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Neuropeptides & Receptors
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ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-152-018 Revised 20-Aug-02
Bombesin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-152-018-P001   1 mg* 40.00 USD Add To Cart
ALX-152-018-P005   5 mg* 160.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
FORMULA: C71H110N24O18S
MW: 1619.9
CAS NUMBER: 31362-50-2
MERCK INDEX: 14: 1329
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: While lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-152-031 Revised 17-Nov-08
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
PEPTIDE CONTENT: ≥85%
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
QUALITY CONTROL: Identity determined by MS.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
NOS Regulation • Peptides • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-157-003 Revised 03-Mar-05
Galanin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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ALX-157-003-PC05   0.5 mg* 190.00 USD Add To Cart
ALX-157-003-P001   1 mg* 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH
FORMULA: C139H210N42O43
MW: 3157.4
CAS NUMBER: 119418-04-1
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Galanin: profile of a new neuropeptide: L.W. Haynes; TIPS 7, 214 (1986), (Review)
Galanin - a newly isolated biologically active neuropeptide: A. Rökaeus; Trends Neurosci. 10, 158 (1987)
Galanin and the endocrine pancreas: B. Ahren, et al.; FEBS Lett. 229, 233 (1988) Abstract
Galanin. A selective inhibitor of insulin secretion?: J. Dupré; Pancreas 3, 119 (1988) Abstract
Co-existence of galanin and acetylcholine: is galanin involved in memory processed and dementia?: J.N. Crawley & G.L. Wenk; TINS 12, 278 (1989) Abstract
Inhibitory action of galanin on gastric acid secretion in pentobarbital-anesthetized rats: W.J. Rossowski & D.H. Coy; Life Sci. 44, 1807 (1989) Abstract
Galanin in the porcine pancreas: T. Messell, et al.; Regul. Pept. 28, 161 (1990) Abstract
Human galanin: primary structure and identification of two molecular forms: M. Bersani, et al.; FEBS Lett. 283, 189 (1991) Abstract
Isolation and primary structure of pituitary human galanin, a 30- residue nonamidated neuropeptide: W.E. Schmidt, et al.; PNAS 88, 11435 (1991) Abstract
Human galanin: molecular cloning reveals a unique structure: H.F. Evans & J. Shine; Endocrinology 129, 1682 (1991) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Modulators • Neuropeptides & Receptors Other Products
 
 
ALX-157-004 Revised 29-Nov-02
Galanin (pig)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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ALX-157-004-PC05   0.5 mg* 180.00 USD Add To Cart
ALX-157-004-P001   1 mg* 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2
FORMULA: C146H213N43O40
MW: 3210.6
CAS NUMBER: 88813-36-9
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
For reviews see Galanin (human) (Prod. No. ALX-157-003).
Product Specific Literature References
Galanin - a novel biologically active peptide from porcine intestine: K. Tatemoto, et al.; FEBS Lett. 164, 124 (1983) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Modulators
 
 
ALX-157-020 Revised 03-Mar-05
Galanin Like Peptide [GALP] (1-60) (pig)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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ALX-157-020-MC01   0.1 mg 490.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA: C281H443N81O78
MW: 6204.1
CAS NUMBER: 245114-96-9
SOURCE/HOST: Isolated from pig hypothalamus.
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC50=0.24nM) and a lower affinity for the galanin receptor 1 (IC50=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.
Product Specific Literature References
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus: T. Ohtaki, et al.; J. Biol. Chem. 274, 37041 (1999) Abstract; Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat: A. Jureus, et al.; Endocrinology 141, 2703 (2000) Abstract; Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain: J.A. Larm & A.L. Gundlach; Neuroendocrinology 72, 67 (2000) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-021 Revised 25-Sep-06
Ghrelin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-157-021-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-021-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C149H249N47O42
MW: 3370.9
CAS NUMBER: 258279-04-8
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in distilled water or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-022 Revised 25-Sep-06
Ghrelin (rat)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-157-022-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-022-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C147H244N45O42
MW: 3313.8
CAS NUMBER: 258338-12-4
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-160-011 Revised 23-Nov-06
Kinetensin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neurotensin / Related Products
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ALX-160-011-M001   1 mg 45.00 USD Add To Cart
ALX-160-011-M005   5 mg 175.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH
FORMULA: C56H85N17O11
MW: 1172.4
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-163-001 Revised 13-Feb-08
Nociceptin
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SYNONYMS Orphanin FQ
PRODUCT LINE Neurobiology
PRODUCT CATEGORY ORL1-Receptors / Related Products
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ALX-163-001-P001   1 mg* 70.00 USD Add To Cart
ALX-163-001-P005   5 mg* 280.00 USD Add To Cart