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Items 17 of 17
ALX-350-089
Revised 13-May-08
Croton oil
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
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ALX-350-089-KI45
4.5 kg
2'400.00 USD
Product Specification
CAS NUMBER:
8001-28-3
MERCK INDEX:
14:
2598
RTECS:
GQ6300000
APPEARANCE:
Pale-yellow to brown-yellow oil.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. TOXIC.
Product Description
Natural source of phorbol and phorbol esters, purified from
Croton
tiglium L.
ALX-445-009
Revised 21-Aug-08
12-Deoxyphorbol 13-acetate
SYNONYMS
Prostratin
13-Acetyl-12-deoxyphorbol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
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ALX-445-009-M001
1 mg
80.00 USD
ALX-445-009-M005
5 mg
320.00 USD
Product Specification
FORMULA:
C
22
H
30
O
6
MW:
390.5
CAS NUMBER:
60857-08-1
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE CARCINOGENIC. IRRITANT.
Product Description
Protein kinase C (PKC) activator that does not induce tumor formation. Upregulates latent HIV-1 provirus expression and inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle.
Product Specific Literature References
The structure of prostratin: A toxic tetracyclic diterpene ester from Pimelea prostrata.:
A.R. Cashmore, et al.; Tetrahedron Lett.
20
, 1737 (1976)
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex:
S. Zayed, et al.; Experientia
33
, 1554 (1977)
Abstract
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin:
Z. Szallasi, et al.; Cancer Res.
53
, 2507 (1993)
Abstract
Prostratin antagonizes HIV latency by activating NF-kappaB:
S.A. Williams, et al.; J. Biol. Chem.
279
, 42008 (2004)
Abstract
Prostratin as a new therapeutic agent targeting HIV viral reservoirs:
M. Hezareh; Drug News Perspect.
18
, 496 (2005), (Review)
Abstract
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells:
T. L. Sung & A. P. Rice; Retrovirology
3
, 66 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents
•
HIV / AIDS / Related Products
ALX-445-049
Revised 24-Oct-07
12-Deoxyphorbol 13-phenylacetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-049-M005
5 mg
220.00 USD
Product Specification
FORMULA:
C
28
H
34
O
6
MW:
466.6
CAS NUMBER:
58821-98-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO and ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
POTENTIAL TUMOR PROMOTER. IRRITANT.
Product Description
Metabolite of 12-deoxyphorbol 13-phenylacetate 20-acetate. Potent activator of protein kinase C (PKC). Induces the expression of HIV-1 in latently infected T cells.
Product Specific Literature References
Role of protein kinase C isozymes in activation of human immunodeficiency virus type 1 in chronically infected promonocytic cells: evidence against a role of PKC beta 1:
C.H. Kim, et al.; Biochem. Biophys. Res. Commun.
199
, 292 (1994)
Abstract
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes:
Z. Szallasi, et al.; Mol. Pharmacol.
47
, 258 (1995)
Abstract
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate:
S. Bocklandt, et al.; Antiviral Res.
59
, 89 (2003)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-020
Revised 10-Jun-03
20-Oxo-20-deoxyphorbol 12,13-dibutyrate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-020-M001
1 mg
75.00 USD
ALX-445-020-M005
5 mg
330.00 USD
Product Specification
FORMULA:
C
28
H
38
O
8
MW:
502.6
CAS NUMBER:
100930-03-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. POTENTIAL TUMOR PROMOTER.
Product Description
Used to prepare [
3
H]-PDBu.
Product Specific Literature References
Active principles of croton oil. X. Preparation of tritium labeled croton oil factor A1 and other tritium labeled phorbol derivatives
:
G. Kreibich & E. Hecker; Z. Krebsforsch.
74
, 448 (1970)
Abstract
ALX-550-371
Revised 30-Jun-08
PDDHV
SYNONYMS
Phorbol 12,13-didecanoate 20-homovanillate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-550-371-M001
1 mg
50.00 USD
ALX-550-371-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
49
H
72
O
11
MW:
837.1
CAS NUMBER:
179469-40-0
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC. IRRITANT.
