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Leukotrienes Other Products
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ALX-430-063 Revised 10-Oct-07
Anthralin
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SYNONYMS Dithranol
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-430-063-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C14H10O3
MW: 226.2
CAS NUMBER: 1143-38-0
MERCK INDEX: 14: 684
RTECS: CB8927000
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. IRRITANT.

Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB4 ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils: J.M. Schröder; J. Invest. Dermatol. 87, 624 (1986) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Cancer Other Products
 
 
ALX-385-022 Revised 07-Oct-08
Baicalein
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SYNONYMS 5,6,7-Trihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-022-M005   5 mg 25.00 USD Add To Cart
ALX-385-022-M025   25 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 491-67-8
MERCK INDEX: 14: 942
PURITY: ≥97%
APPEARANCE: Yellow to yellow-green crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.
Product Specific Literature References
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987) Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989) Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990) Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994) Abstract
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998) Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
: S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001) Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003) Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005) Abstract
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review) Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007) Abstract
Further Categories Containing This Product:
Leukotrienes Other Products • Natural Products - Anti-inflammatory Agents • Natural Products for Angiogenesis Research • Lipoxygenases / Related Products • Natural Products - Protein Kinase Inhibitors • Tyrosine Kinase Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products for Cell Cycle Research
 
 
ALX-270-090 Revised 14-May-03
Dapsone
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SYNONYMS 4,4'-Diaminodiphenyl sulfone
DDS
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-270-090-G001   1 g 10.00 USD Add To Cart
ALX-270-090-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C12H12N2O2S
MW: 248.3
CAS NUMBER: 80-08-0
MERCK INDEX: 14: 2822
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in  100% ethanol, DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Leukotriene B4 (LTB4) antagonist. Inhibits LTB4 induced lysozyme release.
Product Specific Literature References
Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels: B.L. Maloff, et al.; Eur. J. Pharmacol. 158, 85 (1988) Abstract
 
 
ALX-340-026 Revised 16-Jun-06
LY-171,883
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SYNONYMS 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-340-026-M010   10 mg 68.00 USD Add To Cart
Product Specification
FORMULA: C16H22N4O3
MW: 318.4
CAS NUMBER: 88107-10-2
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Organic stock solutions are stable for at least six months when stored at –20°C.

Product Description
Competitive leukotriene D4 (LTD4) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985) Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993) Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994) Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995) Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
 
 
ALX-340-021 Revised 04-Jun-08
MK-571 . sodium salt
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-340-021-M005   5 mg 45.00 USD Add To Cart
ALX-340-021-M025   25 mg 190.00 USD Add To Cart
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Product Specification
FORMULA: C26H26ClN2O3S2 . Na
MW: 514.1 . 23.0
CAS NUMBER: 115104-28-4
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Leukotriene LTD4 receptor antagonist that potently inhibits MRP1.
Product Specific Literature References
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; BBRC 208, 345 (1995) Abstract
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide: L. Vernhet, et al.; Biochem. Pharmacol. 61, 1387 (2001) Abstract
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic: J. Liu, et al.; Mol. Pharmacol. 60, 302 (2001) Abstract
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?: K. Jones, et al.; Aids 15, 1353 (2001) Abstract
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells: U. Stein, et al.; Int. J. Cancer 97, 751 (2002) Abstract
Further Categories Containing This Product:
MDR Inhibitors
 
 
ALX-270-360 Revised 21-May-08
Tryptanthrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
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ALX-270-360-M001   1 mg 50.00 USD Add To Cart
ALX-270-360-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H8N2O2
MW: 248.2
CAS NUMBER: 13220-57-0
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Yellow needles.
SOLUBILITY: Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING: Protect from light and moisture.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, MS and UV.

Product Description
Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. ALX-380-042) resistance on breast cancer cells.
Product Specific Literature References
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001) Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002) Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000) Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003) Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007) Abstract
General Information
Tryptanthrin occurs as a natural product in various plants, including Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria and Calanthe discolor.
Further Categories Containing This Product:
Leukotrienes Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • MDR Inhibitors • Prostaglandins Other Products • P-glycoprotein [Pgp] / Related Products • Natural Products - Nitric Oxide Pathway Modulators • COX Inhibitors
 
 
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