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ALX-804-272 Revised 13-Jun-08
Monoclonal Antibody to STAT6 (phosphorylated) (pTyr641) (16E12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-272-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 16E12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of human STAT6 phophorylated at Tyr641.
SPECIFICITY: Recognizes the GRGpYVPA motif of human, mouse (weak) and rat (weak) activated STAT6 phosphorylated at Tyr641. Does not cross-react with the non-phosphorylated form of STAT6 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION: Immunohistochemistry
Western Blot (1HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-018).
Product Specific Literature References
IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos: A. Lorentz, et al.; J. Immunol. 174, 6751 (2005) Abstract; Full Text
General Information
STATs (signal transducing activators of transcription) are mediators involved in cytokine signalling. In response to a specific cytokine signal, STATs move to the nucleus and induce transcription. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinases (JAKs). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it participates in transcriptional control.
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies • Autophagy Other Products
 
 
ALX-804-367 Revised 04-Nov-08
Monoclonal Antibody to Bif-1 (human) (30A882.1.1)
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SYNONYMS anti-Bax Interacting Factor-1 (human) MAb (30A882.1.1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-367-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 30A882.1.1
ISOTYPE: Mouse IgG
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human Bif-1 (Bax interacting factor-1).
SPECIFICITY: Recognizes human Bif-1.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

Stable for 6 months when stored at +4°C.
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Product Specific Literature References
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text
Endophilin B1 is required for the maintenance of mitochondrial morphology: M. Karbowski, et al.; J. Cell Biol. 166, 1027 (2004) Abstract
General Literature References
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis: Y. Takahashi, et al.; Nat. Cell Biol. 9, 1142 (2007) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • Autophagy Other Products
 
 
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