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Items 14 of 14
ALX-480-001
Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
SYNONYMS
ADP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-001-G001
1 g
45.00 USD
ALX-480-001-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
10
P
2
. 2Na
MW:
471.2 . 46.0
CAS NUMBER:
16178-48-6
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥
95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
SYNONYMS
ADP . K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-002-G001
1 g
45.00 USD
ALX-480-002-G005
5 g
180.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
10
P
2
. K
MW:
426.2 . 39.1
CAS NUMBER:
72696-48-1
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during prolonged storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-014
Revised 25-Oct-06
Adenosine 5'-monophosphate . disodium salt
SYNONYMS
AMP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-014-G005
5 g
68.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
7
P . 2Na
MW:
345.2 . 46.0
CAS NUMBER:
4578-31-8
MERCK INDEX:
14:
158
RTECS:
AU7481600
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water and aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
ALX-480-017
Revised 24-Nov-04
Adenosine 5'-O-thiomonophosphate . dilithium salt
SYNONYMS
5'-AMPS . 2 Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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Format:
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Unit Price:
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ALX-480-017-M001
1 mg
15.00 USD
ALX-480-017-M005
5 mg
45.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
6
PS . 2Li
MW:
361.3 . 13.9
CAS NUMBER:
93839-85-1
PURITY:
≥97%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Product Description
Substrate and inhibitor of AMP-dependent enzyme systems.
Product Specific Literature References
Adenosine 5'-phosphorothioate. A nucleotide analog that is a substrate, competitive inhibitor, or regulator of some enzymes that interact with adenosine 5'-phosphate
:
A.W. Murray & M.R. Atkinson; Biochemistry
7
, 4023 (1968)
Abstract
ALX-480-066
Revised 22-Oct-08
Adenosine 5'-O-(3-thiotriphosphate) . tetralithium salt
SYNONYMS
ATP-γS . 4Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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Format:
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ALX-480-066-M001
1 mg
25.00 USD
ALX-480-066-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
12
P
3
S . 4Li
MW:
520.2 . 27.8
CAS NUMBER:
93889-89-5
PURITY:
≥90%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
HANDLING:
Protect from moisture.
HAZARD:
IRRITANT.
Product Description
ATP analog that can substitute ATP in various kinase reactions. Substrate and inhibitor of ATP-dependent enzyme systems. The resulting thiophosphorylated proteins are resistant to dephosphorylation by protein phosphatases. Increases the activity of Ca
2+
-activated K
+
channels.
Product Specific Literature References
The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate)
:
S. Chrysogelos, et al.; J. Biol. Chem.
258
, 12624 (1983)
Abstract
;
Full Text
Regulation of phosphoinositide breakdown by guanine nucleotides:
I. Litosch & J.N. Fain; Life Sci.
39
, 187 (1986)
Abstract
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation:
J. Chen, et al.; Science
257
, 1261 (1992)
Abstract
Further Categories Containing This Product:
K+ Channel Activators
ALX-480-021
Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
SYNONYMS
ATP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-021-G001
1 g
15.00 USD
ALX-480-021-G005
5 g
45.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
13
P
3
. 2Na
MW:
505.2 . 46.0
CAS NUMBER:
51963-61-2
MERCK INDEX:
14:
155
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Further Categories Containing This Product:
Inflammasome
ALX-480-094
Revised 07-Oct-08
ADP-HPD . ammonium salt . dihydrate
SYNONYMS
Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH
4
. 2H
2
O
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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ALX-480-094-C060
60 µg
188.00 USD
Product Specification
FORMULA:
C
15
H
23
N
6
O
12
P
2
. NH
4
. 2H
2
O
MW:
541.3 . 18.0 . 36.0
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white amorphous solid.
SOLUBILITY:
Soluble in water (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.
Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC
50
=120nM) versus ADP-ribose (IC
50
=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
:
J.T. Slama, et al.; J. Med. Chem.
38
, 389 (1995)
Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
:
J.T. Slama, et al.; J. Med. Chem.
38
, 4332 (1995)
Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage
:
S. Vispe, et al.; PNAS
97
, 9886 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
DNA Repair Other Products
•
PARG / Related Products
ALX-480-028
Revised 16-Dec-04
8-Chloroadenosine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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Format:
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ALX-480-028-M001
1 mg
40.00 USD
ALX-480-028-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
12
ClN
5
O
4
MW:
301.7
CAS NUMBER:
34408-14-5
PURITY:
≥98%
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Cytotoxic metabolite of 8-Cl-cAMP (Prod. No.
ALX-480-029
).
Product Specific Literature References
Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation:
Y.S. Cho-Chung, et al.; Cancer Invest.
7
, 161 (1989)
Abstract
ALX-480-095
Revised 16-Dec-04
2'-Deoxyadenosine 5'-triphosphate . disodium salt
SYNONYMS
dATP
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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ALX-480-095-M010
10 mg
55.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
12
P
3
. 2Na
MW:
489.2 . 46.0
CAS NUMBER:
1927-31-7
PURITY:
≥97% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
ALX-270-095
Revised 07-May-08
5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole
SYNONYMS
DRB
5,6-Dichlorobenzimidazole riboside
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-095-M005
5 mg
20.00 USD
ALX-270-095-M025
25 mg
70.00 USD
Product Specification
FORMULA:
C
12
H
12
Cl
2
N
2
O
4
MW:
319.1
CAS NUMBER:
53-85-0
RTECS:
DD7310000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO (100mM) or dimethyl formamide (100mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Selective casein kinase II inhibitor. Inhibitor of RNA synthesis in eukaryotic cells.
Product Specific Literature References
Halobenzimidazole ribosides and RNA synthesis of cells and viruses:
I. Tamm & P. Sehgal; Adv. Virus Res.
22
, 187 (1978)
Abstract
Mechanism of action of 5,6-dichloro-1-beta-D- ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery:
B. Mittleman, et al.; J. Mol. Biol.
165
, 461 (1983)
Abstract
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription:
R. Zandomeni, et al.; J. Mol. Biol.
167
, 561 (1983)
Abstract
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1- beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription:
R. Zandomeni, et al.; J. Biol. Chem.
261
, 3414 (1986)
Abstract
;
Full Text
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6- dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB):
C.E. Farin & L. Yang; Mol. Reprod. Dev.
37
, 284 (1994)
Abstract
Further Categories Containing This Product:
Casein Kinase Inhibitors
ALX-480-048
Revised 06-Mar-07
2',3'-Dideoxyadenosine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-048-M001
1 mg
15.00 USD
ALX-480-048-M005
5 mg
30.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
2
MW:
235.2
CAS NUMBER:
4097-22-7
MERCK INDEX:
14:
3101
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of adenylate cyclase. Useful tool in antiviral and anticancer studies. Blocks viral reverse transcription from RNA to DNA. Inhibitor of adenosine deaminase.
Product Specific Literature References
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'- dideoxyinosine:
V. Nair & T.B. Sells; Biochim. Biophys. Acta
1119
, 201 (1992)
Abstract
Long-term inhibn. of human T-lymphotropic virus type III/lymphadenopathy-associated virus DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro:
H. Mitsuya, et al.; PNAS
84
, 2033 (1987)
Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
•
Antiviral Agents Other Products
ALX-480-049
Revised 03-Jun-08
2',5'-Dideoxyadenosine
