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ALX-101-004

Revised 03-Aug-07

L-Arginine
SYNONYMS	H-L-Arg-OH
PRODUCT LINE	Combinatorial Chemistry
PRODUCT CATEGORY	L-Amino Acids

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-101-004-G025		25 g	17.00 USD

Product Specification

FORMULA:	C₆H₁₄N₄O₂
MW:	174.2
CAS NUMBER:	74-79-3
MERCK INDEX:	14: 780
RTECS:	CF1934200
PURITY:	≥98%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Specific Literature References

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation: R.M.J. Palmer, et al.; BBRC 153, 1251 (1988) Abstract
Vascular endothelial cells synthesize nitric oxide from L-arginine: R.M.J. Palmer, et al.; Nature 333, 664 (1988) Abstract
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides: H.H.H.W. Schmidt, et al.; Science 255, 721 (1992) Abstract
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis: M. Joshi; Free Radic. Biol. Med. 22, 573 (1997), (Review) Abstract
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide: C. Didier, et al.; FASEB J. 13, 1817 (1999) Abstract; Full Text
L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways: M.B. Witte, et al.; Metabolism 51, 1269 (2002) Abstract
Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis: E.L. Heinzen & G.M. Pollack; Brain Res. 989, 67 (2003) Abstract
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide: P. Tsai, et al.; Biochem. Pharmacol. 69, 971 (2005) Abstract
Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide: S. Saleh & E. El-Demerdash; Basic Clin. Pharmacol. Toxicol. 97, 91 (2005) Abstract

General Information

Physiological precursor for the formation of nitric oxide (NO) by nitric oxide synthase (NOS). Enhances the release of NO.

Further Categories Containing This Product:

Arginine & Arginases / Related Products • Nitric Oxide Donors

ALX-270-169

Revised 07-Dec-04

Dephostatin
SYNONYMS	2,5-Dihydroxy-N-methyl-N-nitrosoaniline
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Protein Tyrosine Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-169-M001		1 mg	120.00 USD

Product Specification

FORMULA:	C₇H₈N₂O₃
MW:	168.2
CAS NUMBER:	151606-30-3
SOURCE/HOST:	Synthetic.
PURITY:	≥90%
APPEARANCE:	Red to brown solid.
SOLUBILITY:	Soluble in DMSO, chloroform or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Keep under inert gas.

Product Description

Competitive protein tyrosine phosphatase inhibitor. Protein S-nitrosating reagent.

Product Specific Literature References

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization: M. Imoto, et al.; J. Antibiot. 46, 1342 (1993) Abstract
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination: H. Kakeya, et al.; J. Antibiot. 46, 1716 (1993) Abstract
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs: T. Watanabe, et al.; J. Antibiot. 48, 1460 (1995) Abstract
Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin: L. Yu, et al.; Bioorg. Med. Chem. Lett. 5, 1003 (1995)

Further Categories Containing This Product:

Nitric Oxide Donors

ALX-270-213

Revised 13-Dec-06

S-Nitrosocaptopril
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-213-M010		10 mg	60.00 USD
ALX-270-213-M050		50 mg	240.00 USD

Product Specification

FORMULA:	C₉H₁₄N₂O₄S
MW:	246.3
PURITY:	≥98%
APPEARANCE:	Red crystals.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Angiotensin-converting enzyme (ACE) inhibitor. Inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, yielding nitric oxide (NO) and the parent compound, captopril (Prod. No. ALX-270-212).

Product Specific Literature References

S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets: J. Loscalzo, et al.; J. Pharmacol. Exp. Ther. 249, 726 (1989) Abstract
S-nitrosocaptopril. II. Effects on vascular reactivity: J.P. Cooke, et al.; J. Pharmacol. Exp. Ther. 249, 730 (1989) Abstract
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther. 256, 704 (1991) Abstract
Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier: J.W. Park; BBRC 189, 206 (1992) Abstract
Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide: M. Amano, et al.; J. Cardiovasc. Pharmacol. 24, 860 (1994) Abstract
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin: T. Matsumoto, et al.; J. Pharmacol. Exp. Ther. 275, 1247 (1995) Abstract
The effects of S-nitrosocaptopril on canine coronary circulation: I. Nakae, et al.; J. Pharmacol. Exp. Ther. 274, 40 (1995) Abstract
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats: L. Jia & R.C. Blantz; Eur. J. Pharmacol. 354, 33 (1998) Abstract
Physicochemistry, pharmacokinetics, and pharmacodynamics of S-nitrosocaptopril crystals, a new nitric oxide donor: L. Jia, et al.; J. Pharm. Sci. 88, 981 (1999) Abstract
Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor: L. Jia, et al.; Eur. J. Pharmacol. 391, 137 (2000) Abstract
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S-nitrosylated captopril, a nitric oxide donor: L. Jia & H. Wong; Br. J. Pharmacol. 134, 1697 (2001) Abstract
S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats: D.Y. Tsui, et al.; Br. J. Pharmacol. 138, 855 (2003) Abstract
S-nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats: D.Y. Tsui, et al.; J. Pharm. Pharmacol. 55, 1121 (2003) Abstract

