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Growth, Survival and Development of Neurons
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AG-P0731 Revised 16-Oct-08
Progranulin (human) ELISA Kit
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SYNONYMS Proepithelin (human) ELISA Kit
PEPI (human) ELISA Kit
PC Cell-derived Growth Factor (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-P0731EK-KI01   96 wells 640.00 USD Add To Cart
AG-P0731TP-KI01 Twin Plex 2x96 wells 940.00 USD Add To Cart
AG-P0731PP-KI01 Penta Plex 5x96 wells 1'880.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 32pg/ml (range 0 to 8ng/ml)
SPECIFICITY: Does not cross-react with mouse and rat progranulin.
APPLICATION: For the quantitative determination of progranulin in human serum, plasma or cell culture supernatant.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008) Abstract
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J. L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
Inflammation Other Products • ELISA & EIA Kits
 
 
AG-PM0731 Revised 23-Apr-08
Progranulin (mouse) ELISA Kit
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SYNONYMS Proepithelin (mouse) ELISA Kit
PEPI (mouse) ELISA Kit
PC Cell-derived Growth Factor (mouse) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-PM0731EK-KI01   96 wells 645.00 USD Add To Cart
AG-PM0731TP-KI01 Twin Plex 2x96 wells 945.00 USD Add To Cart
AG-PM0731PP-KI01 Penta Plex 5x96 wells 1'885.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SENSITIVITY: 60pg/ml (range 0 to 16 ng/ml)
SPECIFICITY: Does not cross-react with human and rat progranulin
APPLICATION: For the quantitative determination of progranulin in mouse serum or cell culture supernatants.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
Inflammation Other Products • ELISA & EIA Kits
 
 
ALX-201-207 Revised 14-Oct-08
pro-β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS pro-β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-207-C020   20 µg 490.00 USD Add To Cart
Product Specification
MW: ~49.7kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION:

PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 7.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <0.05EU/µg protein.
BIOLOGICAL ACTIVITY: Stimulates the proliferation of TF1 cells (EC50=130±30pM).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-208 Revised 12-Feb-08
β-Nerve Growth Factor (human) (recombinant)
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SYNONYMS β-NGF (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-208-C020   20 µg 190.00 USD Add To Cart
Product Specification
MW: ~26.5kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: ~0.65mg/ml.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 7.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <0.05EU/µg protein.
BIOLOGICAL ACTIVITY: Stimulates the proliferation of TF1 cells (EC50=10.9±2.7pM).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P01138: β-Nerve Growth Factor (human)
MANUFACTURER Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-377 Revised 06-May-08
Progranulin (human) (recombinant)
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SYNONYMS Proepithelin (human) (recombinant)
PEPI (human) (recombinant)
PC Cell-derived Growth Factor (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-377-C010   10 µg 180.00 USD Add To Cart
ALX-201-377-C050   50 µg 480.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and mature human progranulin (aa 1-593) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28799: Granulins (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Inflammation Other Products
 
 
ALX-201-389 Revised 23-Apr-08
Progranulin (mouse) (recombinant)
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SYNONYMS Proepithelin (mouse) (recombinant)
PEPI (mouse) (recombinant)
PC Cell-derived Growth Factor (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-389-C010   10 µg 295.00 USD Add To Cart
ALX-201-389-C050   50 µg 690.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and mature mouse progranulin (aa 1-589) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28798: Granulins (mouse) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Related Products
Further Categories Containing This Product:
Inflammation Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-210-230 Revised 10-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor
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SYNONYMS anti-NGFR PAb
anti-TNFRSF 16 PAb
anti-p75NTR PAb
anti-p75 Neurotrophin Receptor PAb
anti-CD271 PAb
anti-Low-affinity Nerve Growth Factor Receptor PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-230-R100   100 µl 280.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to a portion of C-terminal human NGFR (nerve growth factor receptor; p75NTR).
SPECIFICITY: Recognizes human, rat and chicken NGFR.
APPLICATION: Immunoprecipitation (2µl/sample)
Western Blot (1:250-1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-921 Revised 31-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor (human) (AT101)
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SYNONYMS anti-NGFR (human) PAb (AT101)
anti-TNFRSF 16 (human) PAb (AT101)
anti-p75NTR (human) PAb (AT101)
anti-p75 Neurotrophin Receptor (human) PAb (AT101)
anti-CD271 (human) PAb (AT101)
anti-Low-affinity Nerve Growth Factor Receptor (human) PAb (AT101)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-921-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide
IMMUNOGEN: Recombinant human NGFR (nerve growth factor receptor; p75NTR) (Prod. No. ALX-522-044).
SPECIFICITY: Recognizes human NGFR.
APPLICATION: Western Blot (1:1’000)
Note: Does not work for Immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells: A. Tanaka, et al.; BBRC 313, 1009 (2004) Abstract
p75NTR--live or let die: A. Nykjaer, et al.; Curr. Opin. Neurobiol. 15, 49 (2005) Abstract
Further Categories Containing This Product:
Neurotensin / Related Products • Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-937 Revised 28-Apr-08
Polyclonal Antibody to RGMA (human) (AT115)
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SYNONYMS anti-Repulsive Guidance Molecule A (human) PAb (AT115)
anti-RGM Domain Family Member A (human) PAb (AT115)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-937-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMA (aa 48-422) (Prod. No. ALX-522-103).
SPECIFICITY: Recognizes human RGMA.
APPLICATION: Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.