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Items 17 of 17
ALX-350-020 Revised 27-Aug-08
Wortmannin
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SYNONYMS KY 12420
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-020-M001   1 mg 40.00 USD Add To Cart
ALX-350-020-M005   5 mg 140.00 USD Add To Cart
ALX-350-020-M025   25 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C23H24O8
MW: 428.4
CAS NUMBER: 19545-26-7
MERCK INDEX: 14: 10053
RTECS: CB9641000
SOURCE/HOST: Isolated from Talaromyces wortmannin KY 12420.
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml), methanol (5mg/ml) or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.

Product Description
Potent and specific inhibitor of  phosphoinositide 3-kinase (PI(3)K), myosin light chain kinase and of neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D activation. Strongly inhibits autophagy (proteolysis). Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.
Product Specific Literature References
Activation of human neutrophil phospholipase D by three separable mechanisms: S.I. Reinhold, et al.; FASEB J. 4, 208 (1990) Abstract
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil: R.W. Bonser, et al.; Br. J. Pharmacol. 103, 1237 (1991) Abstract
Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors: S. Kitani, et al.; BBRC 183, 48 (1992) Abstract
Wortmannin, a microbial product inhibitor of myosin light chain kinase: S. Nakanishi, et al.; J. Biol. Chem. 267, 2157 (1992) Abstract; Full Text
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses: A. Arcaro & M.P. Wyman; Biochem. J. 296, 297 (1993) Abstract
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells: H. Yano, et al.; J. Biol. Chem. 268, 25846 (1993) Abstract; Full Text
Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes: Y. Shimizu & T. Shimazu; BBRC 202, 660 (1994) Abstract
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase: R. Woscholski, et al.; FEBS Lett. 342, 109 (1994) Abstract
Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle: A.D. Lee, et al.; FEBS Lett. 361, 51 (1995) Abstract
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption: I. Nakamura, et al.; FEBS Lett. 361, 79 (1995) Abstract
Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells: K. Tomiyama, et al.; BBRC 212, 263 (1995) Abstract
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase: M. Ui, et al.; TIBS 20, 303 (1995), (Review) Abstract
Wortmannin inhibits carcinogen-stimulated phosphorylation of ethanolamine and choline: Z. Kiss & M. Tomono; FEBS Lett. 358, 243 (1995) Abstract
Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events: O. Hazeki, et al.; J. Lipid Mediat. Cell Signal. 14, 259 (1996)
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997) Abstract
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages: Y.C. Park, et al.; BBRC 240, 692 (1997) Abstract
Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin: S.J. Liu & J.Z. Wang; Acta Pharmacol. Sin. 23, 183 (2002) Abstract
Chemistry and biology of wortmannin: P. Wipf & R.J. Halter; Org. Biomol. Chem. 3, 2053 (2005) Abstract
Further Categories Containing This Product:
Phospholipase C / Related Products • Phospholipase D / Related Products • Myosin Light Chain Kinase Inhibitors • Tau / Related Products • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products - Antifungal Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Autophagy Other Products
 
 
ALX-350-123 Revised 25-Apr-08
Eugenol (high purity)
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SYNONYMS 2-Methoxy-4-(2-propenyl)phenol (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-123-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C10H12O2
MW: 164.2
CAS NUMBER: 97-53-0
MERCK INDEX: 14: 3898
RTECS: SJ4375000
SOURCE/HOST: Isolated from clove oil, nutmeg, cinnamon and bay leaf.
APPEARANCE: Colorless to pale yellow liquid.
SOLUBILITY: Soluble in 100% ethanol, ether, oils; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: PROTECT FROM AIR!
HAZARD: HARMFUL. MAY BE CARCINOGENIC.

Product Description
TRPV1 agonist. Analgesic. Has antifungal, antimicrobial and antioxidant properties.
Product Specific Literature References
Activation of vanilloid receptor 1 (VR1) by eugenol: B.H. Yang, et al.; J. Dent. Res. 82, 781 (2003) Abstract
Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo: N. Chami, et al.; Oral. Microbiol. Immunol. 20, 106 (2005) Abstract
A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions: T. Atsumi, et al.; Toxicol. In Vitro 19, 1025 (2005) Abstract
Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats: S.A. Guenette, et al.; J. Vet. Pharmacol. Ther. 29, 265 (2006) Abstract
In vitro activity of eugenol against Candida albicans biofilms: M. He, et al.; Mycopathologia 163, 137 (2007) Abstract
Antimicrobial efficacy of eugenol microemulsions in milk against Listeria monocytogenes and Escherichia coli O157:H7: S. Gaysinsky, et al.; J. Food Prot. 70, 2631 (2007) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Analgesic / Anti-nociceptive Agents / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products - Antifungal Agents
 
