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ALX-550-016
Revised 08-Nov-07
(S)-AMPA
SYNONYMS
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-016-M005
5 mg
95.00 USD
ALX-550-016-M025
25 mg
380.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
83643-88-3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Active enantiomer of (R,S)-AMPA (Prod. No.
ALX-550-023
).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid:
J.J. Hansen, et al.; J. Med. Chem.
26
, 901 (1983)
Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors:
J. Lauridsen, et al.; J. Med. Chem.
28
, 668 (1985)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-550-023
Revised 04-Apr-08
(R,S)-AMPA
SYNONYMS
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-023-M005
5 mg
65.00 USD
ALX-550-023-M025
25 mg
260.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
74341-63-2
PURITY:
≥97% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Potent and selective quisqualate analog that interacts with the AMPA subgroup of ionotropic glutamate receptors.
Product Specific Literature References
New class of glutamate agonist structurally related to ibotenic acid:
P. Krogsgaard-Larsen, et al.; Nature
284
, 64 (1980)
Abstract
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes:
T. Honoré, et al.; J. Neurochem.
38
, 173 (1982)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-350-106
Revised 29-Nov-07
Ampullosporin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-350-106-M001
1 mg
50.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA:
C
77
H
127
N
19
O
19
MW:
1623.0
SOURCE/HOST:
Antibiotic isolated from
Sepedonium ampullosporum
.
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Peptaibol-type polypeptide. Induces pigment formation by the fungus
Phoma destructiva
, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.
Product Specific Literature References
Ampullosporin, a new peptaibol-type antibiotic from
Sepedonium ampullosporum
HKI-0053 with neuroleptic activity in mice:
M. Ritzau, et al.; J. Antibiot.
50
, 722 (1997)
Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics:
P. Grigoriev, et al.; Bioelectrochemistry
44
, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A:
P. Grigoriev, et al.; Bioelectrochemistry
57
, 119 (2002)
Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A:
H.H. Nguyen, et al.; J. Med. Chem.
45
, 2781 (2002)
Abstract
Crystal structure and conformational analysis of ampullosporin A:
M. Kronen, et al.; J. Pept. Sci.
9
, 729 (2003)
Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I:
T.N. Kropacheva, et al.; Biochim. Biophys. Acta
1715
, 6 (2005)
Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model:
H. Krugel, et al.; J. Neurochem.
97, Suppl. 1
, 74 (2006)
Abstract
Further Categories Containing This Product:
Peptides
•
Alzheimer Research Other Products
•
Ion Channels & Transporters Other Products
ALX-151-011
Revised 13-Jan-05
β-Amyloid/A4 Protein Precursor [APP] (328-332)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-151-011-P001
1 mg*
90.00 USD
ALX-151-011-P005
5 mg*
360.00 USD
Product Specification
SEQUENCE:
H-Arg-Glu-Arg-Met-Ser-OH
FORMULA:
C
25
H
47
N
11
O
9
S
MW:
677.8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in TFA/water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Active domain of the amyloid β/A4 protein precursor (APP) that promotes fibroblast growth.
Product Specific Literature References
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth:
H. Ninomiya, et al.; J. Cell. Biol.
121
, 879 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-005
Revised 25-Nov-04
β-Amyloid (1-28)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-005-PC05
0.5 mg*
160.00 USD
ALX-151-005-P001
1 mg*
270.00 USD
Product Specification
SEQUENCE:
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
FORMULA:
C
145
H
209
N
41
O
46
MW:
3262.5
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor:
J. Kang, et al.; Nature
325
, 733 (1987)
Abstract
Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro:
D.A. Kirschner, et al.; PNAS
84
, 6953 (1987)
Abstract
Brain protein yields clues to Alzheimer's disease:
J.L. Marx; Science
243
, 1664 (1989)
Abstract
Is amyloid deposition in Alzheimer's disease preceded by an environment- induced double conformational transition?:
M. Hollosi, et al.; Pept. Res.
2
, 109 (1989)
Abstract
Amyloid beta protein enhances the survival of hippocampal neurons in vitro:
J.S. Whitson, et al.; Science
243
, 1488 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-003
Revised 25-Nov-04
β-Amyloid (1-40)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-003-PC05
0.5 mg*
290.00 USD
ALX-151-003-P001
1 mg*
560.00 USD
Product Specification
SEQUENCE:
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
FORMULA:
C
194
H
295
N
53
O
58
S
MW:
4329.9
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides:
B.A. Yankner, et al.; Science
250
, 279 (1990)
Abstract
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease:
J.T. Jarrett, et al.; Biochemistry
32
, 4693 (1993)
Abstract
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease:
H. Sticht, et al.; Eur. J. Biochem.
233
, 293 (1995)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-002
Revised 07-Mar-05
β-Amyloid (1-42)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-002-PC05
0.5 mg*
350.00 USD
ALX-151-002-P001
1 mg*
620.00 USD
Product Specification
SEQUENCE:
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
FORMULA:
C
203
H
311
N
55
O
60
S
MW:
4514.1
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in 5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease:
D. Goldgaber, et al.; Science
235
, 877 (1987)
Abstract
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor:
J. Kang, et al.; Nature
325
, 733 (1987)
Abstract
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease:
J. Murrell, et al.; Science
254
, 97 (1991)
Abstract
Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition:
C.J. Barrow & M.G. Zagorski; Science
253
, 179 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-001
Revised 25-Nov-04
β-Amyloid (1-43)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-001-PC01
0.1 mg*
120.00 USD
ALX-151-001-PC05
0.5 mg*
480.00 USD
Product Specification
SEQUENCE:
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr-OH
FORMULA:
C
207
H
318
N
56
O
62
S
MW:
4615.3
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease:
D. Goldgaber, et al.; Science
235
, 877 (1987)
Abstract
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor:
J. Kang, et al.; Nature
325
, 733 (1987)
Abstract
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state:
C.J. Pike, et al.; J. Neurosci.
13
, 1676 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-009
Revised 13-Aug-02
β-Amyloid (10-20)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-009-P001
1 mg*
90.00 USD
ALX-151-009-P005
5 mg*
360.00 USD
Product Specification
SEQUENCE:
H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH
FORMULA:
C
71
H
99
N
17
O
16
MW:
1446.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor:
K. Miyazaki, et al.; Nature
362
, 839 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-008
Revised 23-Oct-07
β-Amyloid (25-35)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-008-P001
1 mg*
120.00 USD
ALX-151-008-P005
5 mg*
480.00 USD
Product Specification
SEQUENCE:
H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
FORMULA:
C
45
H
81
N
13
O
14
S
MW:
1060.3
QUANTITY:
*Sold as net peptide weight.
PEPTIDE CONTENT:
70-90%
PURITY:
≥99% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides:
B.A. Yankner, et al.; Science
250
, 279 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-007
Revised 14-Dec-04
[Gln11]-β-Amyloid (1-16)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
beta-Amyloid Peptides
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-007-PC05
0.5 mg*
120.00 USD
ALX-151-007-P001
1 mg*
190.00 USD
Product Specification
SEQUENCE:
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-OH
FORMULA:
C
84
H
119
N
27
O
28
MW:
1955.0
CAS NUMBER:
133605-53-5
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
