• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
You are here: Product Lines > Cytoskeleton > Blood Coagulation & Fibrinolysis > Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
Toolbar - View Selection
 
Items 20 of 20
ALX-430-115 Revised 14-Aug-08
Aspirin
Add to Clipboard
SYNONYMS Acetylsalicylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-115-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C9H8O4
MW: 180.2
CAS NUMBER: 50-78-2
MERCK INDEX: 14: 851
RTECS: VO0700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 2 years when stored at room temperature. Keep aqueous solutions on ice and use within 30 minutes. Unstable in basic solutions pH>7.4.
HAZARD: HARMFUL.

Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin: E. Kopp & S. Ghosh; Science 265, 956 (1994) Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation: M. Grilli, et al.; Science 274, 1383 (1996) Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta: M.J. Yin, et al.; Nature 396, 77 (1998) Abstract
The pleiotropic functions of aspirin: mechanisms of action: A.R. Amin, et al.; Cell Mol. Life Sci. 56, 305 (1999) Abstract
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-350-226 Revised 22-Sep-08
Caffeic acid methyl ester
Add to Clipboard
SYNONYMS Methyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-226-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H10O4
MW: 194.2
CAS NUMBER: 3843-74-1
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Slightly yellowish solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Inhibitor of ornithine decarboxylase and protein tyrosine kinases. Has a strong inhibitory effect on human platelet aggregation. Shows antioxidant, antiproliferative and cytotoxic properties.
Product Specific Literature References
Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth: C.V. Rao, et al.; Chem. Biol. Interactions 84, 277 (1992) Abstract
Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb: W.C. Chang & F.L. Hsu; Prostaglandins Leukot. Essent. Fatty Acids 45, 307 (1992) Abstract
Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell: I.R. Lee & M.Y. Yang; Arch. Pharm. Res. 17, 476 (1994) Abstract
Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata: M.K. Pyo, et al.; Arch. Pharm. Res. 25, 325 (2002) Abstract
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles: J.E. Burdette, et al.; J. Agric. Food Chem. 50, 7022 (2002) Abstract
Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids: S.M. Fiuza, et al.; Bioorg. Med. Chem. 12, 3581 (2004) Abstract
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Tyrosine Kinase Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Antioxidants • Antitumor Agents (Anti-proliferative) • Phenolic Acids
 
 
ALX-380-012 Revised 16-Jun-08
Cytochalasin B
Add to Clipboard
SYNONYMS Phomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-012-M001   1 mg 35.00 USD Add To Cart
ALX-380-012-M005   5 mg 90.00 USD Add To Cart
ALX-380-012-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C29H37NO5
MW: 479.6
CAS NUMBER: 14930-96-2
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Cell permeable mycotoxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Product Specific Literature References
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972) Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972) Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Review Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse, et al.; Cell Biochem. Funct. 5, 183 (1987) Abstract
Apoptosis induced by adenosine in human leukemia HL-60 cells: Y. Tanaka, et al.; Exp. Cell Res. 213, 242 (1994) Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos, et al.; Biochem. Pharmacol. 47, 1875 (1994) Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky, et al.; Life Sci. 66, 271 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Alkaloids • Actin / Related Products
 
 
ALX-350-124 Revised 05-Apr-08
Ferulenol
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-124-M001   1 mg 45.00 USD Add To Cart
ALX-350-124-M005   5 mg 135.00 USD Add To Cart
ALX-350-124-M010   10 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C24H30O3
MW: 366.5
CAS NUMBER: 6805-34-1
SOURCE/HOST: Isolated from Ferula communis.
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.
Product Specific Literature References
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Natural Products for Cell Cycle Research • Natural Products - Antitumor Reagents
 
 
ALX-430-004 Revised 13-Dec-06
GEA 3162
Add to Clipboard
SYNONYMS 1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide Donors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-004-M010   10 mg 65.00 USD Add To Cart
ALX-430-004-M050   50 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C7H4Cl2N4O . HCl
MW: 231.1 . 36.5
CAS NUMBER: 144575-47-3
PURITY: ≥97%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from oxygen. Use fresh solutions.

Product Description
Water soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). Stimulates cGMP production in platelets, granulocytes and polymorphonuclear leukocytes. Vasodepressant.
Product Specific Literature References
Scavenging of superoxide anions by nitric oxide donors: J. Robak, et al.; Pharmacol. Res. 25 S2, 355 (1992)
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions: E. Moilanen, et al.; Br. J. Pharmacol. 109, 852 (1993) Abstract
Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems: T. Corell, et al.; Pol. J. Pharmacol. 46, 553 (1994) Abstract
Mesoionic oxatriazole derivatives-a new group of NO-donors: G. Karup, et al.; Pol. J. Pharmacol. 46, 541 (1994) Abstract
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein: U. Malo-Ranta, et al.; FEBS Lett. 337, 179 (1994) Abstract
Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry: H.T. Ma, et al.; J. Biol. Chem. 274, 35318 (1999) Abstract; Full Text
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism: E.L. Taylor, et al.; Br. J. Pharmacol. 143, 179 (2004) Abstract
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants: Z. Sulowska, et al.; Mediators Inflamm. 2005, 81 (2005) Abstract; Full Text
GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation: M.F. Hsu, et al.; Eur. J. Pharmacol. 535, 43 (2006) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-301-009 Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine
Add to Clipboard
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-009-M005   5 mg 45.00 USD Add To Cart
ALX-301-009-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C30H62NO7P
MW: 579.8
CAS NUMBER: 99103-16-9
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in chloroform, 100% ethanol or methanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Product Description
PAF antagonist. Shows inhibitory behavior on platelet aggregation, secretion and phospholipid turnover.
Product Specific Literature References
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation: A. Tokumura, et al.; J. Biol. Chem. 260, 12710 (1985) Abstract; Full Text
Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages: M. Rouis, et al.; BBRC 156, 1293 (1988) Abstract
Further Categories Containing This Product:
Phospholipids / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
Add to Clipboard
SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antifungal Agents
 
 
ALX-350-352 Revised 06-Mar-08
Magnolol
Add to Clipboard
SYNONYMS 5,5’-Diallyl-2,2’-biphenyldiol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-352-M005   5 mg 55.00 USD Add To Cart
ALX-350-352-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 528-43-8
MERCK INDEX: 14: 5697
RTECS: DV5105500
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003) Abstract
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products for Neurological Research • NOS Inhibitors (NOS Induction & Enzyme Activity) • Anxiolytic Agents / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products with Antibiotic Activity • Natural Products - Nitric Oxide Pathway Modulators
 
 
ALX-270-083 Revised 05-Oct-06
Milrinone
Add to Clipboard
SYNONYMS 1,6-Dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-083-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C12H9N3O
MW: 211.2
CAS NUMBER: 78415-72-2
MERCK INDEX: 14: 6197
PURITY: ≥97%
APPEARANCE: Light red solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of phosphodiesterase 3 (PDE3).
Product Specific Literature References
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol. 29, 506 (1986) Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989)