• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Na+ / K+-ATPase / Related Products
You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products > ATPases / Related Products > Na+ / K+-ATPase / Related Products
Toolbar - View Selection
 
Items 16 of 16
ALX-350-315 Revised 03-Apr-08
Agelasine D
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-315-M001   1 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C26H40N5
MW: 422.6
CAS NUMBER: 92664-80-7
SOURCE/HOST: Isolated from the sponge Agelas nakamurai.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Displays broad spectrum of antibacterial activities. Antineoplastic compound. Associated with contractive responses of smooth muscles and inhibition of Na+/K+-ATPase.
Product Specific Literature References
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities: A. Vik, et al.; J. Nat. Prod. 69, 381 (2006) Abstract
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs: A. Vik, et al.; Bioorg. Med. Chem. 15, 4016 (2007) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Antibiotics - ATPase Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Marine Natural Products
 
 
ALX-350-281 Revised 11-Jun-07
Bufalin
Add to Clipboard
SYNONYMS (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-281-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C24H34O4
MW: 386.5
CAS NUMBER: 465-21-4
MERCK INDEX: 14: 1471
SOURCE/HOST: Isolated from Bufonis venom.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Cardiotonic steroid specific Na+/K+-ATPase inhibitor. More potent than ouabain (Prod. No. ALX-350-066). Induces cell differentiation and apoptosis.
Product Specific Literature References
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990) Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson; Life Sci. 63, 781 (1998) Abstract
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1998), (Review) Abstract
The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 19 (2001) Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-282 Revised 16-Jun-06
Bufotalin
Add to Clipboard
SYNONYMS (3β,5β,16β)-16-(Acetyloxy)-3-,14-dihydroxybufa-20,22-dienolide
3β,14,16β-Trihydroxy-5β bufa-20,22-dienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-282-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C26H36O6
MW: 444.6
CAS NUMBER: 471-95-4
MERCK INDEX: 14: 1477
SOURCE/HOST: Isolated from Bufonis venom.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or chloroform.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.
Product Specific Literature References
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1999), (Review) Abstract
The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 119 (2001) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators
 
 
ALX-350-283 Revised 11-Jun-07
Cinobufagin
Add to Clipboard
SYNONYMS 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-283-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C26H34O6
MW: 442.6
CAS NUMBER: 470-37-1
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. About as active as ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Metabolism and pharmacokinetics of cinobufagin: S. Toma, et al.; Xenobiotica 17, 1195 (1987) Abstract
Specific 12 beta-hydroxylation of cinobufagin by filamentous fungi: M. Ye, et al.; Appl. Environ. Microbiol. 70, 3521 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-284 Revised 11-Jun-07
Cinobufotalin
Add to Clipboard
SYNONYMS 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-284-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 1108-68-5
MERCK INDEX: 14: 2307
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. Less active than ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990) Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson ; Life Sci. 63, 781 (1998) Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators
 
