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Natural Products for Neurological Research
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ALX-350-291 Revised 19-Oct-07
Hymenidin
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SYNONYMS 2-Debromooroidin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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ALX-350-291-M001   1 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C11H12BrN5O
MW: 310.2
CAS NUMBER: 107019-95-4
SOURCE/HOST: Isolated from Hymeniacidon sp.
PURITY: ≥95%
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO or 100 % ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC. CYTOTOXIC.

Product Description
Antagonist of serotonergic receptors. Inhibitor of CDK5/p25 (IC50=4µM) and GSK-3β (IC50=12µM). 
Product Specific Literature References
A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp: J. Kobayashi, et al.; Experientia 42, 1176 (1986) Abstract
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000)
Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation: U. Bickmeyer, et al.; Toxicon. 44, 45 (2004) Abstract
Marine compounds for the therapeutic treatment of neurological disorders: D. Alonso, et al.; Expert Opininon on Therapeutic Patents 15, 1377 (2005)
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Natural Products for Neurological Research • Alkaloids • Serotonergics & Serotonin Receptors / Related Products • Marine Natural Products
 
 
ALX-350-097 Revised 16-Jun-08
Hyperforin . dicyclohexylammonium salt (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-097-C500   500 µg 130.00 USD Add To Cart
ALX-350-097-M001   1 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C35H51O4 . C12H24N
MW: 535.8 . 182.3
CAS NUMBER: 11079-53-1 (non-salt form)
SOURCE/HOST: Isolated from St. John's wort (Hypericum perforatum).
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
PURITY DETAIL: Contains <3% adhyperforin.
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light.

Product Description
Major constituent of St. John’s wort, a herbal remedy widely used for the treatment of depression. Inhibits the reuptake of neurotransmitters in synapses. Activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Specifically activates TRPC6 channels. Represents an interesting lead-structure for a new class of antidepressants. Displays several other biological properties of potential pharmacological interest, including antibacterial, anti-inflammational, antitumoral and anti-angiogenic effects. Induces apoptosis in various cancer cells.
Product Specific Literature References
Hyperforin as a possible antidepressant component of hypericum extracts: S.S. Chatterjee, et al.; Life Sci. 63, 499 (1998) Abstract
Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat: S. Chatterjee, et al.; Life Sci. 65, 2395 (1999) Abstract
Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria: C.M. Schempp, et al.; Lancet 353, 2129 (1999) Abstract
Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1: A. Singer, et al.; J. Pharmacol. Exp. Ther. 290, 1363 (1999) Abstract
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor: L.B. Moore, et al.; PNAS 97, 7500 (2000) Abstract
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression: R.S. Obach; J. Pharmacol. Exp. Ther. 294, 88 (2000) Abstract
St John's wort, a herbal antidepressant, activates the steroid X receptor: J.M. Wentworth, et al.; J. Endocrinol. 166, R11 (2000) Abstract
St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties: J. Barnes, et al.; J. Pharm. Pharmacol. 53, 583 (2001), (Review) Abstract
St John's wort: Prozac from the plant kingdom: G. Di Carlo, et al.; TIPS 22, 292 (2001), (Review) Abstract
Effect of St. John's wort on free radical production: E.J. Hunt, et al.; Life Sci. 69, 181 (2001) Abstract
Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology: P.J. Nathan; J. Psychopharmacol. 15, 47 (2001), (Review) Abstract
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem 6, 171 (2005) Abstract
Hyperforin, a new lead compound against the progression of cancer and leukemia?: C. Quiney, et al.; Leukemia 20, 1519 (2006), (Review) Abstract
Hyperforin a key constituent of St. John’s wort specifically activates TRPC6 channels: K. Leuner, et al.; FASEB J. 21, 4101 (2007) Abstract
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Pregnane X Receptor [PXR] / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products for Angiogenesis Research • Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors • Neuroactive Agents Other Products • Natural Products - Antitumor Reagents • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-350-030 Revised 20-Oct-08
Hypericin (native)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-030-M001   1 mg 50.00 USD Add To Cart
ALX-350-030-M005   5 mg 200.00 USD Add To Cart
ALX-350-030-M010   10 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C30H16O8
MW: 504.4
CAS NUMBER: 548-04-9
MERCK INDEX: 14: 4863
SOURCE/HOST: Isolated from Hypericum perforatum.
PURITY: ≥98% (HPLC)
APPEARANCE: Black to black-red powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone, ethylmethylketone, pyridine or other organic solvents and bases.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and oxygen.
HAZARD: MAY BE TERATOGENIC. HARMFUL. MAY BE MUTAGENIC.

Product Description
Inhibitor of protein kinase C (PKC). Shows anti-viral and anti-retroviral activity. Displays antineoplastic and antitumor activities. Inhibits casein kinase II (CKII) and MAP kinase. Bright red fluorescence emission and photostability. Antidepressant.
Product Specific Literature References
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS 85, 5230 (1988) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus: D.L. Barnard, et al.; Antiviral Res. 17, 63 (1992) Abstract
Photosensitized inhibition of growth factor-regulated protein kinases by hypericin: P. Agostinis, et al.; Biochem. Pharmacol. 49, 1615 (1995) Abstract
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C: W. Zhang, et al.; Cancer Lett. 96, 31 (1995) Abstract
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis: A. Vantieghem, et al.; FEBS Lett. 440, 19 (1998) Abstract
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin: Z. Assefa, et al.; J. Biol. Chem. 274, 8788 (1999) Abstract; Full Text
Over-expression of Bcl-2 does not protect cells from hypericin photo- induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway: R. Chaloupka, et al.; FEBS Lett. 462, 295 (1999) Abstract
Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells: K.T. Lee, et al.; Biol. Pharm. Bull. 22, 1271 (1999) Abstract
Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin: P. Agostinis, et al.; Adv. Enzyme Regul. 40, 157 (2000) Abstract
Hypericin--a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules: P. Miskovsky; Curr. Drug Targets 3, 55 (2002), (Review) Abstract
Hypericin--the facts about a controversial agent: A. Kubin, et al.; Curr. Pharm. Des. 11, 233 (2005), (Review) Abstract
Cellular mechanisms and prospective applications of hypericin in photodynamic therapy: T. Kiesslich, et al.; Curr. Med. Chem. 13, 2189 (2006), (Review) Abstract
Further Categories Containing This Product:
Casein Kinase Inhibitors • MAPK Pathway Inhibitors • PKC Inhibitors • Neuroactive Agents Other Products • Natural Products for Neurological Research • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antitumor Reagents
 
