CAS NUMBER:
4578-31-8
MERCK INDEX:
14:
158
RTECS:
AU7481600
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water and aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
ALX-480-017
Revised 24-Nov-04
Adenosine 5'-O-thiomonophosphate . dilithium salt
SYNONYMS
5'-AMPS . 2 Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-017-M001
1 mg
15.00 USD
ALX-480-017-M005
5 mg
45.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
6
PS . 2Li
MW:
361.3 . 13.9
CAS NUMBER:
93839-85-1
PURITY:
≥97%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Product Description
Substrate and inhibitor of AMP-dependent enzyme systems.
Product Specific Literature References
Adenosine 5'-phosphorothioate. A nucleotide analog that is a substrate, competitive inhibitor, or regulator of some enzymes that interact with adenosine 5'-phosphate
:
A.W. Murray & M.R. Atkinson; Biochemistry
7
, 4023 (1968)
Abstract
ALX-480-066
Revised 22-Oct-08
Adenosine 5'-O-(3-thiotriphosphate) . tetralithium salt
SYNONYMS
ATP-γS . 4Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-066-M001
1 mg
25.00 USD
ALX-480-066-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
12
P
3
S . 4Li
MW:
520.2 . 27.8
CAS NUMBER:
93889-89-5
PURITY:
≥90%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
HANDLING:
Protect from moisture.
HAZARD:
IRRITANT.
Product Description
ATP analog that can substitute ATP in various kinase reactions. Substrate and inhibitor of ATP-dependent enzyme systems. The resulting thiophosphorylated proteins are resistant to dephosphorylation by protein phosphatases. Increases the activity of Ca
2+
-activated K
+
channels.
Product Specific Literature References
The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate)
:
S. Chrysogelos, et al.; J. Biol. Chem.
258
, 12624 (1983)
Abstract
;
Full Text
Regulation of phosphoinositide breakdown by guanine nucleotides:
I. Litosch & J.N. Fain; Life Sci.
39
, 187 (1986)
Abstract
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation:
J. Chen, et al.; Science
257
, 1261 (1992)
Abstract
Further Categories Containing This Product:
K+ Channel Activators
ALX-480-021
Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
SYNONYMS
ATP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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