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NOS Inhibitors (NOS Induction & Enzyme Activity)
You are here: Product Lines > Nitric Oxide Pathway > Nitric Oxide Synthases [NOS] / Related Products > NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-013 Revised 04-Mar-05
L-Thiocitrulline . dihydrochloride
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-013-M010   10 mg 50.00 USD Add To Cart
ALX-106-013-M050   50 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C6H13N3O2S . 2HCl
MW: 191.3 . 73.0
CAS NUMBER: 212051-53-1
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of neuronal (nNOS; NOS I) and inducible (iNOS; NOS II) nitric oxide synthase.
Product Specific Literature References
L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric- oxide synthases: C. Frey, et al.; J. Biol. Chem. 269, 26083 (1994) Abstract; Full Text
Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L- thiocitrulline: a new class of potent nitric oxide synthase inhibitors: K. Narayanan & O.W. Griffith; J. Med. Chem. 37, 885 (1994) Abstract
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-350-261 Revised 07-Oct-08
Trichodion
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-261-C100   100 µg 85.00 USD Add To Cart
ALX-350-261-C500   500 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C12H14O5
MW: 238.2
SOURCE/HOST: Isolated from Trichosporiella sp.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cytotoxic. Inhibits NF-κB (IC50=42-84µM), AP-1 (IC50=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.
Product Specific Literature References
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000) Abstract; Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • COX Inhibitors • Other Natural Products for Inflammation Research
 
 
ALX-270-170 Revised 12-Sep-06
TRIM
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SYNONYMS 1-(2-Trifluoromethylphenyl)imidazole
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-170-M050   50 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C10H7F3N2
MW: 212.2
CAS NUMBER: 25371-96-4
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO (30mg/ml) or dichloromethane (25%); slightly soluble in water (5mg/ml), 0.1 N HCl (6mg/ml) or 0.1 N NaOH (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Potent neuronal nitric oxide synthase (nNOS; NOS I) inhibitor.
Product Specific Literature References
The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse: R.L. Handy, et al.; Br. J. Pharmacol. 116, 2349 (1995) Abstract
Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects: R.L. Handy, et al.; Br. J. Pharmacol. 119, 423 (1996) Abstract
Mechanism of the inhibition of neuronal nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM): R.L. Handy & P.K. Moore; Life Sci. 60, PL389 (1997) Abstract
Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat: K.J. Escott, et al.; J. Cereb. Blood Flow Metab. 18, 281 (1998) Abstract
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice: V. Volke, et al.; Behav. Brain Res. 140, 141 (2003) Abstract
 
 
ALX-270-360 Revised 21-May-08
Tryptanthrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
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ALX-270-360-M001   1 mg 50.00 USD Add To Cart
ALX-270-360-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H8N2O2
MW: 248.2
CAS NUMBER: 13220-57-0
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Yellow needles.
SOLUBILITY: Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING: Protect from light and moisture.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, MS and UV.

Product Description
Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. ALX-380-042) resistance on breast cancer cells.
Product Specific Literature References
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001) Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002) Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000) Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003) Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007) Abstract
General Information
Tryptanthrin occurs as a natural product in various plants, including Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria and Calanthe discolor.
Further Categories Containing This Product:
Leukotrienes Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • MDR Inhibitors • Prostaglandins Other Products • P-glycoprotein [Pgp] / Related Products • Natural Products - Nitric Oxide Pathway Modulators • COX Inhibitors
 
 
ALX-270-216 Revised 04-Aug-08
Vinyl-L-NIO
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SYNONYMS N5-(1-Imino-3-butenyl)-L-ornithine
L-VNIO
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-270-216-M005   5 mg 70.00 USD Add To Cart
ALX-270-216-M025   25 mg 245.00 USD Add To Cart
Product Specification
FORMULA: C9H17N3O2 . 2HCl
MW: 199.3 . 73.0
PURITY: ≥95%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Very hygroscopic.

Product Description
Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.
Product Specific Literature References
N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase: B. R. Babu & O.W. Griffith; J. Biol. Chem. 273, 8882 (1998) Abstract; Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Abstract; Full Text
Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines: L.E. Bretscher, et al.; J. Biol. Chem. 278, 46789 (2003) Abstract; Full Text
Myocardial effects of nitric oxide, NO. Clinical and experimental evidence: C. Heymes, et al.; Bull. Acad. Natl. Med. 189, 893 (2005), [Article in French] Abstract
Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries: Y. Hatanaka, et al.; J. Pharmacol. Exp. Ther. 316, 490 (2006) Abstract
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia: K. Kawahara, et al.; J. Mol. Cell Cardiol. 40, 35 (2006) Abstract
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats: L.M. Yamaleyeva, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R819 (2007) Abstract
General Literature References
Design of isoform-selective inhibitors of nitric oxide synthase: B.R. Babu & O.W. Griffith; Curr. Opin. Chem. Biol. 2, 491 (1998) Abstract
 
 
ALX-430-049 Revised 25-Nov-08
Zinc(II) Protoporphyrin IX
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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ALX-430-049-M005   5 mg 20.00 USD Add To Cart
ALX-430-049-M025   25 mg 60.00 USD Add To Cart
ALX-430-049-M100   100 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C34H32N4O4Zn
MW: 626.0
CAS NUMBER: 15442-64-5
PURITY: ≥95% (TLC)
APPEARANCE: Dark red to violet solid.
SOLUBILITY: Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base;  slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING: Protect from light and moisture.
IDENTITY: Identity determined by UV and NMR.

Product Description
Potent and selective inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier.
Product Specific Literature References
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 32, 497 (1987) Abstract
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function: G.S. Marks, et al.; Can. J. Physiol.Pharmacol. 71, 753 (1993) Abstract
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus: M. Zhuo, et al; Science 260, 1946 (1993) Abstract
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats: C. Kadoya, et al.; Stroke 26, 1035 (1995) Abstract; Full Text
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase: L. Ny, et al.; Br. J. Pharmacol. 115, 186 (1995) Abstract
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter: S. Chakder, et al.; J. Pharmacol. Exp. Ther. 277, 1376 (1996) Abstract
Inhibition of nitric oxide synthase isoforms by porphyrins: D.J. Wolff, et al.; Arch. Biochem. Biophys. 333, 27 (1996) Abstract
Pitfalls using metalloporphyrins in carbon monoxide research: L. Grundemar and L. Ny; TIPS 18, 193 (1997), (Review) Abstract
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock: S.F. Yet, et al.; J. Biol. Chem. 272, 4295 (1997) Abstract; Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity: L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys. 359, 8 (1998) Abstract
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX: S. Rattan, et al.; Am. J. Physiol. 276, G138 (1999) Abstract; Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • Heme Oxygenase / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
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