• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
NOS Inhibitors (NOS Induction & Enzyme Activity)
You are here: Product Lines > Nitric Oxide Pathway > Nitric Oxide Synthases [NOS] / Related Products > NOS Inhibitors (NOS Induction & Enzyme Activity)
Toolbar - View Selection
 
 Items 20-40 of 86 Page 2 of 5 Select Page: << 1 2 3 4 5  >>  
ALX-106-016 Revised 06-Jun-06
D-allo-Isoleucine
Add to Clipboard
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-016-G001   1 g 80.00 USD Add To Cart
Product Specification
FORMULA: C6H13NO2
MW: 131.2
CAS NUMBER: 1509-35-9
RTECS: BA2930000
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-153-064 Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
Add to Clipboard
SYNONYMS Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-064-M001   1 mg 140.00 USD Add To Cart
ALX-153-064-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA: C228H335N61O49S
MW: 4746.6
APPEARANCE: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane: T. Okamoto, et al.; J. Biol. Chem. 273, 4519 (1998) Abstract; Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med. 6, 1362 (2000) Abstract; Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell 4, 31 (2003) Abstract; Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem. 279, 51630 (2004) Abstract; Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS 102, 761 (2005) Abstract; Full Text
Further Categories Containing This Product:
Peptides • NOS Inhibitors (NOS Induction & Enzyme Activity) • NOS Regulation • Cancer Other Products
 
 
ALX-270-002 Revised 25-Oct-07
L-NIO . dihydrochloride
Add to Clipboard
SYNONYMS L-N5-(1-Iminoethyl)-ornithine . 2HCI
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-002-M025   25 mg 60.00 USD Add To Cart
ALX-270-002-M100   100 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C7H15N3O2 . 2HCl
MW: 173.2 . 73.0
CAS NUMBER: 36889-13-1
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Store desiccated under an inert atmosphere in the freezer at -20°C. Warm to room temperature before opening container. Repack under an inert atmosphere, preferably in a glove box.
HANDLING: Hygroscopic.
HAZARD: IRRITANT.

Product Description
Inhibitor of nitric oxide synthase (NOS).
Product Specific Literature References
Antimetabolites produced by microorganisms. VI. L-N 5 -(1-iminoethyl) ornithine: J.P. Scannell, et al.; J. Antibiot. (Tokyo) 25, 179 (1972) Abstract
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands: M. Palacios, et al.; BBRC 165, 802 (1989) Abstract
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo: D.D. Rees, et al.; Br. J. Pharmacol. 101, 746 (1990) Abstract
Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells: T.B. McCall, et al.; Br. J. Pharmacol. 102, 234 (1991) Abstract
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis: M.S. Mulligan, et al.; Br. J. Pharmacol. 107, 1159 (1992) Abstract
 
 
ALX-270-003 Revised 08-Aug-08
Diphenyleneiodonium chloride
Add to Clipboard
SYNONYMS Dibenziodolium chloride
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-003-M025   25 mg 85.00 USD Add To Cart
ALX-270-003-M100   100 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C12H8ICl
MW: 314.5
CAS NUMBER: 4673-26-1
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 10mg/ml soluble in DMSO (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.
Product Specific Literature References
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977) Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987) Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989) Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990) Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991) Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993) Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001) Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001) Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal 4, 207 (2002) Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004) Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005) Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005) Abstract
Further Categories Containing This Product:
Oxygenases Other Products • Cytochrome P450 [CYP450] / Related Products • Respiratory Chain Other Products
 
 
ALX-270-004 Revised 25-Feb-05
7-Nitroindazole
Add to Clipboard
SYNONYMS 7-NI
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-004-M025   25 mg 25.00 USD Add To Cart
ALX-270-004-M100   100 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C7H5N3O2
MW: 163.1
CAS NUMBER: 2942-42-9
PURITY: ≥97%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in methanol (hot) or DMSO. Sparingly soluble in water.  
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of nitric oxide synthase (NOS). See also 3-bromo-7-nitroindazole (Prod. No. ALX-270-009).
Product Specific Literature References
7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti- nociceptive activity in the mouse without increasing blood pressure: P.K. Moore, et al.; Br. J. Pharmacol. 108, 296 (1993) Abstract
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice: J.B. Schulz, et al.; J. Neurochem. 64, 936 (1995) Abstract
 
