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ALX-165-007
Revised 05-Dec-04
Phospholipase A2 Activating Peptide
SYNONYMS
PLAP
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Activators
Ordering Information
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Format:
Size:
Unit Price:
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ALX-165-007-MC01
0.1 mg
40.00 USD
ALX-165-007-M001
1 mg
140.00 USD
Product Specification
SEQUENCE:
H-Glu-Ser-Pro-Leu-Ile-Ala-Lys-Val-Leu-Thr-Thr-Glu-Pro-Pro-Ile-Ile-Thr-Pro-Val-Arg-Arg-OH
FORMULA:
C
106
H
184
N
28
O
30
MW:
2330.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide fragment from phospholipase A
2
(PLA
2
)
activating protein (PLAP) that activates phospholipase A
2
in a dose-dependent manner. The amino acid sequence bears considerable homology to melittin.
Product Specific Literature References
Cloning of a phospholipase A2-activating protein:
M.A. Clark, et al.; PNAS
88
, 5418 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-024
Revised 06-Feb-05
PKI-tide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
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Format:
Size:
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ALX-165-024-M001
1 mg
75.00 USD
ALX-165-024-M005
5 mg
290.00 USD
Product Specification
SEQUENCE:
H-Ile-Ala-Ala-Gly-Arg-Thr-Gly-Arg-Arg-Gln-Ala-Ile-His-Asp-Ile-Leu-Val-Ala-Ala-OH
FORMULA:
C
85
H
149
N
31
O
24
MW:
1989.3
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific inhibitor of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide:
Y. Hashimoto & T.R. Soderling; Arch. Biochem. Biophys.
252
, 418 (1987)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-022
Revised 04-Mar-05
pp60c-src (521-533) (phosphorylated)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-165-022-MC05
0.5 mg
50.00 USD
ALX-165-022-M001
1 mg
80.00 USD
ALX-165-022-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO
3
H
2
)-Gln-Pro-Gly-Glu-Asn-Leu-OH
FORMULA:
C
62
H
95
N
16
O
28
P
MW:
1543.5
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
This peptide is derived from the C-terminal region of the c-Src protooncogene pp60
c-src
and binds intramolecularly or intermolecularly to the SH2 domain of the same protein.
Product Specific Literature References
Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]:
L.C. Cantley, et al.; Cell
64
, 281 (1991), (Review)
Abstract
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src:
R.R. Roussel, et al.; PNAS
88
, 10696 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
Tyrosine Kinase Inhibitors
ALX-165-004
Revised 07-Feb-05
pp60v-src (137-157)
SYNONYMS
Peptide A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
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ALX-165-004-MC01
0.1 mg
40.00 USD
ALX-165-004-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Val-Ala-Pro-Ser-Asp-Ser-Ile-Gln-Ala-Glu-Glu-Trp-Tyr-Phe-Gly-Lys-Ile-Thr-Arg-Arg-Glu-OH
FORMULA:
C
111
H
168
N
30
O
35
MW:
2482.7
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of Src and EGF receptor tyrosine kinases. The peptide sequence corresponds to residues 137-157 of the noncatalytic domain of the transforming protein of
Rous sarcoma
virus (pp60
v-scr
).
Product Specific Literature References
A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases:
K. Sato, et al.; BBRC
171
, 1152 (1990)
Abstract
Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site:
Y. Fukami, et al.; J. Biol. Chem.
268
, 1132 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
•
Tyrosine Kinase Inhibitors
ALX-165-023
Revised 07-Feb-05
pp60v-src Fragment
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
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ALX-165-023-M001
1 mg
70.00 USD
ALX-165-023-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gly-OH
FORMULA:
C
66
H
109
N
23
O
23
MW:
1592.7
CAS NUMBER:
81493-98-3
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Protein tyrosine kinase substrate. Residues 2-12 in this peptide correspond to the sequence of the reported site of tyrosine phosphorylation (i.e. aa 412-422) in the
Rous sarcoma
virus (RSV)-encoded transforming protein pp60
v-src
.
In vitro
tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes:
L.J. Pike, et al.; PNAS
79
, 1443 (1982)
Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function:
L.J. Pike, et al.; J. Biol. Chem.
