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Nitric Oxide Pathway
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ALX-420-006 Revised 15-Aug-06
Aminoguanidine . hydrochloride
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-006-M100   100 mg 20.00 USD Add To Cart
ALX-420-006-M500   500 mg 45.00 USD Add To Cart
Product Specification
FORMULA: CH6N4 . HCl
MW: 74.1 . 36.5
CAS NUMBER: 1937-19-5
MERCK INDEX: 14: 441
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of nitric oxide synthase (NOS).
Product Specific Literature References
Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction: J.A. Corbett, et al.; Diabetes 41, 552 (1992) Abstract
Selective inhibition of the inducible nitric oxide synthase by aminoguanidine: T.P. Misko, et al.; Eur. J. Pharmacol. 233, 119 (1993) Abstract
Aminoguanidine selectively inhibits inducible nitric oxide synthase: M.J. Griffiths, et al.; Br. J. Pharmacol. 110, 963 (1993) Abstract
Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice: A.H. Cross, et al.; J. Clin. Invest. 93, 2684 (1994) Abstract
Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo: F. Laszlo, et al.; Eur. J. Pharmacol. 272, 169 (1995) Abstract
Selective inhibition of inducible nitric oxide synthase by aminoguanidine: J.A. Corbett & M.L. McDaniel; Methods Enzymol. 268, 398 (1996) Abstract
 
 
ALX-270-008 Revised 07-May-03
(2S)-(+)-Amino-6-iodoacetamidohexanoic acid
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SYNONYMS AIAH
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-008-M005   5 mg 42.00 USD Add To Cart
ALX-270-008-M025   25 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C8H15N2O3I
MW: 314.1
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 6N aq. HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible inhibitor of arginase.
Product Specific Literature References
Uterine arginase inhibition affect the rat embryonic development: J.D. Méndez, et al.; Contraception 33, 597 (1986) Abstract
J.G. Trujillo, et al.; Synth. Commun. 21, 683 (1991)
Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase: C.A. Robertson, et al.; BBRC 197, 523 (1993) Abstract
Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages: A. Hrabak, et al.; BBRC 198, 206 (1994) Abstract
 
 
ALX-270-007 Revised 07-Jun-06
(2S)-(+)-Amino-5-iodoacetamidopentanoic acid
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SYNONYMS AIAP
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-007-M005   5 mg 42.00 USD Add To Cart
ALX-270-007-M025   25 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C7H13N2O3I
MW: 300.1
CAS NUMBER: 35748-65-3
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 6N aq. HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible inhibitor of arginase.
Product Specific Literature References
Uterine arginase inhibition affect the rat embryonic development: J.D. Méndez, et al.; Contraception 33, 597 (1986) Abstract
J.G. Trujillo, et al.; Synth. Commun. 21, 683 (1991)
Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase: C.A. Robertson, et al.; BBRC 197, 523 (1993) Abstract
Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages: A. Hrabák, et al.; BBRC 198, 206 (1994) Abstract
 
 
ALX-270-449 Revised 20-Mar-07
2-Amino-4-methylpyridine
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SYNONYMS 2-Amino-4-picoline
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-449-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H8N2
MW: 108.1
CAS NUMBER: 695-34-1
MERCK INDEX: 14: 466
RTECS: TJ5150000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethylformamide or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 3 years after receipt when stored at -20°C.
HAZARD: TOXIC.

Product Description

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) both in vitro and in vivo. Analgesic agent.
Product Specific Literature References
2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo: W.S. Faraci, et al.; Br. J. Pharmacol. 119, 1101 (1996) Abstract
Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor: E.R. Pettipher, et al.; Inflamm. Res. 46 Suppl 2, S135 (1997) Abstract
Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine: S.Y. Saad, et al.; Chemotherapy 48, 309 (2002) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-270-029 Revised 03-Mar-05
S-(3-Aminopropyl)-ITU . dihydrobromide
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SYNONYMS S-(3-Aminopropyl)isothiourea . 2HBr
2-(3-Aminopropyl)-2-thiopseudourea . 2HBr
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-029-M010   10 mg 40.00 USD Add To Cart
ALX-270-029-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C4H13N3S . 2HBr
MW: 133.2 . 161.8
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Nitric oxide synthase (NOS) inhibitor, relatively selective for inducible nitric oxide synthase (iNOS/NOS II).
Product Specific Literature References
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas: E.P. Garvey, et al.; J. Biol. Chem. 269, 26669 (1994) Abstract; Full Text
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity: G.J. Southan, et al.; Br. J. Pharmacol. 114, 510 (1995) Abstract
 
 
ALX-400-019 Revised 27-Oct-06
4-Amino-TEMPO, free radical
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SYNONYMS 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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ALX-400-019-M010   10 mg 15.00 USD Add To Cart
ALX-400-019-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C9H19N2O
MW: 171.3
CAS NUMBER: 14691-88-4
PURITY: ≥97%
APPEARANCE: Orange to red solid or liquid.
SOLUBILITY: Soluble in methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Packaged under inert gas.
HAZARD: IRRITANT.

Product Description
Free radical compound.
 
 
ALX-440-046 Revised 07-Sep-06
4-Amino-(6R)-5,6,7,8-tetrahydro-L-biopterin . dihydrochloride
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SYNONYMS 4-Amino-(6R)-BH4 . 2HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-440-046-M005   5 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C9H16N6O2 . 2HCl
MW: 240.3 . 73.0
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for several years when stored at -20°C.
Sensitive to oxidation, especially in neutral and alkaline solutions. Solutions must be stored at -20°C or colder immediately after preparation. Use oxygen free water with the lowest possible pH. Ascorbic acid, DTT or other antioxidants may be added in order to increase stability.