Further Categories Containing This Product:

Nitric Oxide Donors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products

ALX-380-010

Revised 08-Oct-08

Streptozotocin
SYNONYMS	Streptozocin 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose STZ
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Nitric Oxide Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-010-M100		100 mg	25.00 USD
ALX-380-010-5100		5x100 mg	65.00 USD
ALX-380-010-G001		1 g	74.00 USD

Product Specification

FORMULA:	C₈H₁₅N₃O₇
MW:	265.2
CAS NUMBER:	18883-66-4
MERCK INDEX:	14: 8832
RTECS:	LZ5775000
PURITY:	≥97%
APPEARANCE:	White to pale yellow solid.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor. Potent methylating agent for DNA.

Product Specific Literature References

Studies on the diabetogenic action of streptozotocin: N. Rakieten, et al.; Cancer Chemother. Rep. 29, 91 (1963)
The structure of streptozotocin: R.R. Herr, et al.; JACS 89, 4808 (1967) Abstract
Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981) Abstract
Streptozotocin: a nitric oxide carrying molecule and its effect on vasodilation: G. Thomas & P. Ramwell; Eur. J. Pharmacol. 161, 279 (1989) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets: J. Turk, et al.; BBRC 197, 1458 (1993) Abstract
Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994) Abstract
Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage: K.-D. Kroncke, et al.; Biol. Chem. Hoppe Seyler 376, 179 (1995) Abstract
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas: T. Szkudelski; Physiol. Res. 50, 537 (2001), (Review) Abstract
Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review) Abstract
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007) Abstract

Further Categories Containing This Product:

Nitric Oxide Donors • Antitumor Antibiotics • Obesity & Diabetes Other Products

ALX-400-001

Revised 06-Oct-08

Sodium nitroprusside . dihydrate
SYNONYMS	Nitroprusside sodium . dihydrate SNP . dihydrate Sodium nitroferricyanide . dihydrate Sodium pentacyanonitrosylferrate . dihydrate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-001-G005		5 g	22.00 USD
ALX-400-001-G025		25 g	45.00 USD

Product Specification

FORMULA:	C₅FeN₆Na₂O . 2H₂O
MW:	261.9 . 36.0
CAS NUMBER:	13755-38-9
MERCK INDEX:	14: 8649
RTECS:	LJ8925000
PURITY:	≥98%
APPEARANCE:	Red to brown solid.
SOLUBILITY:	Soluble in water (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Nitric oxide (NO) donor.

Product Specific Literature References

Sodium nitroprusside protects adult rat cardiac myocytes from cellular injury induced by simulated ischemia: role for a non-cGMP-dependent mechanism of nitric oxide protection: A.M. Garreffa, et al.; J. Cardiovasc. Pharmacol. 47, 1 (2006) Abstract
Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells: H.J. Kim, et al.; Mol. Pharmacol. 69, 1633 (2006) Abstract
No nitric oxide for HO-1 from sodium nitroprusside: H. Schröder; Mol. Pharmacol. 69, 1507 (2006), (Review) Abstract
Effect of NO donor sodium nitroprusside on lipopolysaccharide induced acute lung injury in rats: Z.Y. Xia, et al.; Injury 38, 53 (2006) Abstract

ALX-400-008

Revised 29-Apr-08

Isosorbide dinitrate
SYNONYMS	ISDN
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-008-M100		100 mg	23.00 USD
ALX-400-008-M500		500 mg	35.00 USD

Product Specification

FORMULA:	C₆H₈N₂O₈
MW:	236.1
CAS NUMBER:	87-33-2
MERCK INDEX:	14: 5225
PURITY:	Contains ~60% lactose
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water/acetone (1:1) (50mg/ml); sparingly soluble in water; freely soluble in organic solvents.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	May be explosive upon heating.
HAZARD:	HARMFUL.

Product Description

Nitric oxide (NO) donor.