 
ALX-350-139 Revised 18-Feb-08
Alternariol
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SYNONYMS AOH
3,7,9-Trihydroxy-1-methyl-6H-dibenzo(b,d)pyran-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-350-139-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C14H10O5
MW: 258.2
CAS NUMBER: 641-38-3
RTECS: HP8757000
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE MUTAGENIC.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Cholinesterase inhibitor.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis: H. Raistrick, et al.; Biochem. J. 55, 421 (1953) Abstract; Full Text
Studies in the biosynthesis of fungal metabolites. 2. The biosynthesis of alternariol and its relation to other fungal phenols: R. Thomas; Biochem. J. 78, 748 (1961) Abstract; Full Text
Effect of substrate on metabolite production of Alternaria alternata: R. Burroughs, et al.; Appl. Environ. Microbiol. 31, 685 (1976) Abstract; Full Text
Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soderhall, et al.; Appl. Environ. Microbiol. 36, 655 (1978) Abstract; Full Text
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin and F.S. Chu; Appl. Environ. Microbiol. 46, 1420 (1983) Abstract; Full Text
Alternariol, a dibenzopyrone mycotoxin of Alternaria spp., is a new photosensitizing and DNA cross-linking agent: F. DiCosmo and N.A. Straus; Experientia 41, 1188 (1985) Abstract
Nitrogen inhibition of mycotoxin production by Alternaria alternata: M. Orvehed, et al.; Appl. Environ. Microbiol. 54, 2361 (1988) Abstract; Full Text
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis and M.E. Stack; Appl. Environ. Microbiol. 60, 3901 (1994) Abstract; Full Text
The inhibitory effect of extracts from Fructus lycii and Rhizoma polygonati on in vitro DNA breakage by alternariol: D.S. Xu, et al.; Biomed. Environ. 9, 67 (1996) Abstract
Total synthesis of alternariol: K. Koch, et al.; J. Org. Chem. 70, 3275 (2005) Abstract
Mutagenicity of the mycotoxin alternariol in cultured mammalian cells: E.M. Brugger, et al.; Toxicol. Lett. 164, 221 (2006) Abstract
Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells: L. Lehmann, et al.; Food Chem. Toxicol. 44, 398 (2006) Abstract
Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro: T.J. Schrader, et al.; Mutat. Res. 606, 61 (2006) Abstract
Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51, 307 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antifungal Agents
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
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SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antifungal Agents
 
 
ALX-350-146 Revised 03-Oct-07
Neobavaisoflavone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-146-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H18O4
MW: 322.4
CAS NUMBER: 41060-15-5
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. DNA polymerase inhibitor. Shows antifungal activity.
Product Specific Literature References
Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994) Abstract
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007) Abstract
Further Categories Containing This Product:
Natural Products - DNA Replication Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Topoisomerase Inhibitors • Natural Products - Antifungal Agents • DNA Replication Inhibitors • Isoflavones
 
 
ALX-350-229 Revised 24-Jul-08
Sedanolide
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SYNONYMS 3-Butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-229-M100   100 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C12H18O2
MW: 194.1
CAS NUMBER: 6415-59-4
SOURCE/HOST: Isolated from Apium graveolens L.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or ethyl acetate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
MELTINGPOINT: 30-31°C

Product Description
Inducer of glutathione S-transferases and inhibitor of chemically induced carcinogenesis. Mosquitocidal, nematicidal and antifungal. Was shown to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2) as well as topoisomerase I and topoisomerase II.
Product Specific Literature References
Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil: G.-Q. Zheng, et al.; Nutr. Cancer 19, 77 (1993) Abstract
Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds: R.A. Momin & M.G. Nair; J. Agric. Food Chem. 49, 142 (2001) Abstract
Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines: J.A. Woods, et al.; In Vitr. Mol. Toxicol. 14, 233 (2001) Abstract
Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds: R.A. Momin & M.G. Nair; Phytomedicine 9, 312 (2002) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Antifungal Agents • Glutathione S-Transferase • Natural Products - Topoisomerase Inhibitors • Active Substances from Fruit and Vegetables • COX Inhibitors
 
 
ALX-350-294 Revised 16-Jun-08
Manzamine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-294-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C36H44N4O
MW: 548.8
CAS NUMBER: 104196-68-1
SOURCE/HOST: Isolated from Xestospongia sp.
PURITY: >98% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).
Product Specific Literature References
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996) Abstract
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000) Abstract; Full Text
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001) Abstract
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003) Abstract
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003) Abstract
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004) Abstract
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett. 8, 2591 (2006) Abstract
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antimalarial Agents • Malaria / Related Products • Natural Products with Antibiotic Activity • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antifungal Agents • Alkaloids • GSK-3 Inhibitors • Pesticides / Related Products
 
 
ALX-350-305 Revised 08-Apr-08
Tiliroside
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-305-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C30H26O13
MW: 594.5
CAS NUMBER: 20316-62-5
SOURCE/HOST: Isolated from Tilia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Flavonoid which shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages. Shows potent activity against d-GalN-induced cytotoxicity in hepatocytes. Cytotoxic against specific leukaemic cell lines. Inhibits LDL oxidation. Antibacterial and antifungal.
Product Specific Literature References
Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii: K.Y. Jung, et al.; Biol. Pharm. Bull. 21, 1077 (1998) Abstract
Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines: K. Dimas, et al.; Leuk. Res. 23, 1021 (1999) Abstract
Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action: H. Matsuda, et al.; Bioorg. Med. Chem. 10, 707 (2002) Abstract
Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside: A. Sala, et al.; Eur. J. Pharmacol. 461, 53 (2003) Abstract
Flavonoids from the leaves of Litsea japonica and their anti-complement activity: S.Y. Lee, et al.; Phytother. Res. 19, 273 (2005) Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005) Abstract; Full Text
Antiviral and antimicrobial assessment of some selected flavonoids: B. Ozcelik, et al.; Z. Naturforsch. [C] 61, 632 (2006) Abstract
Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation: G.R. Schinella, et al.; Fitoterapia 78, 1 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents • Flavonols • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antitumor Reagents • Complement System Other Products
 
 
ALX-350-348 Revised 22-Feb-08
Papuamine
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SYNONYMS (-)-Papuamine
PRODUCT LINE