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ALX-210-885
Revised 18-Sep-07
Polyclonal Antibody to c-IAP1
SYNONYMS
anti-Cellular Inhibitor of Apoptosis-1 PAb
anti-HIAP2 PAb
anti-Inhibitor of Apoptosis Protein-2 (human) PAb
anti-BIRC-2 PAb
anti-Baculoviral IAP Repeat-containing Protein-2 PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
c-IAP1 [HIAP2, BIRC-2]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-885-R100
100 µl
240.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.2% sodium azide.
IMMUNOGEN:
Purified recombinant human c-IAP1 (aa 351-618).
SPECIFICITY:
Recognizes endogenous human and mouse (weak) c-IAP1. Does not cross-react with c-IAP2.
APPLICATION:
Western Blot (1:500)
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins
:
E.M. Creagh, et al.; J. Biol. Chem.
279
, 26906 (2004)
Abstract
;
Full Text
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex:
K. Izeradjene, et al.; Cancer Res.
64
, 8036 (2004)
Abstract
;
Full Text
Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes
:
M.M. Hill, et al.; Embo J.
23
, 2134 (2004)
Abstract
General Information
Inhibitor of Apoptosis Proteins [IAP]
All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA).
General Literature References
Destabilizing influences in apoptosis: sowing the seeds of IAP destruction
:
S.J. Martin; Cell
109
, 793 (2002), Review
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-243
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (NT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-243-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.0mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-30 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse, rat and hamster CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Immunohistochemistry
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-031
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of
Drosophila per
. PER, in concert with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-244
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (mouse) (CT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-244-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.9mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-411 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-032
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of
Drosophila per
. PER, in concert with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-451
Revised 31-Aug-06
Polyclonal Antibody to Clusterin (human)
SYNONYMS
anti-TRPM-2 (human) PAb
anti-Apolipoprotein J (human) PAb
anti-APO-J (human) PAb
anti-CLI (human) PAb
anti-CLU (human) PAb
anti-SGP-2 (human) PAb
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-451-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human secretory clusterin.
SPECIFICITY:
Recognizes human serum or plasma clusterin. Detects a band of ~40kDa by Western blot.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-930
Revised 26-Feb-07
Polyclonal Antibody to Clusterin (human) (AT109)
SYNONYMS
anti-TRPM-2 (human) PAb (AT109)
anti-Apolipoprotein J (human) PAb (AT109)
anti-APO-J (human) PAb (AT109)
anti-CLI (human) PAb (AT109)
anti-CLU (human) PAb (AT109)
anti-SGP-2 (human) PAb (AT109)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-930-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human clusterin (aa 23-449).
SPECIFICITY:
Recognizes human clusterin.
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Clusterin (human) (recombinant) (Prod.No.
ALX-522-089
)
General Information
Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate
:
J.G. Leger, et al.; BBRC
147
, 196 (1987)
Abstract
Apolipoprotein J: structure and tissue distribution
:
H.V. De Silva, et al.; Biochemistry
29
, 5380 (1990)
Abstract
Clusterin: the intriguing guises of a widely expressed glycoprotein
:
D.E. Jenne & J. Tschopp; Trends Biochem. Sci.
17
, 154 (1992)
Abstract
Clusterin
:
S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol.
34
, 427 (2002), (Review)
Abstract
Clusterin/Apolipoprotein J in human aging and cancer
:
I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol.
34
, 1430 (2002)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-457
Revised 07-Feb-07
Polyclonal Antibody to Clusterin (mouse)
SYNONYMS
anti-TRPM-2 (mouse) PAb
anti-Apolipoprotein J (mouse) PAb
anti-APO-J (mouse) PAb
anti-CLI (mouse) PAb
anti-CLU (mouse) PAb
anti-SGP-2 (mouse) PAb
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-457-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse nuclear clusterin.
SPECIFICITY:
Recognizes mouse serum or plasma clusterin.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-064
Revised 28-Oct-08
Polyclonal Antibody to Complement Factor H (human) (NT)
SYNONYMS
anti-CFH (human) (NT) PAb
anti-Factor H (human) (NT) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Complement Factors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-215-064-1
1 Vial
260.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
QUANTITY:
100µl
FORMULATION:
Liquid. Serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human CFH (complement factor H) (SCR domains 1-4).
SPECIFICITY:
Recognizes human CFH and its splice variant FHL-1. Detects bands of ~150kDa (CFH) and ~41kDa (FHL-1) by Western blot. Does not cross-react with factor H related proteins FHR-1, FHR-2 or FHR-3.
APPLICATION:
ELISA
Flow Cytometry
Immunocytochemistry
Immunohistochemistry
Western Blot (1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration:
C. Skerka, et al.; Mol. Immunol.
44
, 3398 (2007)
Abstract
Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1:
P. Herzberger, et al.; Infect. Immun.
75
, 4817 (2007)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-884
Revised 03-Jun-05
Polyclonal Antibody to α-COP
SYNONYMS
anti-α-Coat Protein PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Golgi Apparatus
Ordering Information
Product Numbers:
Format:
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ALX-210-884-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-19 (M
1
LTKFETKSARVK
GLSFHP
19
) of rat α-COP (coat-protein (α subunit)).
SPECIFICITY:
Recognizes human and rat α-COP. Detects bands of ~140kDa (representing α-COP) and ~100kDa (unidentified) by Western blot.
APPLICATION:
Immunocytochemistry
: (3µg/ml)
Immunocytochemical staining results in α-COP localization to the Golgi complex and to distinct vesicular structures scattered throughout the cytoplasm.
Western Blot
(1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-057
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-153-057
Blocking Peptide for PAb to α-COP (Prod. No.
ALX-210-884
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-127
Revised 09-Aug-07
Polyclonal Antibody to β-COP
SYNONYMS
anti-β-Coat Protein PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Golgi Apparatus
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-127-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 496-513 (E
496
AGELKPEEEITVGPVQK
513
) of rat β-COP (β-coat protein).
SPECIFICITY:
Recognizes human, mouse and rat β-COP. Detects a band of~110kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:2’000) [1]
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin:
R. Duden, et al.; Cell
64
, 649 (1991)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-886
Revised 07-Dec-06
Polyclonal Antibody to β'-COP (rat)
SYNONYMS
anti-β'-Coat Protein (rat) PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Golgi Apparatus
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-886-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 494-511 (K
494
VLAAQETHEGV
TEDGIE
511
) of rat β’-COP (coat-protein (β’ subunit)).
SPECIFICITY:
Recognizes rat β’-COP. Detects a band of ~115kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-058
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-153-058
Blocking Peptide for PAb to β'-COP (rat) (Prod. No.
ALX-210-886
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-887/1
Revised 14-Aug-07
Polyclonal Antibody to COPII (rat)
SYNONYMS
anti-Coat Protein II (rat) PAb
anti-SEC23 (rat) PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Golgi Apparatus