 
ALX-270-005 Revised 07-Sep-06
2,4-Diamino-6-hydroxypyrimidine
Add to Clipboard
SYNONYMS DAHP
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-005-M250   250 mg 25.00 USD Add To Cart
ALX-270-005-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C4H6N4O
MW: 126.2
CAS NUMBER: 56-06-4
MERCK INDEX: 14: 2981
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol; slightly soluble in hot water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective inhibitor of GTP cyclohydrolase I, which is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis. Thus it suppresses the activity of nitric oxide synthase (NOS).
Product Specific Literature References
Biopterin. III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin: E.M. Gal, et al.; Neurochem. Res. 3, 69 (1978) Abstract
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts: G. Werner-Felmayer, et al.; J. Exp. Med. 172, 1599 (1990) Abstract
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992) Abstract; Full Text
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993) Abstract; Full Text
2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages: Y.J. Sung, et al.; Int. J. Immunopharmacol. 16, 101 (1994) Abstract
2,4-Diamino-6-hydroxypyrimidine, an inhibitor of tetrahydrobiopterin synthesis, downregulates the expression of iNOS protein and mRNA in primary murine macrophages: C. Bogdan, et al.; FEBS Lett. 363, 69 (1995) Abstract
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein: L. Xie, et al.; J. Biol. Chem. 273, 21091 (1998) Abstract; Full Text
Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats: H.Y. Li, et al.; Crit. Care Med. 30, 2520 (2002) Abstract
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Abstract; Full Text
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein: M.A. Kolinsky & S.S. Gross; J. Biol. Chem. 279, 40677 (2004) Abstract; Full Text
 
 
ALX-270-009 Revised 03-Jul-07
3-Bromo-7-nitroindazole
Add to Clipboard
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-009-M005   5 mg 20.00 USD Add To Cart
ALX-270-009-M025   25 mg 40.00 USD Add To Cart
ALX-270-009-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C7H4BrN3O2
MW: 242.0
CAS NUMBER: 74209-34-0
PURITY: ≥98%
APPEARANCE: Yellowish solid.
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol; also soluble in water containing 10% DMSO or in a 50:50 mixture of water:DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole (Prod. No. ALX-270-004).
Product Specific Literature References
7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci. 57, PL131 (1995) Abstract
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience 78, 393 (1997) Abstract
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol. 324, 11 (1997) Abstract
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res. 870, 80 (2000) Abstract
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry 40, 13448 (2001) Abstract
Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56 (2006) Abstract
 
 
ALX-270-010 Revised 07-Mar-05
L-NIL . dihydrochloride
Add to Clipboard
SYNONYMS L-N6-(1-Iminoethyl)-lysine . 2HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-010-M010   10 mg 35.00 USD Add To Cart
ALX-270-010-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C8H17N3O2 . 2HCl
MW: 187.2 . 73.0
CAS NUMBER: 159190-45-1
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Very hygroscopic.

Product Description
Selective inhibitor of inducible nitric oxide synthase (iNOS; NOS II).
Product Specific Literature References
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase: W.M. Moore, et al.; J. Med. Chem. 37, 3886 (1994) Abstract
 
 
ALX-270-023 Revised 05-Jun-08
α-Guanidinoglutaric acid
Add to Clipboard
SYNONYMS GGA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-023-M010   10 mg 55.00 USD Add To Cart
ALX-270-023-M050   50 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C6H11N3O4
MW: 189.2
CAS NUMBER: 73477-53-9
PURITY: ≥98%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Prior to performing biological experiments, product can be added as the crystalline solid to the buffer of choice to make a stock solution at the desired concentration. We do not recommend storing the stock solution for more than one day.

Product Description
Linear mixed-type inhibitor of neuronal nitric oxide synthase (nNOS/NOS I).
Product Specific Literature References
alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats: A. Mori, et al.; J. Neurochem. 35, 603 (1980) Abstract
alpha-Guanidinoglutaric acid, an endogenous convulsant, as a novel nitric oxide synthase inhibitor: I. Yokoi, et al.; J. Neurochem. 63, 1565 (1994) Abstract
 
 
ALX-270-024 Revised 02-Jan-06
1,4-PB-ITU . dihydrobromide
Add to Clipboard
SYNONYMS S,S'-(1,4-Phenylene-bis(1,2-ethanediyl))bis-isothiourea
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-024-M010   10 mg 19.00 USD Add To Cart
ALX-270-024-M050