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Signal Transduction
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 Items 180-200 of 2953 Page 10 of 148 Select Page: << 6 7 8 9 10 11 12 13 14 15  >>  
ALX-270-210 Revised 06-Feb-05
NS-2028
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SYNONYMS 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-210-M001   1 mg 30.00 USD Add To Cart
ALX-270-210-M005   5 mg 90.00 USD Add To Cart
ALX-270-210-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C9H5N2O3Br
MW: 269.1
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and selective inhibitor of nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC). Inhibits also the basal, the YC-1 and the coenhanced sGC activity.
Product Specific Literature References
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase: S.P. Olesen, et al.; Br. J. Pharmacol. 123, 299 (1998) Abstract
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production: L. Bang, et al.; Scand. Cardiovasc. J. 33, 33 (1999) Abstract
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase: I. Fleming, et al.; PNAS 96, 1123 (1999) Abstract
 
 
ALX-270-212 Revised 26-Jan-07
Captopril
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SYNONYMS (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-212-G001   1 g 20.00 USD Add To Cart
ALX-270-212-G005   5 g 70.00 USD Add To Cart
Product Specification
FORMULA: C9H15NO3S
MW: 217.3
CAS NUMBER: 62571-86-2
MERCK INDEX: 14: 1774
RTECS: UY0550000
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, chloroform, dichloromethane or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE TERATOGENIC. HARMFUL.

Product Description
First orally active angiotensin-converting enzyme (ACE) inhibitor. Reversible and competitive inhibitor of LTA4 hydrolase. Inhibits angiogenesis. Antihypotensive agent.
 
 
ALX-270-213 Revised 13-Dec-06
S-Nitrosocaptopril
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-213-M010   10 mg 60.00 USD Add To Cart
ALX-270-213-M050   50 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H14N2O4S
MW: 246.3
PURITY: ≥98%
APPEARANCE: Red crystals.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Angiotensin-converting enzyme (ACE) inhibitor. Inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, yielding nitric oxide (NO) and the parent compound, captopril (Prod. No. ALX-270-212).
Product Specific Literature References
S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets: J. Loscalzo, et al.; J. Pharmacol. Exp. Ther. 249, 726 (1989) Abstract
S-nitrosocaptopril. II. Effects on vascular reactivity: J.P. Cooke, et al.; J. Pharmacol. Exp. Ther. 249, 730 (1989) Abstract
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther. 256, 704 (1991) Abstract
Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier: J.W. Park; BBRC 189, 206 (1992) Abstract
Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide: M. Amano, et al.; J. Cardiovasc. Pharmacol. 24, 860 (1994) Abstract
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin: T. Matsumoto, et al.; J. Pharmacol. Exp. Ther. 275, 1247 (1995) Abstract
The effects of S-nitrosocaptopril on canine coronary circulation: I. Nakae, et al.; J. Pharmacol. Exp. Ther. 274, 40 (1995) Abstract
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats: L. Jia & R.C. Blantz; Eur. J. Pharmacol. 354, 33 (1998) Abstract
Physicochemistry, pharmacokinetics, and pharmacodynamics of S-nitrosocaptopril crystals, a new nitric oxide donor: L. Jia, et al.; J. Pharm. Sci. 88, 981 (1999) Abstract
Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor: L. Jia, et al.; Eur. J. Pharmacol. 391, 137 (2000) Abstract
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S-nitrosylated captopril, a nitric oxide donor: L. Jia & H. Wong; Br. J. Pharmacol. 134, 1697 (2001) Abstract
S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats: D.Y. Tsui, et al.; Br. J. Pharmacol. 138, 855 (2003) Abstract
S-nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats: D.Y. Tsui, et al.; J. Pharm. Pharmacol. 55, 1121 (2003) Abstract
Further Categories Containing This Product:
Nitric Oxide Donors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-270-215 Revised 15-Apr-05
Tyrphostin AG 1517
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SYNONYMS PD 153,035
SU 5271
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-215-M005   5 mg 85.00 USD Add To Cart
ALX-270-215-M025   25 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C16H14BrN3O2
MW: 360.2
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Further Categories Containing This Product:
EGFR Kinase Inhibitors
 
 
ALX-270-217 Revised 03-Sep-08
Tyrphostin AG 1024
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-217-M001   1 mg 65.00 USD Add To Cart
ALX-270-217-M005   5 mg 250.00 USD Add To Cart
Product Specification
FORMULA: C14H13BrN2O
MW: 305.2
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in acetonitrile (5mg/ml), DMSO (50mg/ml), dichloromethane or methanol (5mg/ml); insoluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
MELTINGPOINT: 185°C (lit.)

Product Description
Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.
Product Specific Literature References
The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry 32, 4650 (1993) Abstract
Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins: M. Parrizas, et al.; Endocrinology 138, 1427 (1997) Abstract; Full Text
Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells: A. Camirand & M. Pollak; Br. J. Cancer 90, 1825 (2004) Abstract
 
 
ALX-270-219 Revised 15-May-07
BAY 11-7082
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SYNONYMS (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-219-M010   10 mg 45.00 USD Add To Cart
ALX-270-219-M050   50 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C10H9NO2S
MW: 207.3
CAS NUMBER: 195462-67-7
PURITY: ≥99%
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.
Product Specific Literature References
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) Abstract; Full Text
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells: S.A. Keller, et al.; Blood 96, 2537 (2000) Abstract
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways: M.M. Remacle-Bonnet, et al.; Cancer Res. 60, 2007 (2000) Abstract
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem. 275, 1887 (2000) Abstract; Full Text
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001) Abstract
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death: T.M. Kauppinen & R.A. Swanson; J. Immunol. 174, 2288 (2005) Abstract; Full Text
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
 
 
ALX-270-220 Revised 04-Nov-05
BAY 11-7085
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SYNONYMS (E)-3-(t-Butylphenylsulfonyl)-2-propenenitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-220-M010   10 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H15NO2S
MW: 249.3
CAS NUMBER: 196309-76-9
PURITY: ≥98%
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO or ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Has biological properties very similar to those of BAY 11-7082 (Prod. No. ALX-270-219). In addition, the product exhibits potent anti-inflammatory properties in vivo.
Product Specific Literature References
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) Abstract; Full Text
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis: U. Koedel, et al.; J. Infect Dis. 182, 1437 (2000) Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001) Abstract
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
 
 
ALX-270-222 Revised 13-Jun-03
Tyrphostin AG 30
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SYNONYMS Tyrphostin A36
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-222-M005   5 mg 65.00 USD Add To Cart
ALX-270-222-M010   10 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C10H7NO4
MW: 205.2
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or acetone; insoluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

 
 
ALX-270-223 Revised 11-Dec-04
Tyrphostin AG 114
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SYNONYMS Tyrphostin A50
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-223-M005   5 mg 65.00 USD Add To Cart
ALX-270-223-M010   10 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C13H8N4O2
MW: 252.2
PURITY: ≥98%
APPEARANCE: Orange to brown solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

 
 
ALX-270-224 Revised 13-Jun-03
Tyrphostin AG 34
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SYNONYMS Tyrphostin A24
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-224-M001   1 mg 35.00 USD Add To Cart
ALX-270-224-M005   5 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C11H8N2O3
MW: 216.2
PURITY: ≥98%
APPEARANCE: Orange to brown solid.
SOLUBILITY: Soluble in DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

 
 
ALX-270-225 Revised 28-Mar-08
Tyrphostin AG 957
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-225-M001   1 mg 35.00 USD Add To Cart
ALX-270-225-M005   5 mg 100.00 USD