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ALX-804-278
Revised 31-Oct-06
Monoclonal Antibody to Hepatitis Bx Protein (X36C)
SYNONYMS
anti-HBx Protein MAb (X36C)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-278-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE:
X36C
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant HBx protein (hepatitis Bx protein).
SPECIFICITY:
Recognizes HBx. Detects a band of ~17kDa by Western blot.
APPLICATION:
ELISA
Immunoprecipitation (does not immunoprecipitate HBx complexed with XIP)
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-277
Revised 14-Dec-06
Monoclonal Antibody to Hepatitis C Core Protein (C7-50)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-277-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE:
C7-50
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified HCV (hepatitis C virus) core fusion protein (genotype 1b).
SPECIFICITY:
Recognizes epitope between aa 21-40 of HCV core protein. This sequence is conserved among different HCV strains. Detects a band of ~21kDa by Western blot.
APPLICATION:
ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of three novel monoclonal antibodies against hepatitis C virus core protein
:
D. Moradpour, et al.; J. Med. Virol.
48
, 234 (1996)
Abstract
General Information
Hepatitis C virus (HCV) is the primary cause of non-A, non-B hepatitis and results in most HCV-infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. The 21kDa core protein of HCV is well conserved among different HCV genotypes and may suppress hepatitis B virus replication in a phosphorylation dependent manner.
BACKGROUND/TECHNICAL INFORMATION
Immunocytochemical staining of HCV core protein in transfected chimp hepatocytes yields a staining pattern consistent with cytoplasmic and vesicular staining.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-803-059
Revised 27-Apr-06
Monoclonal Antibody to NS3 (HCV) (1B6)
SYNONYMS
anti-Nonstructural Protein 3 (HCV) MAb (1B6)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-059-R100
100 µl
360.00 USD
Product Specification
CLONE:
1B6
ISOTYPE:
Mouse IgG1
PURITY:
Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
SPECIFICITY:
Recognizes HCV NS3 (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex.
APPLICATION:
Immunocytochemistry (1:50)
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines:
B. Wolk, et al.; J. Virol.
74
, 2293 (2000)
Abstract
;
Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins:
Dimitrova, et al.; J. Virol.
77
, 5401 (2003)
Abstract
;
Full Text
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons:
R. Gosert, et al.; J. Virol.
77
, 5487 (2003)
Abstract
;
Full Text
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes:
D. Moradpour, et al.; J. Virol.
78
, 7400 (2004)
Abstract
;
Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus:
E. Meylan, et al.; Nature
437
, 1167 (2005)
Abstract
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids:
S.B. Kapadia and F.V. Chisari; PNAS
102
, 2561 (2005)
Abstract
;
Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus:
E. Meylan, et al.; Nature
437
, 1167 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Unravelling hepatitis C virus replication from genome to function:
B.D. Lindenbach and C.M. Rice; Nature
436
, 933 (2005)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-803-061
Revised 26-Apr-07
Monoclonal Antibody to NS5B (HCV) (5B-12B7)
SYNONYMS
anti-Nonstructural Protein 5B (HCV) MAb (5B-12B7)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-061-R100
100 µl
360.00 USD
Product Specification
CLONE:
5B-12B7
ISOTYPE:
Mouse IgG2a
PURITY:
Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY:
Recognizes HCV NS5B (epitope mapped to NS5B aa 139-392).
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Functional Application: Blocks the RNA-dependent RNA polymerase activity
in vitro
.
Note:
Not suitable for Western blot. Use MAb to NS5B (HCV) (5B-3B1) (Prod. No.
ALX-803-060
).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase:
J. Schmidt-Mende, et al.; J. Biol. Chem.
276
, 44052 (2001)
Abstract
;
Full Text
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase:
D. Moradpour, et al.; J. Biol. Chem.
277
, 593 (2002)
Abstract
;
Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins:
Dimitrova, et al.; J. Virol.
77
, 5401 (2003)
Abstract
;
Full Text
Interference of hepatitis C virus RNA replication by short interfering RNAs:
Kapadia, et al.; PNAS
100
, 2014 (2003)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Unravelling hepatitis C virus replication from genome to function:
B.D. Lindenbach and C.M. Rice; Nature
436
, 933 (2005)
Abstract
Related Products
ALX-803-060
Monoclonal Antibody to NS5B (HCV) (5B-3B1)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-803-060
Revised 27-Apr-06
Monoclonal Antibody to NS5B (HCV) (5B-3B1)
SYNONYMS
anti-Nonstructural Protein 5B (HCV) MAb (5B-3B1)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-060-R100
100 µl
360.00 USD
Product Specification
CLONE:
5B-3B1
ISOTYPE:
Mouse IgG2b
FORMULATION:
Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY:
Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382).
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase:
D. Moradpour, et al.; J. Biol. Chem.
277
, 593 (2002)
Abstract
;
Full Text
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells:
R.W. Hardy, et al.; J. Virol.
77
, 2029 (2003)
Abstract
;
Full Text
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs:
G. Randall, et al.; PNAS
100
, 235 (2003)
Abstract
;
Full Text
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids:
S.B. Kapadia and F.V. Chisari; PNAS
102
, 2561 (2005)
Abstract
;
Full Text
Quantitative analysis of the hepatitis C virus replication complex:
D. Quinkert, et al.; J. Virol.
79
, 13594 (2005)
Abstract
Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3:
Y.V. Svitkin, et al.; J. Virol.
79
, 6868 (2005)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation
General Literature References
Unravelling hepatitis C virus replication from genome to function:
B.D. Lindenbach and C.M. Rice; Nature
436
, 933 (2005)
Abstract
Related Products
ALX-803-061
Monoclonal Antibody to NS5B (HCV) (5B-12B7)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-201-247
Revised 18-Mar-08
NS3-NS4A (HCV) (recombinant) (His)
SYNONYMS
Nonstructural Protein 3-NS4A (HCV) (recombinant) (His)
Hepacivirin-NS4A (HCV) (recombinant) (His)
PRODUCT LINE
Viral Signalling
PRODUCT CATEGORY
Hepatitis Viruses / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-247-C100
100 µg
210.00 USD
Product Specification
MW:
~68.7kDa (NS3 subunit); ~6.2kDa (NS4A subunit)
EC:
3.4.21.98
SOURCE/HOST:
Produced in
E. coli
. Recombinant hepatitis C virus (HCV) NS3-NS4A serine protease complex is fused to a His-tag.
CONCENTRATION:
379ng/μl (5µM)
PURITY:
≥85% (SDS-PAGE)
FORMULATION:
Liquid. In 25mM HEPES, pH 7.6, containing 1mM EDTA, 3mM DTT, 0.5M sodium chloride, 0.2% Triton X-100 and 20% glycerol.
BIOLOGICAL ACTIVITY:
IC
50
(lot-specific)
APPLICATION:
Suitable for screenings.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
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