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ALX-350-312 Revised 28-May-08
(-)-Arctigenin
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SYNONYMS (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-312-M025   25 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H24O6
MW: 372.4
CAS NUMBER: 7770-78-7
SOURCE/HOST: Isolated from Arctium lappa.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (34mg/ml, heating, sonication); sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca2+. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
Product Specific Literature References
Antiproliferative effect of Arctigenin and Arctiin: S.Y. Ryu, et al.; Arch. Pharm. Res. 18, 462 (1995)
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase: E. Eich, et al.; J. Med. Chem 39, 86 (1996) Abstract
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation: J.Y. Cho, et al.; J. Pharm. Pharmacol. 51, 1267 (1999) Abstract
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor: Y.P. Jang, et al.; J. Neurosci. Res. 68, 233 (2002) 68, 233 (2002) Abstract
A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris: A. Koulman, et al.; Planta Med. 69, 733 (2003) Abstract
Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells: B. Hausott, et al.; J. Cancer Res. Clin. Oncol. 129, 569 (2003) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation: S. Awale, et al.; Cancer Res. 66, 1751 (2006) Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme: K. Kang, et al.; Biol. Pharm. Bull. 30, 2352 (2007) Abstract
 
 
ALX-350-318 Revised 17-Jun-08
(-)-Arctiin
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SYNONYMS (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-318-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C27H34O11
MW: 534.6
CAS NUMBER: 20362-31-6
SOURCE/HOST: Isolated from Arctium lappa.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml); sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description

Lignan derivative with antitumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor and Ca2+.

Product Specific Literature References
Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes: S. Iwakami, et al.; Chem. Pharm. Bull. (Tokyo) 40, 1196 (1992) Abstract
Antiproliferative effect of Arctigenin and Arctiin: S.Y. Ryu, et al.; Arch. Pharm. Res. 18, 462 (1995)
Cytotoxic components of bardanae fructus (goboshi): S. Moritani, et al.; Biol. Pharm. Bull. 19, 1515 (1996) Abstract
Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection: A.J. Vlietinck, et al.; Planta Med. 64, 97 (1998) Abstract
Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa: M. Takasaki, et al.; Cancer Lett. 158, 53 (2000) Abstract
Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS: S. Liu, et al.; Phytochem. Anal. 16, 86 (2005) Abstract
Application of preparative high-speed counter-current chromatography for separation and purification of arctiin from Fructus Arctii: X. Wang, et al.; J. Chromatogr. A. 1063, 247 (2005) Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme: K. Kang, et al.; Biol. Pharm. Bull. 30, 2352 (2007) Abstract
 
 
ALX-201-290 Revised 06-Aug-08
ARH1 (human) (recombinant) (His)
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SYNONYMS ADP-ribosylarginine Hydrolase (human) (recombinant) (His)
ADPRH (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
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ALX-201-290-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.2.19
SOURCE/HOST: Produced in E. coli. Human ARH1 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of ADP-ribosylagmatine and proteins ADP-ribosylated on arginine residues
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P54922: ADPRH (human)
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-292 Revised 06-Aug-08
ARH3 (human) (recombinant) (His)
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SYNONYMS ADP-ribosylhydrolase 3 (human) (recombinant) (His)
ADPRHL2 (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
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ALX-201-292-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.1.143
SOURCE/HOST: Produced in E. coli. Human ARH3 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of poly-ADP-ribosylated proteins
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9NX46: ADPRHL2 (human)
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix: M. Niere, et al.; Mol. Cell. Biol. 28, 814 (2008) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-291 Revised 06-Aug-08
ARH1 (mouse) (recombinant) (His)
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SYNONYMS ADP-ribosylarginine Hydrolase (mouse) (recombinant) (His)
Adprh (mouse) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-291-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.2.19
SOURCE/HOST: Produced in E. coli. Mouse ARH1 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of ADP-ribosylagamatine and proteins ADP-ribosylated on arginine residues.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P54923: Adprh (mouse)
General Literature References
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases: P. Konczalik & J. Moss; J. Biol. Chem. 274, 16736 (1999) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice: J. Kato, et al.; Mol. Cell. Biol. 27, 5534 (2007) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-293 Revised 06-Aug-08
ARH3 (mouse) (recombinant) (His)
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SYNONYMS ADP-ribosylhydrolase 3 (mouse) (recombinant) (His)
Adprhl2 (mouse) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-293-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.1.143
SOURCE/HOST: Produced in E. coli. Mouse ARH3 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of poly-ADP-ribosylated proteins
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Structure of mouse ADP-ribosylhydrolase 3 (mARH3): C. Mueller-Dieckmann, et al.; Acta Crytallogr. Sect. F Struct. Biol. Cryst. Commun. 64, 156 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8CG72: Adprhl2 (mouse)
General Literature References
The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse: G. Glowacki, et al.; Protein Sci. 11, 1657 (2002) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix: M. Niere, et al.; Mol. Cell. Biol. 28, 814 (2008) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-129 Revised 04-Dec-07
Aristoforin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-129-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C37H54O6
MW: 594.8
CAS NUMBER: 849215-53-8
PURITY: ≥95%
APPEARANCE: White to yellow oil.
SOLUBILITY: Soluble in DMSO or 100mM sodium hydrogen carbonate/2% DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Stable and water-soluble derivative of hyperforin (Prod. No. ALX-350-097) inducing apoptosis. Antitumor agent. Inhibits sirtuins.
Product Specific Literature References
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem. 6, 171 (2005) Abstract
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2: C. Gey, et al.; Angew. Chem. Int. Ed. Engl. 46, 5219 (2007) Abstract
 
 
ALX-201-289 Revised 06-Aug-08
ART2.2 (mouse) (recombinant) (His)
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SYNONYMS ecto-ADP-ribosyltransferase 2.2 (mouse) (recombinant) (His)
ART2b (mouse) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-289-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.31
SOURCE/HOST: Produced in E. coli. Mouse ART2.2 is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): catalyzes ADP-ribosylation of P2RX7 on R125 and R133, agmatine and numerous other proteins (LFA-1, histones, protamine)
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse: G. Glowacki, et al.; Protein Sci. 11, 1657 (2002) Abstract; Full Text
Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo: F. Koch-Nolte, et al.; FASEB J. 21, 3490 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O35975: ART2b (mouse)
General Literature References
Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins: F. Koch-Nolte; J. Biol. Chem. 271, 7686 (1996) Abstract; Full Text
Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria: A. Herrero-Yraola, et al.; EMBO J. 20, 2404 (2001) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts: P. Bannas, et a