Product Description
Potent, reversible inhibitor of nitric oxide synthases (NOS) at their pterin-site. Inhibits the formation of nitric oxide (NO) by nNOS (NOS I) with IC50=1.1µM for arginine (Prod. No. ALX-101-004) and IC50=1.3µM for NG-hydroxy-L-arginine (Prod. No. ALX-106-004). Prolongs allograft survival in vivo and rescues rats from septic shock. Immunosuppressant.
Product Specific Literature References
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin: B. Mayer, et al.; Biochemistry 36, 8422 (1997) Abstract
Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-aminotetrahydrobiopterin: S. Pfeiffer, et al.; Biochem. J. 328, 349 (1997) Abstract; Full Text
Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin: K. Schmidt, et al.; Eur. J. Biochem. 259, 25 (1999) Abstract; Full Text
Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue: S. Bahrami, et al.; Shock 13, 386 (2000) Abstract
Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin: H.D. Gibraeil, et al.; Br. J. Pharmacol. 131, 1757 (2000) Abstract
The 4-amino analogue of tetrahydrobiopterin efficiently prolongs murine cardiac-allograft survival: G. Brandacher, et al.; J. Heart Lung Transplant. 20, 747 (2001) Abstract
A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats: F. Fitzal, et al.; Shock 18, 158 (2002) Abstract
Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action: E.R. Werner and G. Werner-Felmayer; Curr. Drug Metab. 3, 119 (2002), (Review) Abstract
Single-turnover of nitric-oxide synthase in the presence of 4-amino-tetrahydrobiopterin: proposed role for tetrahydrobiopterin as a proton donor: M. Sorlie, et al.; J. Biol. Chem. 278, 48602 (2003) Abstract; Full Text
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity: A.R. Hurshman, et al.; Biochemistry 42, 13287 (2003) Abstract
CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin: S. Marchal, et al.; J. Inorg. Biochem. 98, 1217 (2004) Abstract
Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide: G. Thoeni, et al.; Free Radic. Biol. Med. 37, 375 (2004) Abstract
Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase: G. Thoeni, et al.; J. Immunol. 174, 7584 (2005) Abstract; Full Text
Further Categories Containing This Product:
Immunomodulators Other Products
 
 
ALX-270-033 Revised 13-Jul-07
AMT . hydrochloride
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SYNONYMS 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine . HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-033-M010   10 mg 90.00 USD Add To Cart
ALX-270-033-M050   50 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C5H10N2S . HCl
MW: 130.2 . 36.5
CAS NUMBER: 1121-91-1
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Potent and selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II).
Product Specific Literature References
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol. 47, 831 (1995) Abstract
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors: W.R. Tracey, et al.; Can. J. Physiol. Pharmacol. 73, 665 (1995) Abstract
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus: R.L. Rairigh, et al.; J. Clin. Invest. 101, 15 (1998) Abstract
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats: A.M. Briones, et al.; Br. J. Pharmacol. 126, 111 (1999) Abstract
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition: M.A. Rudd, et al.; Am. J. Physiol. 277, H732 (1999) Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Abstract; Full Text
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy: B.T. Alexander, et al.; Hypertension 39, 586 (2002) Abstract
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats: P. Clement, et al.; Neuroscience 135, 347 (2005) Abstract
 
 
ALX-430-126 Revised 18-Jul-08
Angeli's Salt
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SYNONYMS Hyponitric acid . disodium salt
Sodium α-oxyhyponitrite
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
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ALX-430-126-M010   10 mg 82.00 USD Add To Cart
Product Specification
FORMULA: N2O3 . 2Na
MW: 76.0 . 46.0
CAS NUMBER: 13826-64-7
PURITY: ≥99%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Highly soluble in water; also soluble in 0.01M sodium hydroxide.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Alkaline solutions (in 0.01M NaOH) are stable and can be stored at 0°C for one day. The half-life in 0.1M PBS, pH 7.4 is 2.3 min. at 37°C. The decomposition at pH 5 is nearly instantaneous.
HANDLING: Protect from light, oxygen and moisture.

Product Description
Nitric oxide (NO) donor. The stoichiometry of NO release is 0.54 mole per mole of Angeli’s Salt. The EC50 for relaxation of norepinephrine-constricted rabbit aorta is 0.59µM.
Product Specific Literature References
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991) Abstract
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO: J.M. Fukuto, et al.; BBRC 196, 707 (1993) Abstract
Angeli’s salt and spinal motor neuron injury: A.J. Vaananen, et al.; Free Radic. Res. 38, 271 (2004) Abstract
Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors: E. Cheong, et al.; Cell. Calcium 37, 87 (2005) Abstract
Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance: S.J. Hewett, et al.; Free Radic. Biol. Med. 39, 1478 (2005) Abstract
Mechanism of aerobic decomposition of Angeli’s salt (sodium trioxodinitrate) at physiological pH: K.M. Miranda, et al.; JACS 127, 722 (2005) Abstract
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo: K.M. Miranda, et al.; J. Med. Chem. 48, 8220 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To initiate the release of nitric oxide, add the alkaline solution of Angeli’s Salt to an excess of pH 7.0-7.4 buffer.
 
 
ALX-620-075 Revised 25-Sep-08
APF
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SYNONYMS Aminophenyl fluorescein
2-[6-(4'-Amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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