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ALX-804-847
Revised 19-Jun-08
Monoclonal Antibody to Cardif (human) (Adri-1)
SYNONYMS
anti-CARD Adapter Inducing Interferon-β (human) MAb (Adri-1)
anti-IPS-1 Cardif (human) MAb (Adri-1)
anti-Interferon-β Promoter Stimulator Protein 1 (human) MAb (Adri-1)
anti-MAVS (human) MAb (Adri-1)
anti-Mitochondrial Antiviral Signalling Protein (human) MAb (Adri-1)
anti-VISA (human) MAb (Adri-1)
anti-Virus-induced Signalling Adapter (human) MAb (Adri-1)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Antiviral Signalling / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-847-C100
100 µg
370.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Adri-1
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human Cardif (CARD adapter inducing interferon-β) (aa 160-450).
SPECIFICITY:
Recognizes human Cardif.
APPLICATION:
Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway:
M.C. Michallet, et al.; Immunity
28
, 651 (2008)
Abstract
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-κB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons.
Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-κB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-β production.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus:
E. Meylan, et al.; Nature
437
, 1167 (2005)
Abstract
VISA is an adapter protein required for virus-triggered IFN-beta signaling:
L.G. Xu, et al.; Mol. Cell
19
, 727 (2005)
Abstract
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction:
T. Kawai, et al.; Nat. Immunol.
6
, 981 (2005)
Abstract
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3:
R.B. Seth, et al.; Cell
122
, 669 (2005)
Abstract
CARD games between virus and host get a new player:
C.L. Johnson and M. Gale, Jr.; Trends Immunol.
27
, 1 (2006)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-804-726
Revised 03-Dec-08
Monoclonal Antibody to IL-33 (human) (IL33305B)
SYNONYMS
anti-Interleukin-33 (human) MAb (IL33305B)
anti-NF-HEV (human) MAb (IL33305B)
anti-IL-1F11 (human) MAb (IL333305B)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-726-C050
50 µg
195.00 USD
ALX-804-726-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
IL33305B
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human IL-33 (interleukin-33).
SPECIFICITY:
Recognizes human IL-33. Does not cross-react with mouse IL-33.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry
(paraffin sections (1:50-1:200)
Immunoprecipitation
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Functional Application
(Neutralization)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1-2 weeks when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products
•
Polyclonal Antibodies
ALX-804-728
Revised 02-Oct-08
Monoclonal Antibody to IL-33 (IL33026B)
SYNONYMS
anti-Interleukin-33 MAb (IL33026B)
anti-NF-HEV MAb (IL33026B)
anti-IL-1F11 MAb (IL33026B)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-728-C050
50 µg
195.00 USD
ALX-804-728-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
IL33026B
ISOTYPE:
Mouse IgG1κ
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human IL-33 (interleukin-33).
SPECIFICITY:
Recognizes human and mouse IL-33.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1-2 weeks when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products
•
Polyclonal Antibodies
ALX-804-727
Revised 02-Oct-08
Monoclonal Antibody to IL-33 (IL33068A)
SYNONYMS
anti-Interleukin-33 MAb (IL33068A)
anti-NF-HEV MAb (IL33068A)
anti-IL-1F11 MAb (IL33068A)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-727-C050
50 µg
195.00 USD
ALX-804-727-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
IL33068A
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human IL-33 (interleukin-33).
SPECIFICITY:
Recognizes human IL-33. Weakly cross-reacts with mouse IL-33.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1-2 weeks when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products
•
Polyclonal Antibodies
ALX-804-854
Revised 29-Oct-07
Monoclonal Antibody to Nesfatin-1 (Nesfaty-1)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Nesfatin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-854-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE:
Nesfaty-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant rat nesfatin-1 (aa 25-106) (Prod. No.
ALX-522-118
).
SPECIFICITY:
Recognizes mouse and rat nesfatin-1 and precursor nucleobindin-2.