261
, 3782 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-165-009
Revised 20-Nov-06
Protein Kinase C (19-31)
SYNONYMS
PKC (19-31)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
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ALX-165-009-M001
1 mg
50.00 USD
ALX-165-009-M005
5 mg
200.00 USD
Product Specification
SEQUENCE:
H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH
FORMULA:
C
67
H
118
N
26
O
16
MW:
1543.8
SOURCE/HOST:
Synthetic.
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Pseudosubstrate prototope of the PKC regulatory domain. Inhibitor of protein kinase C (PKC).
Product Specific Literature References
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain:
C. House & B.E. Kemp; Science
238
, 1726 (1987)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-017
Revised 20-Nov-06
[Ser25]-Protein Kinase C (19-31)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
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Format:
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ALX-165-017-M001
1 mg
60.00 USD
ALX-165-017-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val-OH
FORMULA:
C
67
H
118
N
26
O
17
MW:
1559.8
CAS NUMBER:
136795-05-6
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Pseudosubstrate prototope of the PKC regulatory domain. High affinity substrate for protein kinase C (PKC).
Product Specific Literature References
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain:
C. House & B.E. Kemp; Science
238
, 1726 (1987)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-010
Revised 20-Nov-06
Protein Kinase C (19-36)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-165-010-M001
1 mg
110.00 USD
ALX-165-010-M005
5 mg
440.00 USD
Product Specification
SEQUENCE:
H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn-OH
FORMULA:
C
93
H
159
N
35
O
24
MW:
2151.5
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Pseudosubstrate prototope of the protein kinase C (PKC) regulatory domain. Specifically inhibits both autophosphorylation and protein substrate phosphorylation. Does not inhibit cAMP-dependent protein kinase (PKA). Longer sequence and less potent inhibitor than Prod. No.
ALX-165-009
.
Product Specific Literature References
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain:
C. House & B.E. Kemp; Science
238
, 1726 (1987)
Abstract
A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes:
D.R. Alexander, et al.; Biochem. J.
260
, 893 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-011
Revised 20-Nov-06
Protein Kinase C (530-558)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Activators
Ordering Information
Product Numbers:
Format:
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ALX-165-011-MC01
0.1 mg
130.00 USD
Product Specification
SEQUENCE:
H-Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-NH
2
FORMULA:
C
148
H
221
N
35
O
50
S
2
MW:
3354.7
CAS NUMBER:
122613-29-0
SOURCE/HOST:
Synthetic.
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in 0.05M sodium bicarbonate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activates protein kinase C (PKC), presumably by binding to the pseudosubstrate sequence.
Product Specific Literature References
A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C:
C. House, et al.; FEBS Lett.
249
, 243 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-013
Revised 20-Nov-06
Protein Kinase C Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
Product Numbers:
Format:
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ALX-165-013-M001
1 mg
35.00 USD
ALX-165-013-M005
5 mg
140.00 USD
Product Specification
SEQUENCE:
H-Val-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA:
C
51
H
100
N
22
O
11
MW:
1197.5
CAS NUMBER:
105802-82-2
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
APPEARANCE:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Detection of nerve growth factor and epidermal growth factor-regulated protein kinases in PC12 cells with synthetic peptide substrates:
L.E. Heasley & G.L. Johnson; Mol. Pharmacol.
35
, 331 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-018
Revised 09-Dec-04
Protein Kinase p34cdc2 Substrate
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDKs & Cyclins Other Products
Ordering Information
Product Numbers:
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ALX-165-018-M001
1 mg
130.00 USD
Product Specification
SEQUENCE:
H-Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe-OH
FORMULA:
C
106
H
172
N
32
O
32
MW:
2406.7
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly specific substrate for p34
cdc2
protein kinase, an enzyme involved in mitosis and onset of the S phase.
Product Specific Literature References
Characterization of synthetic peptide substrates for p34cdc2 protein kinase:
D.R. Marshak, et al.; J. Cell. Biochem.
45
, 391 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-028
Revised 23-Nov-06
Protein Tyrosine Kinase pp60c-src Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
U