 
ALX-350-105 Revised 05-Apr-08
Hellebrin
Add to Clipboard
SYNONYMS 3β-(O4-β-D-Glucopyranosyl-α-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14-β-bufa-20,22-dienolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-105-M001   1 mg 45.00 USD Add To Cart
ALX-350-105-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C36H52O15
MW: 724.8
CAS NUMBER: 13289-18-4
SOURCE/HOST: Isolated from Helleborus sp.
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Cardiotonic glycoside which presents a bufadienolide-steroid structure. Besides ouabain (Prod. No. ALX-350-066), from the class of cardenolides hellebrin is the second unique water soluble cardiotonic glycoside. Extremely potent inhibitor of Na+/K+-ATPase  (sodium pump) blocking the active efflux of Na+ and reuptake of K+ of this membrane enzyme. Shows a positive inotropic effect by increasing the intracellular Ca2+ concentration. Strong immunosuppressor inhibiting T cell activity with much higher potency than cortisol or cyclosporin A (Prod. No. ALX-380-002). Induces caspase-dependent apoptosis.
Product Specific Literature References
Über Hellebrin, ein krystallisiertes Glykosid aus Radix Hellebori nigri: W. Karrer; Helv. Chim. Acta 26, 1353 (1943)
The structure of hellebrin: P. Muhr, et al.; Liebigs Ann. Org. Bioorg. Chem. 2, 443 (1995)
In search of ideal inotropic steroids: recent progress: K.R. Repke, et al.; Prog. Drug Res. 47, 9 (1996) Abstract
Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response: P. Terness, et al.; Transplant Proc. 33, 547 (2001) Abstract
Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives: D. Daniel, et al.; Int. Immunopharmacol. 3, 1791 (2003) Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Calcium Signalling (Intracellular) Other Products • Natural Products - Immunomodulators • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-804-081 Revised 28-Jul-08
Monoclonal Antibody to Na+/K+ ATPase-α (M7-PB-E9)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-081-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Others
CLONE: M7-PB-E9
ISOTYPE: Mouse IgG1
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Purified sheep kidney Na+/K+ ATPase-α.
SPECIFICITY: Recognizes human, mouse, rat (α3 isoform only), sheep, bovine, pig, dog and chicken Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-082 Revised 12-Nov-07
Monoclonal Antibody to Na+/K+ ATPase-α1 (M8-P1-A3)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-082-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Sheep
Dog
Pig
CLONE: M8-P1-A3
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Sheep kidney Na+/K+ ATPase-α1.
SPECIFICITY: Recognizes the α1 subunit of rat, sheep, pig and dog Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot. Does not cross-react with Xenopus and chicken Na+/K+ ATPase-α1 or with rat Na+/K+ ATPase-α2 and -α3. Recognizes an epitope between aa 496-506 of sheep kidney Na+/K+ ATPase-α.
APPLICATION: Immunohistochemistry (frozen sections (1:100))
Western Blot (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-080 Revised 04-Mar-05
Monoclonal Antibody to Na+/K+ ATPase-α1 (9-A5)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-080-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Dog
Others
CLONE: 9-A5
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified rat kidney Na+/K+ ATPase.
SPECIFICITY: Recognizes an intracellular region near Asp369 of the α1 subunit of human, rat, dog and chicken Na+/K+ ATPase-α.
APPLICATION: ELISA
Immunohistochemistry (1:1'000)
Immunoprecipitation (can be used for affinity purification of the α subunit of Na+/K+ ATPase from dog kidney extracts)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
The Na+/K+ ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The Na+ / K+ ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the a subunit, and an associated smaller glycoprotein, termed the b subunit. Studies indicate that there are three isoforms of the α subunit (α1, α2, α3) and two isoforms of the β subunit (β1 and β2) encoded by two multigene families.The different isoforms of the Na+/K+ ATPase exhibit tissue-specific and developmental patterns of expression. The α1 and β mRNAs are present in all cell types examined, whereas the α2 and α3 mRNAs exhibit a more restricted pattern of cell-specific expression. The α subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-083 Revised 28-Apr-08
Monoclonal Antibody to Na+/K+ ATPase-α3 (XVIF9-G10)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-083-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Sheep
Dog
Monkey
Others
CLONE: XVIF9-G10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Dog cardiac microsomes.
SPECIFICITY: Recognizes the a3 subunit of human, rat, sheep, guinea pig, dog, rabbit and monkey Na+/K+ ATPase-α. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunocytochemistry (5μg/ml)
Immunohistochemistry (frozen sections) (3μg/ml)
Western Blot (1μg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-085 Revised 02-Apr-07
Monoclonal Antibody to Na+/K+ ATPase-β1 (M17-P5-F11)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ / K+-ATPase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-085-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Sheep
Dog
Pig
CLONE: M17-P5-F11
ISOTYPE: Mouse IgG2a
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified sheep kidney Na+/K+ ATPase-β.
SPECIFICITY: Recognizes the β1 subunit of human, sheep, pig and dog Na+/K+ ATPase-β.
APPLICATION: Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot  (1:250)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies