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ALX-385-024 Revised 06-Oct-08
Isorhamnetin
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SYNONYMS 3-Methylquercetin
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-024-M005   5 mg 90.00 USD Add To Cart
ALX-385-024-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O7
MW: 316.3
CAS NUMBER: 480-19-3
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone, methanol, ethylacetate or DMSO. Only sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antiviral agent. Antioxidant. Antitumor compound. Apoptosis inducer.
Product Specific Literature References
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima: H. Ito, et al.; Cancer Lett. 143, 5 (1999) Abstract
Inhibition of xanthine oxidase by flavonoids: A. Nagao, et al.; Biosci. Biotechnol. Biochem. 63, 1787 (1999) Abstract
Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products: L. Zou, et al.; Phytomedicine 9, 263 (2002) Abstract
Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes: T. Yokozawa, et al.; J. Agric. Food Chem. 50, 5490 (2002) Abstract
Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils: G. Chen, et al.; Clin. Chim. Acta 326, 169 (2002) Abstract
Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK: M. Bao & Y. Lou; Eur. J. Pharmacol. 547, 22 (2006) Abstract
The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells: G. Ma, et al.; Chem. Biol. Interact. 167, 153 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-445-009 Revised 21-Aug-08
12-Deoxyphorbol 13-acetate
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SYNONYMS Prostratin
13-Acetyl-12-deoxyphorbol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Phorbols / Phorbol Esters
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-445-009-M001   1 mg 80.00 USD Add To Cart
ALX-445-009-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C22H30O6
MW: 390.5
CAS NUMBER: 60857-08-1
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. IRRITANT.

Product Description
Protein kinase C (PKC) activator that does not induce tumor formation. Upregulates latent HIV-1 provirus expression and inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle.
Product Specific Literature References
The structure of prostratin: A toxic tetracyclic diterpene ester from Pimelea prostrata.: A.R. Cashmore, et al.; Tetrahedron Lett. 20, 1737 (1976)
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia 33, 1554 (1977) Abstract
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res. 53, 2507 (1993) Abstract
Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem. 279, 42008 (2004) Abstract
Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect. 18, 496 (2005), (Review) Abstract
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T. L. Sung & A. P. Rice; Retrovirology 3, 66 (2006) Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • HIV / AIDS / Related Products
 
 
ALX-480-048 Revised 06-Mar-07
2',3'-Dideoxyadenosine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-048-M001   1 mg 15.00 USD Add To Cart
ALX-480-048-M005   5 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O2
MW: 235.2
CAS NUMBER: 4097-22-7
MERCK INDEX: 14: 3101
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of adenylate cyclase. Useful tool in antiviral and anticancer studies. Blocks viral reverse transcription from RNA to DNA. Inhibitor of adenosine deaminase.
Product Specific Literature References
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'- dideoxyinosine: V. Nair & T.B. Sells; Biochim. Biophys. Acta 1119, 201 (1992) Abstract
Long-term inhibn. of human T-lymphotropic virus type III/lymphadenopathy-associated virus DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro: H. Mitsuya, et al.; PNAS 84, 2033 (1987) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors • Antiviral Agents Other Products
 
 
ALX-480-049 Revised 03-Jun-08
2',5'-Dideoxyadenosine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-049-M001   1 mg 30.00 USD Add To Cart
ALX-480-049-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O2
MW: 235.2
CAS NUMBER: 6698-26-6
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.

Product Description
Cell permeable inhibitor of adenylate cyclase (ID50=250µM [1]; inhibition also reported at 1mM [2]). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells [6].
Product Specific Literature References
[1] Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose- modified adenosine analogs: S.T. Holgate, et al.; PNAS 77, 6800 (1980) Abstract
[2] Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni, et al.; J. Pharmacol. Exp. Ther. 259, 508 (1991) Abstract
[3] Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa, et al.; Digestion 54, 135 (1993) Abstract
[4] Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol. 25, 331 (1993) Abstract
[5] Erythroid differentiation and growth inhibition of K562 cells by 2',5'-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa, et al.; Leuk. Res. 19, 749 (1995) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors • Antiviral Agents Other Products
 
 
ALX-630-112 Revised 14-Jan-08
Stachybotrylactam
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SYNONYMS 2-Deoxy Antibiotic F1839A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-112-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C23H31NO4
MW: 385.5
CAS NUMBER: 163391-76-2
SOURCE/HOST: Isolated from Stachybotrys sp. MST-FP1752.
PURITY: ≥95% (HPLC)
APPEARANCE: Light tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Mycotoxin. Immunosuppressive. Weakly inhibits HIV-1 protease.
Product Specific Literature References
Stachybotrys toxins. 1: B.B. Jarvis, et al.; Nat. Toxins 3, 10 (1995) Abstract
Novel spirodihydrobenzofuranlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys Sp. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo) 49, 13 (1996) Abstract
Enantioselective total synthesis and structure revision of spirodihydrobenzofuranlactam 1. Total synthesis of stachybotrylactam: A.S. Kende, et al.; Org. Lett. 5, 1785 (2003) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • HIV / AIDS / Related Products
 
