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ALX-270-052
Revised 05-Oct-06
Bisindolylmaleimide IV
SYNONYMS
Ro 31-6233
Arcyriarubin A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-052-M001
1 mg
45.00 USD
ALX-270-052-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
20
H
13
N
3
O
2
MW:
327.3
CAS NUMBER:
119139-23-0
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Specific Literature References
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds:
S. Fabre & M. Prudhomme; Bioorg. Med. Chem.
1
, 193 (1993)
Abstract
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides:
P.D. Davis, et al.; J. Med. Chem.
35
, 177 (1992)
Abstract
ALX-270-053
Revised 29-Jul-05
Bisindolylmaleimide V
SYNONYMS
Ro 31-6045
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Negative Controls
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-053-M001
1 mg
45.00 USD
ALX-270-053-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
21
H
15
N
3
O
2
MW:
341.4
CAS NUMBER:
113963-68-1
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO or methanol; very slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Negative control for the protein kinase C (PKC)-inhibitory activity.
Product Specific Literature References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C:
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides:
P.D. Davis, et al.; J. Med. Chem.
35
, 177 (1992)
Abstract
ALX-270-054
Revised 07-Dec-04
Bisindolylmaleimide VI
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-054-M001
1 mg
45.00 USD
ALX-270-054-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
26
N
4
O
2
MW:
438.5
PURITY:
≥96% (mixture of 2 isomers)
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-055
Revised 07-Dec-04
Bisindolylmaleimide VII
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
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ALX-270-055-M001
1 mg
45.00 USD
ALX-270-055-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
27
N
5
O
2
MW:
453.5
CAS NUMBER:
137592-47-3
PURITY:
≥96%
APPEARANCE:
Orange solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-056
Revised 18-Jan-08
Bisindolylmaleimide VIII . acetate
SYNONYMS
Ro 31-7549 . acetate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
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Format:
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ALX-270-056-M001
1 mg
45.00 USD
ALX-270-056-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
24
H
22
N
4
O
2
. CH
3
COOH
MW:
398.5 . 60.1
CAS NUMBER:
138516-31-1
PURITY:
≥98%
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Specific Literature References
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
:
T. Zhou, et al.; Nat. Med.
5
, 42 (1999)
Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways
:
T. Ohtsuka & T. Zhou; J. Biol. Chem.
277
, 29294 (2002)
Abstract
;
Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-020
Revised 07-Dec-04
Bisindolylmaleimide IX . methanesulfonate
SYNONYMS
Ro 31-8220 . methanesulfonate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
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ALX-270-020-M001
1 mg
45.00 USD
ALX-270-020-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
25
H
23
N
5
O
2
S . CH
4
O
3
S
MW:
457.6 . 96.1
CAS NUMBER:
138489-18-6
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors:
T.E. Harris, et al.; BBRC
227
, 672 (1996)
Abstract
ALX-270-057
Revised 18-Jan-08
Bisindolylmaleimide X . hydrochloride
SYNONYMS
Ro 31-8425 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-057-M001
1 mg
45.00 USD
ALX-270-057-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
26
H
24
N
4
O
2
. HCl
MW:
424.5 . 36.5
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-058
Revised 28-May-08
Bisindolylmaleimide XI . hydrochloride
SYNONYMS
Ro 32-0432 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-058-M001
1 mg
45.00 USD
ALX-270-058-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
28
H
28
N
4
O
2
. HCl
MW:
452.6 . 36.5
PURITY:
≥98% (NMR)
APPEARANCE:
Orange to brown red solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-487
Revised 16-Sep-08
BML-259
SYNONYMS
N-(5-Isopropylthiazol-2-yl)phenylacetamide
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-487-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
14
H
16
N
2
OS
MW:
260.4
CAS NUMBER:
267654-00-2
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
30mg/ml soluble in DMSO or dimethyl formamide, 0.25mg/ml soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
Product Description
Potent inhibitor of CDK5 (IC
50
= 64nM) and CDK2 / cyclin E (IC
50
= 98nM).
Product Specific Literature References
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease:
C.J. Helal, et al.; Bioorg. Med. Chem. Lett.
14
, 5521 (2004)
Abstract
ALX-270-390
Revised 09-Jan-08
Bohemine
SYNONYMS
6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-390-M001
1 mg
40.00 USD
ALX-270-390-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
18
H
24
N
6
O
MW:
340.4
CAS NUMBER:
189232-42-6
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
Product Description
Cell permeable inhibitor of CDK1 (IC
50
=1.1µM) and CD2 (IC
50
=600nM). Arrests cell cycle in the G
1
/S boundary and activates mature bovine oocytes.
Product Specific Literature References
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds
:
L. Havlicek, et al.; J. Med. Chem.
40
, 408 (1997)
Abstract
Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation
:
P. Binarova, et al.; Plant J.
16
, 697 (1998)
Abstract
Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases
:
R. Alberio, et al.; Mol. Reprod. Dev.
55
, 422 (2000)
Abstract
Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine
:
H. Kovarova, et al.; Electrophoresis
21
, 3757 (2000)
Abstract
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route
:
Z. Chmela, et al.; Drug. Metab. Dispos.
29
, 326 (2001)
Abstract
;
Full Text
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases:
K. Vermeulen, et al.; Leukemia
16
, 299 (2002)
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products
ALX-201-204/1
Revised 06-Jun-08
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
SYNONYMS
proBMP-2 (human) (recombinant)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
Ordering Information
