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NMDA Receptors / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Ionotropic) / Related Products > NMDA Receptors / Related Products
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ALX-101-010 Revised 11-Sep-07
L-Aspartic acid
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SYNONYMS H-L-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-010-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 56-84-8
MERCK INDEX: 14: 840
RTECS: CI9098500
PURITY: ≥99.5%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-101-011 Revised 22-Nov-06
D-Aspartic acid
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SYNONYMS H-D-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-011-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 1783-96-6
MERCK INDEX: 14: 840
RTECS: CI9097500
PURITY: ≥99%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
ALX-105-009 Revised 06-Jun-06
N-Methyl-D-aspartic acid
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SYNONYMS NMDA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010   10 mg 23.00 USD Add To Cart
ALX-105-009-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 6384-92-5
MERCK INDEX: 14: 6662
RTECS: CI9457000
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters: J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
NMDA receptors and ligands in the vertebrate CNS: T.W. Stone & N.R. Burton; Progr. Neurobiol. 30, 333 (1988), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Special Amino Acids
 
 
ALX-106-024 Revised 14-Oct-08
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-106-028 Revised 03-Apr-08
D-Cycloserine
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SYNONYMS R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-028-M050   50 mg 20.00 USD Add To Cart
ALX-106-028-M250   250 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 68-41-7
RTECS: NY2975000
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids • Special Amino Acids • NMDA Receptors / Related Products
 
 
ALX-106-037 Revised 09-Oct-07
L-Cycloserine
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SYNONYMS S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-037-M025   25 mg 50.00 USD Add To Cart
ALX-106-037-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 339-72-0; 4834-58-6
MERCK INDEX: 14: 2751
RTECS: NY2976000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem. 42, 577 (1984) Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res. 28, 1478 (1987) Abstract; Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res. 510, 158 (1990) Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res. 565, 345 (1991) Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Further Categories Containing This Product:
Special Amino Acids • Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NAALADase / Related Products • Peptides
 
 
ALX-210-266 Revised 22-Aug-05
Polyclonal Antibody to PSD-93 (rat)
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SYNONYMS anti-Post-synaptic Density 93kDa Protein (rat) PAb
anti-Chapsyn-110 (rat) PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-210-266-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 352-366 (N352KLCDKPASPR
HYSP366) of rat PSD-93 (post-synaptic density 93kDa protein).
SPECIFICITY: Recognizes rat PSD-93. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (5µg/ml))
Western Blot (3µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-045.
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Further Categories Containing This Product:
Synaptic Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-270-121 Revised 01-Dec-04
N-(3-Aminopropyl)cyclohexylamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-270-121-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C9H20N2
MW: 156.3
CAS NUMBER: 3312-60-5
PURITY: ≥97% (contains traces of water)
APPEARANCE: Pale yellow clear liquid. d = 0.920.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Competitive inhibitor of spermine and spermidine synthases.
Product Specific Literature References
Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors: A. Shirahata, et al.; Biochem. Pharmacol. 41, 205 (1991) Abstract
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo: P.J. Chu, et al.; Eur. J. Pharmacol. 256, 155 (1994) Abstract
 
 
ALX-550-001 Revised 20-Jun-07
Agmatine . sulfate
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SYNONYMS 1-Amino-4-guanidinobutane . sulfate
4-(Aminobutyl)guanidine . sulfate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Imidazoline Binding Site Ligands
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ALX-550-001-M100   100 mg 22.00 USD Add To Cart
ALX-550-001-M500   500 mg 44.00 USD Add To Cart
Product Specification
FORMULA: C5H14N4 . H2SO4
MW: 130.2 . 98.1
CAS NUMBER: 2482-00-0
MERCK INDEX: 14: 188
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Decarboxylation product of L-arginine. Endogenous clonidine-displacing substance in the brain. Putative endogenous neurotransmitter at imidazoline receptors. Antagonist of NMDA receptor. Endogenous inhibitor of nitric oxide synthase (NOS). Antiproliferative by its suppresive effect on polyamine.
Product Specific Literature References
Agmatine: an endogenous clonidine-displacing substance in the brain: G. Li, et al.; Science 263, 966 (1994) Abstract
Selective inhibition of inducible nitric oxide synthase by agmatine: M. Auguet, et al.; Jpn. J. Pharmacol. 69, 285 (1995) Abstract
Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine: E. Galea, et al.; Biochem. J. 316, 247 (1996) Abstract; Full Text
An emerging role for agmatine: J. Satriano, et al.; Kidney Int. 56, 1252 (1999), (Review) Abstract
Is agmatine a novel neurotransmitter in brain?: D.J. Reis & S. Regunathan; Trends Pharmacol. Sci. 21, 187 (2000) Abstract
Agmatine suppresses nitric oxide production in microglia: K. Abe, et al.; Brain Res. 872, 141 (2000) Abstract
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme: D.R. Demady, et al.; Mol. Pharmacol. 59, 24 (2001) Abstract; Full Text
Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes: S. Regunathan & J.E. Piletz; Ann. N. Y. Acad. Sci. 1009, 20 (2003) Abstract
Agmatine: at the crossroads of the arginine pathways: J. Satriano; Ann. N. Y. Acad. Sci. 1009, 34 (2003), (Review) Abstract
Agmatine signaling: odds and threads: R. Berkels, et al.; Cardiovasc. Drug Rev. 22, 7 (2004), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-550-003 Revised 13-Oct-05
Spermine . tetrahydrochloride
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SYNONYMS N,N'-bis[3-Aminopropyl]-1,4-butanediamine . 4HCl
PRODUCT LINE