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Microtubule Modulators
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ALX-351-006 Revised 07-Jan-08
Baccatin III, 10-Deacetyl-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-351-006-M005   5 mg 190.00 USD Add To Cart
ALX-351-006-M025   25 mg 590.00 USD Add To Cart
Product Specification
FORMULA: C29H36O10
MW: 544.6
CAS NUMBER: 32981-86-5
SOURCE/HOST: Isolated from Taxus baccata.
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description
Intermediate for the preparation of taxol analogs.
Product Specific Literature References
Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators
 
 
ALX-350-101 Revised 03-Apr-08
Catharanthine . tartrate
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SYNONYMS 3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate
7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-101-M100   100 mg 160.00 USD Add To Cart
ALX-350-101-G001   1 g 430.00 USD Add To Cart
Product Specification
FORMULA: C21H24N2O2 . C4H6O6
MW: 336.4 . 150.1
CAS NUMBER: 2648-21-5
MERCK INDEX: 14: 1904
SOURCE/HOST: Isolated from Catharanthus roseus.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Keep cool and dry.

Product Description

Starting material for the synthesis of the antitumor drugs vinblastine and vincristine.  It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.

Product Specific Literature References
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990) Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991) Abstract
Related Products
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids • Natural Products - Antitumor Reagents
 
 
ALX-430-033 Revised 19-Jul-07
Colcemid
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SYNONYMS Demecolcine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-430-033-M001   1 mg 30.00 USD Add To Cart
ALX-430-033-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO5
MW: 371.4
CAS NUMBER: 477-30-5
MERCK INDEX: 14: 2887
SOURCE/HOST: Semisynthetic from colchicine (Prod. No. ALX-380-033).
PURITY: ≥99%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in 100% ethanol, chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Stock solutions are stable for at least 6 months when stored at -20°C.
HAZARD: MAY BE MUTAGENIC. MAY BE TERATOGENIC. TOXIC.

Product Description
Depolymerizes microtubules and inhibits their formation. Induces apoptosis.
Product Specific Literature References
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res. 198, 214 (1992) Abstract
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992) Abstract
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res. 31, 494 (1992) Abstract
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol. 456, 591 (1992) Abstract
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994) Abstract
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998) Abstract
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999) Abstract
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000) Abstract
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Microtubule Modulators
 
 
ALX-380-033 Revised 17-Oct-07
Colchicine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-380-033-G001   1 g 58.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO6
MW: 399.4
CAS NUMBER: 64-86-8
MERCK INDEX: 14: 2471
RTECS: GH0700000
SOURCE/HOST: Isolated from Colchicum autumnale.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Inhibitor of microtubules by specific binding to tubulin. Induces apoptosis.
Product Specific Literature References
A new colchicine binding assay for tubulin: P. Sherline, et al.; Anal. Biochem. 62, 400 (1974) Abstract
Fluorometric assay of tubulin-colchicine complex: T. Arai & T. Okuyama; Anal. Biochem. 69, 443 (1975) Abstract
Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change: D.L. Garland; Biochemistry 17, 4266 (1978) Abstract
Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin: K.W. Farrell & L. Wilson; Biochemistry 19, 3048 (1980) Abstract
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine: E.D. Salmon, et al.; J. Cell. Biol. 99, 1066 (1984) Abstract
The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells: M.F. Lueng & A.C. Sartorelli; Leuk. Res. 16, 929 (1992) Abstract
Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type 1 expression in human endothelial cells: L. Santell, et al.; Exp. Cell. Res. 201, 358 (1992) Abstract
Colchicine induces apoptosis in cerebellar granule cells: E. Bonfoco, et al.; Exp. Cell. Res. 218, 189 (1995) Abstract
Inhibition of drug-induced apoptosis by survival factors in PC12 cells: L. Lindenboim, et al.; J. Neurochem. 64, 1054 (1995) Abstract
General features of the recognition by tubulin of colchicine and related compounds: Y. Engelborghs; Eur. Biophys. J. 27, 437 (1998) Abstract
Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress: Y.L. Hu, et al.; Am. J. Physiol. 277, H1593 (1999) Abstract
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells: A.M. Gorman, et al.; Eur. J. Neurosci. 11, 1067 (1999) Abstract
Colchicine protects mice from the lethal effect of an agonistic anti- Fas antibody: G. Feng & N. Kaplowitz; J. Clin. Invest. 105, 329 (2000) Abstract
Update on colchicine and its mechanism of action: Y. Molad; Curr. Rheumatol. Rep. 4, 252 (2002) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Alkaloids • Natural Products with Antibiotic Activity
 