Product Description
Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1 (K
i
=60nM). Tumor promotor.
Product Specific Literature References
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1:
A. Szallasi, et al.; Br. J. Pharmacol.
128
, 428 (1999)
Abstract
Further Categories Containing This Product:
Resiniferatoxin-type Phorboid Vanilloids
•
Natural Products for Neurological Research
ALX-550-372
Revised 29-Oct-07
PDNHV
SYNONYMS
Phorbol 12,13-dinonanoate 20-homovanillate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-550-372-M001
1 mg
50.00 USD
ALX-550-372-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
47
H
68
O
11
MW:
809.0
CAS NUMBER:
251362-87-5
PURITY:
≥95%
APPEARANCE:
Clear oil.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, chloroform or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TUMOR PROMOTER. IRRITANT.
Product Description
Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1.
Product Specific Literature References
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1:
A. Szallasi, et al.; Br. J. Pharmacol.
128
, 428 (1999)
Abstract
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism:
A. Macho, et al.; Chem. Biol.
7
, 483 (2000)
Abstract
Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1:
T. Ohta, et al.; Biochem. Pharmacol.
71
, 173 (2005)
Abstract
Further Categories Containing This Product:
Resiniferatoxin-type Phorboid Vanilloids
•
Natural Products for Neurological Research
ALX-445-028
Revised 08-Apr-08
Phorbol 13-acetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-028-M001
1 mg
40.00 USD
ALX-445-028-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
22
H
30
O
7
MW:
406.5
CAS NUMBER:
32752-29-7
RTECS:
QH4377000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE CARCINOGENIC.
Product Description
Reference compound for studying 12-deacylation of phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-003
Revised 08-Apr-08
Phorbol 12,13-diacetate
SYNONYMS
PDA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-003-M001
1 mg
20.00 USD
ALX-445-003-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
24
H
32
O
8
MW:
448.5
CAS NUMBER:
24928-15-2
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. TUMOR PROMOTER.
Product Description
Less potent than phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
), but also less hydrophobic.
Product Specific Literature References
Modulation of high-threshold Ca current and spontaneous postsynaptic transient currents by phorbol 12,13-diacetate, 1-(5-isoquinolinesulfonyl)-2-methyl piperazine (H-7), and monosialoganglioside (GM1) in CA1 pyramidal neurons of rat hippocampus in vitro:
N. Agopyan, et al.; Hippocampus
3
, 67 (1993)
Abstract
Effects of phorbol 12,13-diacetate on human isolated bronchus:
B. Sarria, et al.; Eur. J. Pharmacol.
399
, 65 (2000)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-001
Revised 08-Apr-08
Phorbol 12,13-dibutyrate
SYNONYMS
PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
Product Numbers:
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ALX-445-001-M001
1 mg
20.00 USD
ALX-445-001-M005
5 mg
50.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
37558-16-0
RTECS:
EK7767000
PURITY:
≥99%
APPEARANCE:
Off-white to yellowish oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Widely used protein kinase C (PKC) activator. Less potent than phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
), but also less hydrophobic.
Product Specific Literature References
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets:
D.E. MacIntyre, et al.; FEBS Lett.
180
, 160 (1985)
Abstract
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension:
G.E. Bilder, et al.; J. Pharmacol. Exp. Ther.
252
, 526 (1990)
Abstract
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells:
T.L. Yue, et al.; Neurochem. Res.
17
, 997 (1992)
Abstract
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation:
C. Lisbona, et al.; Eur. J. Immunol.
24
, 2746 (1994)
Abstract
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line:
M.S. Johnson, et al.; Mol. Cell. Biochem.
165
, 65 (1996)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-038
Revised 08-Apr-08
4α-Phorbol 12,13-dibutyrate
SYNONYMS
4α-PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-038-M001
1 mg
30.00 USD
ALX-445-038-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
93781-54-5
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Negative control for phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-002
Revised 03-Dec-07
Phorbol 12,13-didecanoate
SYNONYMS
PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
Ordering Information
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Format:
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Unit Price:
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ALX-445-002-M001
1 mg
20.00 USD
ALX-445-002-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
40
H
64
O
