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ALX-550-095 Revised 02-May-06
Tamoxifen . citrate
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SYNONYMS (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine . citrate
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Hormone-related)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-095-G001   1 g 85.00 USD Add To Cart
Product Specification
FORMULA: C26H29NO . C6H8O7
MW: 371.5 . 192.1
CAS NUMBER: 54965-24-1
MERCK INDEX: 14: 9048
RTECS: KH2387000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol; very slightly soluble in water or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description
Antiestrogen. Selective protein kinase C (PKC) inhibitor. Induces apoptosis.
Product Specific Literature References
Inhibition of protein kinase C by tamoxifen: C.A. O'Brian, et al.; Cancer Res. 45, 2462 (1985) Abstract
Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells: M. Issandou, et al.; Cancer Res. 50, 5845 (1990) Abstract
Signalling targets for anticancer drug development: G. Powis; TIPS 12, 188 (1991), (Review) Abstract
Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines: W.T. Couldwell, et al.; FEBS Lett. 345, 43 (1994) Abstract
Tamoxifen: teaching an old drug new tricks?: D.J. Grainge & J.C. Metcalfe; Nat. Med. 2, 381 (1996), (Review) Abstract
Genomic effects of tamoxifen: J.A. Kellen; Anticancer Res. 16, 3537 (1996) Abstract
Steroidal and nonsteroidal oestrogen antagonists in breast cancer: basic and clinical appraisal: R.E. Favoni & A. de Cupis; TIPS 19, 406 (1998), (Review) Abstract
Recent advances in understanding the molecular mechanisms of tamoxifen action: Z.Y. Friedman; Cancer Invest. 16, 391 (1998) Abstract
Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells: M. Maccarrone, et al.; FEBS Lett. 434, 421 (1998) Abstract
Tamoxifen in the treatment of metastatic malignant melanoma: still a controversy? (Review): S. Toma, et al.; Int. J. Oncol. 15, 321 (1999) Abstract
Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes: D.A. Cameron, et al.; Eur. J. Cancer. 36, 845 (2000) Abstract
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells: S. Mandlekar, et al.; Cancer Res. 60, 5995 (2000) Abstract; Full Text
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines: S. Mandlekar, et al.; Cancer Res. 60, 6601 (2000) Abstract; Full Text
Update on clinical role of tamoxifen: J.R. Benson and V. Pitsinis; Curr. Opin. Obstet. Gynecol. 15, 13 (2003) Abstract
Tamoxifen for prevention of breast cancer: R.J. Cersosimo; Ann. Pharmacother. 37, 268 (2003) Abstract
Tamoxifen: a most unlikely pioneering medicine: V.C. Jordan; Nat. Rev. Drug Discov. 2, 205 (2003) Abstract
Is tamoxifen the Rosetta stone for breast cancer?: V.C. Jordan; J. Natl. Cancer Inst. 95, 338 (2003) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Estrogen & Estrogen Receptors / Related Products • Apoptosis Inducers & Inhibitors Other Products • MDR Inhibitors • Autophagy Other Products
 
 
ALX-550-361 Revised 18-Dec-07
(Z)-4-Hydroxytamoxifen
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SYNONYMS (Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Hormone-related)
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ALX-550-361-M001   1 mg 40.00 USD Add To Cart
ALX-550-361-M005   5 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C26H29NO2
MW: 387.5
CAS NUMBER: 68047-06-3, 65213-48-1
PURITY: ≥98% (Z-isomer)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description
Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.
Product Specific Literature References
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990) Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990) Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993) Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994) Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999) Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Estrogen & Estrogen Receptors / Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-170-001 Revised 16-Dec-03
Vasoactive Intestinal Contractor (mouse)
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SYNONYMS VIC (mouse)
β-Endothelin (mouse)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-170-001-PC01   0.1 mg* 70.00 USD Add To Cart
ALX-170-001-PC05   0.5 mg* 210.00 USD Add To Cart
ALX-170-001-P001   1 mg* 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Asn-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
FORMULA: C116H161N27O32S4
MW: 2574.0
CAS NUMBER: 120928-04-3
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Differential activities of two distinct endothelin family peptides on ileum and coronary artery: N. Ishida, et al.; FEBS Lett. 247, 337 (1989) Abstract
A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity: K. Saida, et al.; J. Biol. Chem. 264, 14613 (1989) Abstract; Full Text
Cellular signaling by peptides of the endothelin gene family: M.S. Simonson & M.J. Dunn; FASEB J. 4, 2989 (1990) Abstract
Further Categories Containing This Product:
Peptides • Hormones & Hormone Receptors Other Products
 
 
ALX-460-025 Revised 25-Mar-08
Vitamin D2
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SYNONYMS Calciferol
Ergocalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-025-G001   1 g 33.00 USD Add To Cart
ALX-460-025-G005   5 g 135.00 USD Add To Cart
Product Specification
FORMULA: C28H44O
MW: 396.7
CAS NUMBER: 50-14-6
MERCK INDEX: 14: 10018
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Oxidized and inactivated by moisture within a few days.
HANDLING: Protect from light and moisture. Keep under inert gas.

Further Categories Containing This Product:
Vitamins
 
 
ALX-460-026 Revised 25-Mar-08
Vitamin D3
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SYNONYMS Cholecalciferol
Colecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-026-G001   1 g 23.00 USD Add To Cart
ALX-460-026-G005   5 g 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O
MW: 384.7
CAS NUMBER: 67-97-0
MERCK INDEX: 14: 10019
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Oxidized and inactivated by moisture within a few days.
HANDLING: Keep under inert gas. Protect from light and moisture.

Further Categories Containing This Product:
Vitamins
 
 
ALX-350-280 Revised 07-Oct-08
Xanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-280-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
CAS NUMBER: 569-83-5, 6754-58-1
SOURCE/HOST: Isolated from hops (Humulus lupulus).
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY: Identity determined by NMR.

Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors / Related Products • Cell Differentiation • Hypoxia-inducible Factor [HIF] / Related Products • Chalcones • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Respiratory Chain Other Products • Obesity & Diabetes Other Products • Natural Products - Antitumor Reagents • VEGFs • Lipid Metabolism Other Products
 
 
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