 
ALX-380-057 Revised 03-Apr-08
Cytochalasin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-057-M001   1 mg 50.00 USD Add To Cart
ALX-380-057-M005   5 mg 170.00 USD Add To Cart
ALX-380-057-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C29H35NO5
MW: 477.6
CAS NUMBER: 14110-64-6
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Helminthosporium dematioideum.
PURITY: ≥98% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Fungal toxin. Inhibits glucose transport, actin polymerisation and blocks the formation of microtubuli. Inhibits cell division. Inhibits HIV-1 protease.
Product Specific Literature References
The action of cytochalasin A on the in vitro polymerization of brain tubulin and muscle G-actin: R.H. Himes & L.L. Houston; J. Supramol. Struct. 5, 81 (1976) Abstract
Cytochalasin A inhibits B-lymphocyte capping and activation by antigens: G. Teti, et al.; Immunol. Lett. 3, 151 (1981) Abstract
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activity: R.B. Lingham, et al.; J. Antibiot. 45, 686 (1992) Abstract
Effect of cytochalasin A on apical growth, actin cytoskeleton organization and enzyme secretion in Aspergillus nidulans: S. Torralba, et al.; Microbiology 144 (Pt 1), 45 (1998) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids • Mycotoxins
 
 
ALX-380-012 Revised 16-Jun-08
Cytochalasin B
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SYNONYMS Phomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-012-M001   1 mg 35.00 USD Add To Cart
ALX-380-012-M005   5 mg 90.00 USD Add To Cart
ALX-380-012-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C29H37NO5
MW: 479.6
CAS NUMBER: 14930-96-2
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Cell permeable mycotoxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Product Specific Literature References
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972) Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972) Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Review Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse, et al.; Cell Biochem. Funct. 5, 183 (1987) Abstract
Apoptosis induced by adenosine in human leukemia HL-60 cells: Y. Tanaka, et al.; Exp. Cell Res. 213, 242 (1994) Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos, et al.; Biochem. Pharmacol. 47, 1875 (1994) Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky, et al.; Life Sci. 66, 271 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Alkaloids • Actin / Related Products
 
 
ALX-350-053 Revised 03-Apr-08
Cytochalasin B, Dihydro-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-350-053-M001   1 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C29H39NO5
MW: 481.6
CAS NUMBER: 39156-67-7
MERCK INDEX: 14: 2790
SOURCE/HOST: Semisynthetic. Derived from cytochalasin B (Prod. No. ALX-380-012), which was isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in or acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Used as tool in cytological research and in characterization of polymerization properties of actin.
Product Specific Literature References
Dihydrocytochalasin B. Biological effects and binding to 3T3 cells: S.J. Atlas & S. Lin; J. Cell. Biol. 76, 360 (1978) Abstract
Microfilament modification by dihydrocytochalasin B causes retinoic acid-modulated chondrocytes to reexpress the differentiated collagen phenotype without a change in shape: P.D. Benya, et al.; J. Cell Biol. 106, 161 (1988) Abstract
Dihydrocytochalasin B enhances transforming growth factor-beta-induced reexpression of the differentiated chondrocyte phenotype without stimulation of collagen synthesis: P.D. Benya & S.R. Padilla; Exp. Cell Res. 204, 268 (1993) Abstract
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways: K. Wenzel-Seifert, et al.; J. Leukoc. Biol. 61, 703 (1997) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Actin / Related Products • Alkaloids
 
 
ALX-380-069 Revised 26-Jun-08
Cytochalasin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-069-M001   1 mg 60.00 USD Add To Cart
ALX-380-069-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-76-9
MERCK INDEX: 14: 2790
RTECS: HA5300500
SOURCE/HOST: Isolated from Metarhizium anisopliae.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE TERATOGENIC. VERY TOXIC.

Product Description
Antibiotic. Disrupts the actin microfilament cytoskeleton and inhibits the cytoplasmic dividing of a cell. Has been found to be ten times less toxic in mice than cytochalasin D (Prod. No. ALX-380-031) but with essentially the same biological effectiveness against cells in culture.
Product Specific Literature References
Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery: E.A. Walling, et al.; Arch. Biochem. Biophys. 264, 321 (1988) Abstract
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts: M. Varedi, et al.; J. Invest. Dermatol. 104, 118 (1995) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids
 
 
ALX-380-031 Revised 29-Apr-08
Cytochalasin D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-031-M001   1 mg 60.00 USD Add To Cart
ALX-380-031-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-77-0
MERCK INDEX: 14: 2790
RTECS: GZ4850000
SOURCE/HOST: Isolated from Zygosporium mansonii.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methylene chloride (10mg/ml); slighly soluble in DMSO (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: