• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Chemokines & Chemokine Receptors / Related Products
You are here: Product Lines > Chemokines & Cytokines > Chemokines & Chemokine Receptors / Related Products
 
Toolbar - View Selection
 
 Items 1-20 of 42 Page 1 of 3 Select Page: 1 2 3  >>  
ALX-350-335 Revised 14-Nov-07
Cochlioquinone A
Add to Clipboard
SYNONYMS Luteoleersin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-335-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C30H44O8
MW: 532.7
CAS NUMBER: 32450-25-2
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites: J.M. Schaeffer, et al.; J. Antibiot. (Tokyo) 43, 1179 (1990) Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi: T. Fujioka, et al.; J. Antibiot. (Tokyo) 49, 409 (1996) Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola: H.J. Jung, et al.; Bioorg. Med. Chem. 11, 4743 (2003) Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1: H.B. Lee, et al.; J. Antibiot. (Tokyo) 56, 967 (2003) Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • NAD+ Metabolism / Related Products • Vitamins
 
 
ALX-350-341 Revised 14-Nov-07
Cochlioquinone B
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-341-MC05   0.5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C28H40O6
MW: 472.6
CAS NUMBER: 32450-26-3
SOURCE/HOST: Isolated from Bipolaris leersia MST-FP107.
PURITY: ≥99% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum: K. Yoganathan, et al.; J. Antibiot. (Tokyo) 57, 59 (2004) Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products • NAD+ Metabolism / Related Products • Vitamins
 
 
ALX-270-478 Revised 30-Jul-08
SB 225002
Add to Clipboard
SYNONYMS N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-478-M001   1 mg 30.00 USD Add To Cart
ALX-270-478-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C13H10BrN3O4
MW: 352.1
CAS NUMBER: 182498-32-4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR and 13C-NMR.

Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998) Abstract; Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003) Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006) Abstract; Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
 
 
ALX-201-388 Revised 08-Oct-08
CX3CL1, Soluble  (human) (recombinant)
Add to Clipboard
SYNONYMS Fractalkine, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CX3C Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-388-C010   10 µg 170.00 USD Add To Cart
ALX-201-388-C050   50 µg 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of human CX3CL1 (fractalkine) (aa 1-339) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY: Chemotaxis effect of soluble recombinant human CX3CL1 (fractalkine) in THP-1 cells (see Figure 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P78423: Fractalkine (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-804-465 Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (5D3-F7)
Add to Clipboard
SYNONYMS anti-MCP-1 (human) MAb (5D3-F7)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5D3-F7)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-465-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 5D3-F7
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY: Recognizes human CCL2.
APPLICATION: ELISA (capture)
Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections, paraffin sections (1:250-1:500))
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A new monoclonal antibody (5D3-F7) which recognizes human monocyte chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells: G. Peri, et al.; J. Immunol. Methods 174, 249 (1994) Abstract
Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes: M. Locati, et al.; J. Immunol. 168, 3557 (2002) Full Text
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation: L. Piemonti, et al.; Diabetes 51, 55 (2002) Full Text
Further Categories Containing This Product:
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products • Monoclonal Antibodies
 
 
ALX-804-469 Revised 07-May-08
Monoclonal Antibody to CCL22 (human) (349/6)
Add to Clipboard
SYNONYMS anti-MDC (human) MAb (349/6)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-469-C250   250 µg 540.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 349/6
ISOTYPE: Rat IgG
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY: Recognizes human CCL22.
APPLICATION: ELISA (capture (20µg/ml))
Use microtiter plates coated with this antibody in 0.05M carbonate/bicarbonate buffer, pH 9.6, in combination with secondary antibody (Prod. No. ALX-804-470, MAb to CCL22 (human) (152/11)) at 1-2µg/ml to detect human MDC.
Detection Limit: ~40pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Preservative may be added for storage at +4°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-470 Revised 10-May-06
Monoclonal Antibody to CCL22 (human) (152/11)
Add to Clipboard
SYNONYMS anti-MDC (human) MAb (152/11)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-470-C250   250 µg 540.00 USD Add To Cart
ALX-804-470E-C250 Peroxidase 250 µg 580.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 152/11
ISOTYPE: Rat IgG
CONCENTRATION: ALX-804-470: 2.3mg/ml
ALX-804-470E:  0.36mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: ALX-804-470: Liquid. In PBS, pH 7.4.
ALX-804-470E: Liquid. In PBS, pH 7.4, containing 0.2% bronidox and 0.05% phenol.
IMMUNOGEN: Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY: Recognizes human CCL22.
APPLICATION: ALX-804-470: Western Blot (2-4µg/ml)
Detection Limit: 0.2µg/lane.
ALX-804-470E: ELISA (detection (1-2µ/ml))
Use microtiter plates coated with primary antibody (Prod. No. ALX-804-469, MAb to CCL22 (human) (349/6) at 20µg/ml in 0.05M carbonate/bicarbonate buffer, pH 9.6) to detect human fractalkine.
Detection Limit: ~60pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
SHIPPING: SHIPPED ON BLUE ICE
USE/STABILITY: ALX-804-470: Short Term Storage: +4°C. Long Term Storage: After opening, prepare aliquots and store at -20°C.
ALX-804-470E: Long Term Storage: +4°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-489 Revised 02-Jun-05
Monoclonal Antibody to CCL1 (human) (8P16-N4-L21)
Add to Clipboard
SYNONYMS anti-I-309 (human) MAb (8P16-N4-L21)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-489-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 8P16-N4-L21
ISOTYPE: Mouse IgM
CONCENTRATION: 1mg/ml
PURITY DETAIL: DEAE purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Recombinant human CCL1 (I-309).
SPECIFICITY: Recognizes human CCL1.
APPLICATION: Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-549 Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (D9)
Add to Clipboard
SYNONYMS anti-MCP-1 (human) MAb (D9)
anti-Monocyte Chemotactic Protein-1 (human) MAb (D9)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-549-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: D9
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein G purified antibody in PBS.
IMMUNOGEN: Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY: Recognizes human CCL2.
APPLICATION: Immunoprecipitation
Western Blot (5µg/ml)
Functional Application (blocks CCL2 [MCP-1]; 2µg/ml)
Not recommended for immunohistochemistry.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-591 Revised 20-Nov-06
Monoclonal Antibody to CCR3 (human) (5E8)
Add to Clipboard
SYNONYMS anti-C-C Chemokine Receptor 3 (human) MAb (5E8)
anti-Eotaxin Receptor (human) MAb (5E8)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-591-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 5E8
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: L1.2 cells expressing human CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY: Recognizes human CCR3.
APPLICATION: Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-594 Revised 10-Jun-05
Monoclonal Antibody to CCL2 (human) (5J.1)
Add to Clipboard
SYNONYMS anti-MCP-1 (human) MAb (5J.1)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5J.1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-594-C100   100 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 5J.1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY: Recognizes human CCL2.
APPLICATION: Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-471 Revised 05-Aug-05
Monoclonal Antibody to CX3CL1 (human) (28/31)