 
ALX-550-389 Revised 11-Apr-08
5’-Iodo-resiniferatoxin
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SYNONYMS I-RTX
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-389-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C37H39IO9
MW: 754.6
PURITY: ≥97% (HPLC)
APPEARANCE: White amorphous solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Binds to TRPV1 receptors expressed in HEK 293 cells (Ki=5.8nM) and to native rat TRPV1 receptors (Ki=4.8nM). At least 40-fold more potent than capsazepine (Prod. No. ALX-550-145). Blocks capsaicin-induced currents in oozytes expressing TRPV1 (IC50=3.9nM). Potently blocks pain responses elicited by capsaicin (Prod. No. ALX-550-066) in vivo.
Product Specific Literature References
Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist: P. Wahl, et al.; Mol. Pharmacol. 59, 9 (2001) Abstract; Full Text
Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin: G.R. Seabrook, et al.; J. Pharmacol. Exp. Ther. 303, 1052 (2002) Abstract; Full Text
Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor: M.E. McDonnell, et al.; Bioorg. Med. Chem. Lett. 12, 1189 (2002) Abstract
Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin: M. Rigoni, et al.; Br. J. Pharmacol. 138, 977 (2003) Abstract; Full Text
Participation of the spinal TRPV1 receptors in formalin-evoked pain transduction: a study using a selective TRPV1 antagonist, iodo-resiniferatoxin: Y. Kanai, et al.; J. Pharm. Pharmacol. 58, 489 (2006) Abstract
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Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Resiniferatoxin-type Phorboid Vanilloids
 
 
ALX-350-262 Revised 07-Oct-08
Kuanoniamine C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-262-M001   1 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C21H18N4OS
MW: 374.5
CAS NUMBER: 133401-11-3
SOURCE/HOST: Isolated from the sponge Oceanapia spec.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cytotoxic. Inhibits proliferation of several cell lines. Binds to adenosine receptor subtypes A1 and A2A.
Product Specific Literature References
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp: C. Eder, et al.; J. Nat. Prod. 61, 301 (1998) Abstract
Pyrroloquinoline and pyridoacridine alkaloids from marine sources: Q. Ding, et al.; Curr. Med. Chem. 6, 1 (1999) Abstract
Further Categories Containing This Product:
Alkaloids • Adenosine Receptors / Related Products • Natural Products for Neurological Research • Antitumor Agents (Anti-proliferative) • Marine Natural Products
 
 
ALX-350-225 Revised 29-Sep-08
Limonin
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SYNONYMS Limonoic acid di-δ-lactone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-225-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C26H30O8
MW: 470.5
CAS NUMBER: 1180-71-8
MERCK INDEX: 14: 5494
SOURCE/HOST: Isolated from grapefruit seed.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or glacial acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Bitter principle of citrus fruits. Inhibits chemically induced carcinogenesis. Inhibits HIV-1 replication. Shows antinociceptive effect. Does not possess any inherent antioxidant activity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982)
R.L. Rouseff; J. Agric. Food Chem. 30, 504 (1982)
M.A. Altieri, et al.; Protect. Ecol. 6, 91 (1984)
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
L.K.T. Lam, et al.; ACS Symposium Series 546, 209 (1994)
Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri: H. Matsuda, et al.; Planta Med. 64, 339 (1998) Abstract
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats: T. Tanaka, et al.; Biofactors 13, 213 (2000) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Analgesic / Anti-nociceptive Agents / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-420-023 Revised 07-Mar-07
Lobeline . hydrochloride
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SYNONYMS L-Lobeline . HCl
2-[6-(2-Hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone . HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-420-023-M050   50 mg 17.00 USD Add To Cart
ALX-420-023-M250   250 mg 50.00 USD Add To Cart
ALX-420-023-G001   1 g 155.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO2 . HCl
MW: 337.5 . 36.5
CAS NUMBER: 134-63-4
MERCK INDEX: 14: 5551
RTECS: OJ8490100
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Neuronal nicotinic acetylcholine receptor agonist. Respiratory stimulant.
Further Categories Containing This Product:
Alkaloids • Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-350-352 Revised 06-Mar-08
Magnolol
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SYNONYMS 5,5’-Diallyl-2,2’-biphenyldiol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-352-M005   5 mg 55.00 USD Add To Cart
ALX-350-352-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 528-43-8
MERCK INDEX: 14: 5697
RTECS: DV5105500
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003) Abstract
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products for Neurological Research • NOS Inhibitors (NOS Induction & Enzyme Activity) • Anxiolytic Agents / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products with Antibiotic Activity • Natural Products - Nitric Oxide Pathway Modulators
 
 
ALX-420-042 Revised 18-Jun-08
(-)-Menthol
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SYNONYMS (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-420-042-M025   25 mg 30.00 USD Add To Cart
ALX-420-042-M100   100 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C10H20O