ALEXIS Biochemicals: Zinquin ethyl ester

You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Apoptosis Inducers & Inhibitors > Apoptosis Inducers & Inhibitors Other Products

ALX-620-044

Revised 22-Apr-08

Zinquin ethyl ester
SYNONYMS	(2-Methyl-8-(4-methylphenylsulfonylamino)quinolinyl)oxyacetic acid ethyl ester
PRODUCT LINE	Other Products
PRODUCT CATEGORY	Dyes / Stains / Fluorescent Probes / Fluorescent Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-620-044-M001		1 mg	80.00 USD
ALX-620-044-M005		5 mg	320.00 USD

Product Specification

FORMULA:	C₂₁H₂₂N₂O₅S
MW:	414.5
PURITY:	≥95%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol or DMSO; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Fluorescent, membrane permeable probe of zinc ions which can be used to measure or visualize intracellular zinc. Used to demonstrate changes in zinc flux in cells undergoing early events of apoptosis.

Product Specific Literature References

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II): P.D. Zalewski, et al.; Biochem. J. 296, 403 (1993) Abstract
Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin: P.D. Zalewski, et al.; Chem. Biol. 1, 153 (1994) Abstract
Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc: P. Coyle, et al.; Biochem. J. 303, 781 (1994) Abstract
Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc: P.D. Zalewski, et al.; J. Histochem. Cytochem. 42, 877 (1994) Abstract
Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes: I.A. Brand & J. Kleineke; J. Biol. Chem. 271, 1941 (1996) Abstract; Full Text

General Information

Zinc (Zn) is the second most abundant transition metal in the body ant it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer’s disease, Parkinson’s disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluroescent imaging.

General Literature References

Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors: P. Jiang & Z. Guo; Coord. Chem. Rev. 248, 205 (2004) Full Text
Zinc: a multipurpose trace element: M. Stefanidou, et al.; Arch. Toxicol. 80, 1 (2006) Abstract
Sticky fingers: zinc-fingers as protein-recognition motifs: R. Gamsjaeger, et al.: R. Gamsjaeger, et al.; TIBS 32, 63 (2007) Abstract
Mechanism and regulation of cellular zinc transport: I. Sekler, et al.; Mol. Med. 13, 337 (2007) Abstract; Full Text

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.