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Mitochondrial Pathway
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ALX-152-027 Revised 14-Jul-08
BimL (147-164) (human) (cell permeable)
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SYNONYMS BCL2L11 (147-164) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bim / Related Products
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ALX-152-027-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-WIAQELRRIGDEFNAYYA-amide
FORMULA: C161H261N61O41
MW: 3707.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Peptides
 
 
ALX-152-028 Revised 14-Jul-08
Bax (58-75) (human) (cell permeable)
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SYNONYMS BCL2L4 (58-75) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bax / Related Products
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ALX-152-028-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-KLSECLKRIGDELDSNME-amide
FORMULA: C144H260N58O44S2
MW: 3572.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Peptides
 
 
ALX-152-029 Revised 14-Jul-08
Bok (66-83) (human) (cell permeable)
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SYNONYMS NBK (66-83) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-152-029-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-EVCTVLLRLGDELEQIRP-amide
FORMULA: C149H269N59O41S
MW: 3575.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Further Categories Containing This Product:
Peptides
 
 
ALX-158-011 Revised 12-Sep-05
Humanin (human)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
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ALX-158-011-MC05   0.5 mg 210.00 USD Add To Cart
ALX-158-011-M001   1 mg 350.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
FORMULA: C119H204N34O32S2
MW: 2687.3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein [1]. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function [1-3]. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin [4]. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Product Specific Literature References
[1] A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta: Y. Hashimoto, et al.; PNAS 98, 6336 (2001) Abstract; Full Text
[2] Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults: Y. Hashimoto, et al.; J. Neurosci. 21, 9235 (2001) Abstract; Full Text
[3] Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein: Y. Hashimoto, et al.; BBRC 283, 460 (2001) Abstract
[4] Humanin peptide suppresses apoptosis by interfering with Bax activation: B. Guo, et al.; Nature 423, 456 (2003) Abstract
Further Categories Containing This Product:
Peptides • Bcl-2 Family Interacting Proteins / Related Products
 
 
ALX-165-067 Revised 16-May-06
PUMA (135-154) (cell permeable)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Noxa & PUMA / Related Products
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ALX-165-067-1   1 Vial 240.00 USD Add To Cart
Product Specification
SEQUENCE: REIGAQLRRMADDLNAQYER-GG-rrrqrrkkr-G-amide
FORMULA: C158H276N68O45S
MW: 3897.4
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
POSITIVE CONTROL: Prod. No. ALX-168-010
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
BH3-Only proteins-essential initiators of apoptotic cell death: D.C. Huang and A. Strasser; Cell 103, 839 (2000) Abstract
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Peptides
 
 
ALX-201-111 Revised 03-Mar-05
tBid (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
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ALX-201-111-C020   20 µg 230.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Truncated C-terminal human Bid (aa 61-195) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE). Affinity purified
FORMULATION: Liquid. In PBS.
BIOLOGICAL ACTIVITY: Facilitates Bax oligomerization and induces cytochrome c release in isolated mitochondria (~10-50ng/ml).
APPLICATION: Studies of Bid/Bax interaction and in vitro cytochrome c release.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
General Information
Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems. Bid action has been proposed to involve the mitochondrial re-location of its truncated from tBid, to facilitate the release of apoptogenic proteins like cytochrome c.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P55957: Bid (human)
AfCS Signalling Gateway link A002558: Bid (mouse)
General Literature References
Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes: X.M. Yin; J. Mol. Med. 78, 203 (2000) Abstract
The roles of Bid: M.D. Esposti; Apoptosis 7, 433 (2002) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-201-125 Revised 10-Feb-05
Prothymosin α (1-99) (human) (recombinant)
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SYNONYMS ProTα (1-99) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
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ALX-201-125-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Corresponding to the caspase-3 cleavage product of prothymosin α (ProTα) isolated from apoptotic human cells (no affinity-tags, no added additional (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 1.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (1995) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
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Recombinant Proteins / Fusion Proteins
 
 
ALX-201-126 Revised 10-Feb-05
Prothymosin α (1-109) (human) (recombinant)
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SYNONYMS ProTα (1-109) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
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ALX-201-126-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Native sequence representing mature prothymosin α (ProTα) isolated from human cells (no affinity-tags, no additional added (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 2.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
BIOLOGICAL ACTIVITY: Stimulates mouse thymocytes comparable to native ProTα [1].
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (2003) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; J. Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-161 Revised 13-Dec-04
Apaf-1 (rat) (recombinant) (His)
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SYNONYMS Apoptosis Protease-activating Factor 1 (rat) (recombinant) (His)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Apaf-1
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ALX-201-161-C025   25 µg 380.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Full-length rat Apaf-1 with a C-terminal His-tag.
CONCENTRATION: 0.25mg/ml
PURITY: ~95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 8.5.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stability at -20°C: 1-2 weeks.
HANDLING: Avoid freeze/thaw cycles.
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Recombinant Proteins / Fusion Proteins
 
 
ALX-201-230 Revised 26-Apr-06
Endonuclease G (rat) (recombinant)
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SYNONYMS EndoG (rat) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY HtrA2 / Omi, ARTS, EndoG / Related Products
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ALX-201-230-C020   20 µg 190.00 USD Add To Cart
Product Specification
CONCENTRATION: 0.4mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 8.0, containing 500mM sodium chloride, 0.05% Tween 20, 5mM β-mercaptoethanol, 500mM imidazole and 20% glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
DNA Endonucleases / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-244 Revised 27-Mar-07
Endonuclease G (human) (recombinant)
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SYNONYMS EndoG (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY HtrA2 / Omi, ARTS, EndoG / Related Products
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ALX-201-244-C020   20 µg 190.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Recombinant human endonuclease G is fused to a His-tag at the C-terminus.
CONCENTRATION: 0.4mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 8.0, containing 500mM sodium chloride, 0.05% Tween 20, 5mM β-mercaptoethanol, 500mM imidazole and 20% glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
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Further Categories Containing This Product:
DNA Endonucleases / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-245 Revised 27-Apr-06
CED-4 (C. elegans) (recombinant)
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SYNONYMS Cell Death Protein 4 (C. elegans) (recombinant)
PRODUCT LINE