Product Specific Literature References

Isosorbide dinitrate pharmacokinetics: T. Taylor, et al.; Arzneimittelforschung 32, 1329 (1982) Abstract
Inhibition of platelet aggregation by isosorbide dinitrate: J. Ahlner, et al.; Am. J. Cardiol. 58, 665 (1986) Abstract
Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate: N. Mukerjee & R. Pietruszko; J. Biol. Chem. 269, 21664 (1994) Abstract; Full Text
Effects of nitric oxide donor, isosorbide dinitrate, on energy metabolism of rat reticulocytes: S. D. Maletic, et al.; Physiol. Res. 48, 417 (1999) Abstract; Full Text
Effect of isosorbide dinitrate on nitric oxide synthase under hypoxia: H.B. Jiang, et al.; Pharmacology 62, 10 (2001) Abstract

ALX-400-009

Revised 09-Mar-07

SIN-1A/γCD Complex
SYNONYMS	3-Morpholino-N-nitroso-aminoacetonitrile . γ-cyclodextrin complex
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-009-M005		5 mg*	95.00 USD
ALX-400-009-M025		25 mg*	380.00 USD

Product Specification

QUANTITY:	* Sold by net SIN-1A content.
APPEARANCE:	Pale yellow powder.
FORMULATION:	The complex contains 10 ± 2% of SIN-1A. SIN-1 content: not detectable. SIN-1C (N-morpholinoiminoacetonitrile) content: 0.5 ± 0.2%.
SOLUBILITY:	Well soluble in distilled water, isotonic saline, phosphate buffer or HCl solution, pH 1.4.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Physiologically active nitric oxide (NO) releasing agent. Releasing one equivalent of NO the half life time at room temperature is ~40 minutes mostly independent from the pH.

ALX-420-002

Revised 03-Sep-07

GSNO
SYNONYMS	S-Nitroso-L-glutathione
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-002-M025		25 mg	80.00 USD
ALX-420-002-M100		100 mg	240.00 USD

Product Specification

FORMULA:	C₁₀H₁₆N₄O₇S
MW:	336.3
CAS NUMBER:	57564-91-7
PURITY:	≥98%
APPEARANCE:	Pink crystalline solid.
SOLUBILITY:	Soluble in DMSO or PBS; sparingly soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation.

Product Specific Literature References

An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus: A. Gibson, et al.; Br. J. Pharmacol. 107, 715 (1992) Abstract
S-nitroso-glutathione inhibits platelet activation in vitro and in vivo: M.W. Radomski, et al.; Br. J. Pharmacol. 107, 745 (1992) Abstract
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000) Abstract; Full Text
S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke: M. Khan, et. al.; J. Cereb. Blood Flow Metab. 25, 177 (2005) Abstract
Protection from experimental asthma by an endogenous bronchodilator: G. Que, et al.; Science 308, 1618 (2005) Abstract
Redox regulation of PTEN by S-nitrosothiols: C.X. Yu, et al.; Mol. Pharmacol. 68, 847 (2005) Abstract; Full Text
Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells: H. K. Jeon, et al.; Cell. Biol. Toxicol. 21, 115 (2005) Abstract
Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione: L. Chen, et al.; J. Biol. Chem. 281, 9190 (2006) Abstract
Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds: D. McGrowder, et al.; J. Biosci. 31, 347 (2006) Abstract
Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner: M. C. Gonzalez-Leon, et al.; J. Endotoxin Res. 12, 296 (2006) Abstract
GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions: R. Prasad, et al.; Glia 55, 65 (2007) Abstract

ALX-420-003

Revised 07-Jun-07

SNAP
SYNONYMS	S-Nitroso-N-acetyl-D,L-penicillamine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-003-M005		5 mg	28.00 USD
ALX-420-003-M025		25 mg	55.00 USD
ALX-420-003-M100		100 mg	195.00 USD

Product Specification

FORMULA:	C₇H₁₂N₂O₄S
MW:	220.3
CAS NUMBER:	79032-48-7
PURITY:	≥98%
APPEARANCE:	Green crystalline solid.
SOLUBILITY:	Soluble in DMSO or methanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Stable analog of endogenous S-nitroso compounds. Nitric oxide (NO) donor and a source of NO in vivo. The half-life time is ~5 hours in aqueous media. Compare also Glyco-SNAP-1 (Prod. No. ALX-420-016) and Glyco-SNAP-2 (Prod. No. ALX-420-017).

Product Specific Literature References

Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure: J.A. Bauer & H.-L. Fung; J. Pharmacol. Exp. Ther. 256, 249 (1991) Abstract
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus: A. Gibson, et al.; Br. J. Pharmacol. 107, 715 (1992) Abstract
S-nitroso-glutathione inhibits platelet activation in vitro and in vivo: M.W. Radomski, et al.; Br. J. Pharmacol. 107, 745 (1992) Abstract
Lack of tolerance to a 24-hour infusion of S-nitroso N- acetylpenicillamine (SNAP) in conscious rabbits: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther. 260, 286 (1992) Abstract
Nitric oxide donor SNAP induces apoptosis in smooth muscle cells through cGMP-independent mechanism: E. Nishio, et al.; BBRC 221, 163 (1996) Abstract
Modulation of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) induced HL-60 cell death by tetrahydrobiopterin: S. Kojima, et al.; Anticancer Res. 17, 929 (1997) Abstract
In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl- penicillamine, towards cells from human oral tissue: H. Babich, et al.; Pharmacol. Toxicol. 84, 218 (1999)