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Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
 
 
ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
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SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-010-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 67604-48-2
MERCK INDEX: 14: 6424
PURITY: ≥95%
APPEARANCE: Light yellow to tan powder.
SOLUBILITY: Soluble in 100% ethanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract
 
 
ALX-350-110 Revised 08-Apr-08
Nidulal
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-110-MC05   0.5 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C15H16O5
MW: 276.3
SOURCE/HOST: Isolated from Nidula candida.
PURITY: ≥95%
APPEARANCE: Lyophilized
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep cool and dry. Protect from light.
HAZARD: TOXIC.

Product Description
Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells selectively activates AP-1 dependent signal transduction in a manner similar to TPA/PMA (Prod. No. ALX-445-004).
Product Specific Literature References
Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida: G. Erkel, et al.; J. Antibiot. 49, 1189 (1996) Abstract
 
 
ALX-350-308 Revised 03-Apr-08
3-O-Acetyl-β-boswellic acid
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SYNONYMS AβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-308-M001   1 mg 45.00 USD Add To Cart
ALX-350-308-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C32H50O4
MW: 498.8
CAS NUMBER: 5968-70-7
SOURCE/HOST: Isolated from Boswellia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-100 times more potent than natural boswellic acid.
Product Specific Literature References
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004) Abstract
Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005) Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005) Abstract
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
 
 
ALX-350-003 Revised 23-May-08
Okadaic acid (high purity)
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SYNONYMS Halochondrine A (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-003-C025   25 µg 60.00 USD Add To Cart
ALX-350-003-C050   50 µg 110.00 USD Add To Cart
ALX-350-003-C100   100 µg 180.00 USD Add To Cart
ALX-350-003-M001   1 mg 990.00 USD Add To Cart
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Product Specification
FORMULA: C44H68O13
MW: 805.0
CAS NUMBER: 78111-17-8
MERCK INDEX: 14: 6819
RTECS: AA8227800
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography.
PURITY: ≥98% (HPLC)
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Use only fresh solutions.
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: MAY BE CARCINOGENIC. HIGHLY IRRITANT. TOXIC.

Product Description
Potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Tumor promoter. Has shown contractile effect on smooth muscle and heart muscle. Significantly increases cyclin B1 expression in adult neurons.
Product Specific Literature References
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate- type tumor promoter: M. Suganuma, et al.; PNAS 85, 1768 (1988) Abstract
Protein phosphatases come of age: P. Cohen & P.T.W. Cohen; J. Biol. Chem. 264, 21435 (1989) Abstract; Full Text
The structure and regulation of protein phosphatases: P. Cohen; Ann. Rev. Biochem. 58, 453 (1989) Abstract
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism: T.A. Haystead, et al.; Nature 337, 78 (1989) Abstract
Okadaic acid: a new probe for the study of cellular regulation: P. Cohen, et al.; TIPS 15, 98 (1990), (Review) Abstract
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C: R. Gopalakrishna, et al.; BBRC 189, 950 (1992) Abstract
Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils: P. Kreienbuehl, et al.; Blood 80, 2911 (1992) Abstract
Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A: M. Nomura, et al.; Biochemistry 31, 11915 (1992) Abstract
Inhibition of apoptosis in human tumour cells by okadaic acid: Q. Song, et al.; J. Cell Physiol. 153, 550 (1992) Abstract
Okadaic acid enhances human T cell activation and phosphorylation of an internal substrate induced by phorbol myristate acetate: Y. Tada, et al.; Immunopharmacol. 24, 17 (1992) Abstract
Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage: Y. Ohoka, et al.; BBRC 197, 916 (1993) Abstract
Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line: B.T. Gjertsen, et al.; J. Cell. Sci. 107, 3363 (1994) Abstract
Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A: K. Kiguchi, et al.; Cell Growth Differentiation 5, 995 (1994) Abstract
Unique features of the okadaic acid activity class of tumor promoters: H. Fujiki & M. Suganuma; J. Cancer Res. Clin. Oncol. 125, 150 (1999), Review Abstract
Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor: A.B. Dounay & C.J. Forsyth; Curr. Med. Chem. 9, 1939 (2002), Review Abstract
Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase: R. Tamaskovic, et al.; J. Biol. Chem. 278, 6710 (2003) Abstract; Full Text
Okadaic acid induced cyclin B1 expression and mitotic catastrophe in rat cortex: B. Chen, et al.; Neurosci. Lett. 406, 178 (2006) Abstract
 
 
ALX-350-010 Revised 02-Apr-08
Okadaic acid . ammonium salt (high purity)
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SYNONYMS Halochondrine A . Na (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . Na (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-010-C025   25 µg 55.00 USD Add To Cart
ALX-350-010-C100   100 µg 145.00 USD Add To Cart
ALX-350-010-M001   1 mg 980.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . NH4
MW: 804.0 . 18.0
CAS NUMBER: 155716-06-6
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography. Salt form generated in aqueous ammonium hydroxide-methanol solution.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC. HIGHLY IRRITANT.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.
 
 
ALX-350-063 Revised 22-Aug-08
Okadaic acid . potassium salt (high purity)
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SYNONYMS Halochondrine A . K (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . K (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-063-C050   50 µg 90.00 USD Add To Cart
ALX-350-063-C100   100 µg 140.00 USD Add To Cart
ALX-350-063-M001   1 mg 990.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . K
MW: 804.0 . 39.1
CAS NUMBER: 155751-72-7
SOURCE/HOST: Isolated from Prorocentrum concavum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: TOXIC. MAY BE CARCINOGENIC. HIGHLY IRRITANT.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.
General Information
BACKGROUND/TECHNICAL INFORMATION Isolated from Prorocentrum concavum by preparative flash, low pressure and high performance liquid chromatography. Salt form generated in aqueous potassium hydroxide - methanol solution.
 
 
ALX-350-011 Revised 10-Apr-08
Okadaic acid . sodium salt (high purity)
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SYNONYMS Halochondrine A . sodium salt (high purity)
9,10-Deepithio-9,10-didehydroacanthifolicin . sodium salt (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Okadaic Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-011-C025   25 µg 58.00 USD Add To Cart
ALX-350-011-C100   100 µg 160.00 USD Add To Cart
ALX-350-011-M001   1 mg 980.00 USD Add To Cart
Product Specification
FORMULA: C44H67O13 . Na
MW: 804.0 . 23.0
CAS NUMBER: 209266-80-8
SOURCE/HOST: Isolated from Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography. Salt form generated in aqueous sodium hydroxide-methanol solution.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (1mg/ml), 100% ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water. 
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HIGHLY IRRITANT. MAY BE CARCINOGENIC. TOXIC.

Product Description
Salt form of okadaic acid (Prod. No. ALX-350-003), with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Potent tumor promotor and neurotoxin.