 
ALX-746-022 Revised 11-Sep-08 New product
Poly(deoxyadenosine:deoxythymidine) (endotoxin-free) (synthetic)
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SYNONYMS Poly(dA:dT) (endotoxin-free) (synthetic)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antiviral Signalling / Related Products
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ALX-746-022-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Synthetic.
QUANTITY: Aliquoted by weight of dry material. Contains polymer, residual salt and water. Sufficient for at least 200 cellular activation assays at 0.025-0.25µg/200µl.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 250µg/ml stock solution, dissolve the total vial content in 200µl endotoxin-free buffer or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20°C. Protect from light.
Product Description
Strong IFN inducer, independent of IRF3.
General Information
BACKGROUND/TECHNICAL INFORMATION

For in vitro stimulation we recommend the following procedure:
1. Bone marrow-derived mouse dendritic cells (BM mDC) are cultured 8x104/100µl in RPMI containing 10% FCS over night at 5% CO2 and 37°C.
2. The medium is removed and replaced by 100µl OPTI MEM (Invitrogen) and subsequently the transfection mixture is added: 25µl OPTI MEM containing 0.025 to 0.25 Poly(dA:dT) + 25µl OPTI MEM containing 0.5µl Lipofectamine 2000 (Invitrogen) or alternative transfection agents.
3. Over night stimulation at 5% CO2 and 37°C.
4. Measurement of IFN-α/β in culture supernatants.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response : A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
Cytosolic DNA recognition for triggering innate immune responses: A. Takaoka & T. Taniguchi; Adv. Drug Deliv. Rev. 60, 847 (2008) Abstract
Intracellular pattern-recognition receptors  : C. Dostert, et al.; Adv. Drug Deliv. Rev. 60, 830 (2008) Abstract
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response: D.A. Muruve, et al.; Nature 452, 103 (2008) Abstract
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ALX-746-023 Revised 11-Sep-08 New product
Oligo(deoxyadenosine:deoxythymidine) (endotoxin-free) (synthetic)
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SYNONYMS Oligo(dA:dT) (endotoxin-free) (synthetic)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antiviral Signalling / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-023-C050   50 µg 250.00 USD Add To Cart
Product Specification
SOURCE/HOST: Synthetic.
QUANTITY: Aliquoted by weight of dry material. Contains polymer, residual salt and water. Sufficient for at least 200 cellular activation assays at 0.01-0.025µg/ml.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 250µg/ml stock solution, dissolve the total vial content in 200µl endotoxin-free buffer or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Description
Strong IFN inducer, dependent of IRF3.
General Information
BACKGROUND/TECHNICAL INFORMATION For in vitro stimulation we recommend the following procedure:
1. Bone marrow-derived mouse dendritic cells (BM mDC) are cultured 8x104/100μl in RPMI containing
10% FCS over night at 5% CO2 and 37°C.
2. The medium is removed and replaced by 100μl OPTI MEM (Invitrogen) and subsequently
the transfection mixture is added: 25μl OPTI MEM containing 0.025 to 0.25 Poly(dA:dT) + 25μl OPTI MEM
containing 0.5μl Lipofectamine 2000 (Invitrogen) or alternative transfection agents.
3. Over night stimulation at 5% CO2 and 37°C.
4. Measurement of IFN-α/β in culture supernatants.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response: A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
Cytosolic DNA recognition for triggering innate immune responses: A. Takaoka & T. Taniguchi; Adv. Drug Deliv. Rev. 60, 847 (2008) Abstract
Intracellular pattern-recognition receptors: C. Dostert, et al.; Adv. Drug. Deliv. Rev. 60, 830 (2008) Abstract
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response: D.A. Muruve, et al.; Nature 452, 103 (2008) Abstract
Related Products
 
 
ALX-803-059 Revised 27-Apr-06
Monoclonal Antibody to NS3 (HCV) (1B6)
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SYNONYMS anti-Nonstructural Protein 3 (HCV) MAb (1B6)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-059-R100   100 µl 360.00 USD Add To Cart
Product Specification
CLONE: 1B6
ISOTYPE: Mouse IgG1
PURITY: Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
SPECIFICITY: Recognizes HCV NS3 (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex.
APPLICATION: Immunocytochemistry (1:50)
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines: B. Wolk, et al.; J. Virol. 74, 2293 (2000) Abstract; Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins: Dimitrova, et al.; J. Virol. 77, 5401 (2003) Abstract; Full Text
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons: R. Gosert, et al.; J. Virol. 77, 5487 (2003) Abstract; Full Text
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes: D. Moradpour, et al.; J. Virol. 78, 7400 (2004) Abstract; Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005) Abstract; Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-060 Revised 27-Apr-06
Monoclonal Antibody to NS5B (HCV) (5B-3B1)
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SYNONYMS anti-Nonstructural Protein 5B (HCV) MAb (5B-3B1)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-060-R100   100 µl 360.00 USD Add To Cart
Product Specification
CLONE: 5B-3B1
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY: Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382).
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002) Abstract; Full Text
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells: R.W. Hardy, et al.; J. Virol. 77, 2029 (2003) Abstract; Full Text
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs: G. Randall, et al.; PNAS 100, 235 (2003) Abstract; Full Text
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005) Abstract; Full Text
Quantitative analysis of the hepatitis C virus replication complex: D. Quinkert, et al.; J. Virol. 79, 13594 (2005) Abstract
Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3: Y.V. Svitkin, et al.; J. Virol. 79, 6868 (2005) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation
General Literature References