APPLICATION:
ELISA
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus:
I.S. Oh, et al.; Nature
443
, 709 (2006)
Abstract
Related Products
ALX-522-112
Nesfatin-1 (mouse) (recombinant)
ALX-522-114
Nesfatin-1 (mouse) (recombinant) (tagged)
ALX-522-116
Nesfatin-1 (rat) (recombinant)
APO-54N-036
Nesfatin-1 (mouse/rat) Detection Set [For ELISA Application]
ALX-522-118
Nesfatin-1 (rat) (recombinant) (tagged)
ALX-210-944
Polyclonal Antibody to Nesfatin-1 (AT120)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-804-851
Revised 03-May-07
Monoclonal Antibody to RGMC (human) (Fery-1)
SYNONYMS
anti-Repulsive Guidance Molecule C (human) MAb (Fery-1)
anti-Hemojuvelin (human) MAb (Fery-1)
anti-Hemochromatosis Type 2 Protein (human) MAb (Fery-1)
anti-HFE2 (human) MAb (Fery-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-851-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Fery-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RGMC (aa 36-398) (Prod. No.
ALX-522-104
).
SPECIFICITY:
Recognizes human RGMC.
APPLICATION:
Flow Cytometry
Immunoprecipitation
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-104
RGMC, Soluble (human) (recombinant)
Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
•
Polyclonal Antibodies
ALX-804-849
Revised 16-Aug-07
Monoclonal Antibody to RIG-I (Alme-1)
SYNONYMS
anti-RIG-1 MAb (Alme-1)
anti-Retinoic Acid-inducible Gene 1 Protein MAb (Alme-1)
anti-DEAD-box Protein 58 MAb (Alme-1)
anti-Probable ATP-dependent RNA Helicase DDX58 MAb (Alme-1)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-849-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Alme-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).
SPECIFICITY:
Recognizes human and mouse RIG-I.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:100)
Western blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Virology. Sensing viral RNA amid your own:
T. Fujita; Science
314
, 935 (2006)
Abstract
5’-Triphosphate RNA is the ligand for RIG-I:
V. Hornung, et al.; Science
314
, 994 (2006)
Abstract
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates:
A. Pichlmair, et al.; Science
314
, 997 (2006)
Abstract
Related Products
ALX-210-932
Polyclonal Antibody to RIG-I (human) (AT111)
ALX-840-609
Positive Control (Cell Lysate) for Antibodies to RIG-I (human)
APO-54N-038
RIG-I (human) (IntraCellular) Detection Set [For ELISA Application]
Further Categories Containing This Product:
Antiviral Signalling / Related Products
•
NF-kB Pathway Other Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Interferons & Interferon Receptors Other Products
•
Polyclonal Antibodies
ALX-804-644
Revised 29-May-07
Monoclonal Antibody to RORα (human) (6E8)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-644-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
6E8
ISOTYPE:
Mouse IgG1
CONCENTRATION:
~580µg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.6. Contains no preservatives.
IMMUNOGEN:
Recombinant human RORα.
SPECIFICITY:
Recognizes human RORα1-4. The epitope is located at aa 84-105 of RORα4.
APPLICATION:
Electrophoretic Mobility Shift Assay (EMSA)
Immunoprecipitation
Western Blot (2µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for 12 months after receipt when stored at +4°C.
HANDLING:
Do not freeze.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Intracellular localization of RORalpha is isoform and cell line-dependent:
A. Aschrafi, et al.; Biochim. Biophys. Acta
1763
, 805 (2006)
Abstract
Overexpression, refolding, and purification of polyhistidine-tagged human retinoic acid related orphan receptor RORalpha4:
A. Lechtken, et al.; Protein Expr. Purif.
49
, 114 (2006)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-804-855
Revised 06-Aug-07
Monoclonal Antibody to TL1A (mouse) (Tingo-1)
SYNONYMS
anti-TNFSF 15 (mouse) MAb (Tingo-1)
anti-VEGI (mouse) MAb (Tingo-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
HVEM & LIGHT / LT-betaR / DcR3 / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-855-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Tingo-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse TL1A extracellular domain (aa 94-252) (Prod. No.
ALX-522-105
).
SPECIFICITY:
Recognizes mouse TL1A.
APPLICATION:
ELISA
Immunoprecipitation (1:50)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
