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Obesity & Adipokines
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ALX-270-264 Revised 17-Apr-08
Carnosic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-264-M010   10 mg 45.00 USD Add To Cart
ALX-270-264-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C20H28O4
MW: 332.4
CAS NUMBER: 3650-09-7
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥95%
APPEARANCE: Yellow powder.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.
Product Specific Literature References
Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products with Antibiotic Activity • Natural Products - Anti-inflammatory Agents • PPAR Agonists
 
 
ALX-270-160 Revised 27-Sep-07
Castanospermine
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SYNONYMS (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-160-M010   10 mg 60.00 USD Add To Cart
ALX-270-160-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C8H15NO4
MW: 189.2
CAS NUMBER: 79831-76-8
MERCK INDEX: 14: 1896
SOURCE/HOST: Isolated from Castanospermum australe seeds.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.

Product Description
Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.
Product Specific Literature References
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin: Y.T. Pan, et al.; Biochemistry 22, 3975 (1983) Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications: H. Schachter; Clin. Biochem. 17, 3 (1984) Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles: R. Repp, et al.; J. Biol. Chem. 260, 15873 (1985) Abstract; Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates: M.R. Bartlett, et al.; Immunol. Cell Biol. 72, 367 (1994) Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2: S.P. Ahmed, et al.; BBRC 208, 267 (1995) Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth: R. Pili, et al.; Cancer Res. 55, 2920 (1995) Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells: C. Durrant & S.E. Moore; Biochem. J. 365, 239 (2002) Abstract
Further Categories Containing This Product:
Glycosidases / Related Products • Natural Products - Antiviral / anti-HIV Agents • Natural Products for Angiogenesis Research • Alkaloids
 
 
ALX-380-053 Revised 19-Jun-08
Cerulenin
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SYNONYMS 2,3-Epoxy-4-oxo-7,10-dodecadienamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-053-M005   5 mg 60.00 USD Add To Cart
ALX-380-053-M010   10 mg 110.00 USD Add To Cart
ALX-380-053-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C12H17NO3
MW: 223.3
CAS NUMBER: 17397-89-6
MERCK INDEX: 14: 2004
RTECS: JR1670000
SOURCE/HOST: Isolated from Cephalosporium caerulens.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, dichloromethane, methanol, 100% ethanol or acetone; slighly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).
Product Specific Literature References
Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin: Y. Sato, et al.; J. Antibiot. (Tokyo) 200, 344 (1967) Abstract
Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings: F. Schneider, et al.; Biochim. Biophys. Acta 1152, 243 (1993) Abstract
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene: J. Inokashi, et al.; Mol. Gen. Genet. 244, 90 (1994) Abstract
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting: H. Makimura, et al.; Diabetes 50, 733 (2001) Abstract; Full Text
Key role of mitochondria in cerulenin-mediated apoptosis: S.J. Heiligtag, et al.; Cell Death Differ. 9, 1017 (2002) Abstract
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells: T.S. Ho, et al.; Biomed. Pharmacother. 61, 578 (2007) Abstract
Further Categories Containing This Product:
Fatty Acid Synthase [FAS] / Related Products
 
 
APO-54N-040 Revised 05-Dec-08 New product
Chemerin (human) Detection Set [For ELISA Application]
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SYNONYMS RARRES2 (human) Detection Set [For ELISA Application]
Retinoic Acid Receptor Responder Protein 2 (human) Detection Set [For ELISA Application]
TIG2 (human) Detection Set [For ELISA Application]
Tazarotene-induced Gene 2 (human) Detection Set [For ELISA Application]
RAR-responsive Protein (human) Detection Set [For ELISA Application]
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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APO-54N-040-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.1ng/ml (range 0.156 to 10ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human chemerin from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
Chemerin (tazarotene-induced gene 2; TIG2) is a chemotactic agent that was identified as the ligand for the orphan G protein-coupled receptor ChemR23. Recently, chemerin has been shown to be expressed abundantly in adipose tissue and to function as a new adipokine [1, 2]. Chemerin potentiates insulin-stimulated glucose uptake and regulates adipogenesis and adipocyte metabolism [1].
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism: K.B. Goralski, et al.; J. Biol. Chem. 282, 28175 (2007) Abstract; Full Text
[2] Chemerin is a novel adipokine associated with obesity and metabolic syndrome: K. Bozaoglu, et al.; Endocrinology 148, 4687 (2007) Abstract
Related Products
Further Categories Containing This Product:
ELISA Sets
 
 
ALX-522-142 Revised 26-Sep-08 New product
Chemerin (human) (recombinant)
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SYNONYMS RARRES2 (human) (recombinant)
Retinoic Acid Receptor Responder Protein 2 (human) (recombinant)
TIG2 (human) (recombinant)
Tazarotene-induced Gene 2 Protein (human) (recombinant)
RAR-responsive Protein (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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ALX-522-142-C010   10 µg 390.00 USD Add To Cart
Product Specification
MW: ~20kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human chemerin (aa 21-157) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Lonza).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q99969: RARR2 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • PLA2 Inhibitors • Dopaminergics & Dopamine Receptors / Related Products
 
 
ALX-370-009 Revised 26-Jun-06
Cholesterol 3-sulfate . sodium salt
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-009-M005   5 mg 20.00 USD Add To Cart
ALX-370-009-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C27H45O4S . Na
MW: 465.7 . 23.0
CAS NUMBER: 2864-50-8
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.
Product Specific Literature References
Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C: T. Ikuta, et al.; Cell Growth Differentiation 5, 943 (1994) Abstract
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes: M.F. Denning, et al.; Cell Growth Differentiation 6, 1619 (1995) Abstract
Further Categories Containing This Product:
PKC Activators
 
 
ALX-270-255 Revised 14-Sep-07
Ciglitazone
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SYNONYMS (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione
U-63287
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-255-M001   1 mg 30.00 USD Add To Cart
ALX-270-255-M005   5 mg 80.00 USD Add To Cart
ALX-270-255-M025   25 mg 310.00 USD Add To Cart
Product Specification
FORMULA: C18H23NO3S
MW: 333.5
CAS NUMBER: 74772-77-3
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description
Selective PPARγ agonist.
Product Specific Literature References
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996) Abstract; Full Text
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Löhrke, et al.; J. Endocrinol. 159, 429 (1998) Abstract; Full Text
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999) Abstract; Full Text
Thiazolidinediones--the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens. 21, 157 (1999), (Review) Abstract
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol. 164, 1364 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
 
 
ALX-270-404 Revised 24-Jan-06
Cilostamide
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SYNONYMS N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
OCP 3689
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-404-M005   5 mg 50