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ALX-350-089
Revised 13-May-08
Croton oil
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-350-089-KI45
4.5 kg
2'400.00 USD
Product Specification
CAS NUMBER:
8001-28-3
MERCK INDEX:
14:
2598
RTECS:
GQ6300000
APPEARANCE:
Pale-yellow to brown-yellow oil.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. TOXIC.
Product Description
Natural source of phorbol and phorbol esters, purified from
Croton
tiglium L.
ALX-445-009
Revised 21-Aug-08
12-Deoxyphorbol 13-acetate
SYNONYMS
Prostratin
13-Acetyl-12-deoxyphorbol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-009-M001
1 mg
80.00 USD
ALX-445-009-M005
5 mg
320.00 USD
Product Specification
FORMULA:
C
22
H
30
O
6
MW:
390.5
CAS NUMBER:
60857-08-1
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE CARCINOGENIC. IRRITANT.
Product Description
Protein kinase C (PKC) activator that does not induce tumor formation. Upregulates latent HIV-1 provirus expression and inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle.
Product Specific Literature References
The structure of prostratin: A toxic tetracyclic diterpene ester from Pimelea prostrata.:
A.R. Cashmore, et al.; Tetrahedron Lett.
20
, 1737 (1976)
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex:
S. Zayed, et al.; Experientia
33
, 1554 (1977)
Abstract
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin:
Z. Szallasi, et al.; Cancer Res.
53
, 2507 (1993)
Abstract
Prostratin antagonizes HIV latency by activating NF-kappaB:
S.A. Williams, et al.; J. Biol. Chem.
279
, 42008 (2004)
Abstract
Prostratin as a new therapeutic agent targeting HIV viral reservoirs:
M. Hezareh; Drug News Perspect.
18
, 496 (2005), (Review)
Abstract
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells:
T. L. Sung & A. P. Rice; Retrovirology
3
, 66 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents
•
HIV / AIDS / Related Products
ALX-445-049
Revised 24-Oct-07
12-Deoxyphorbol 13-phenylacetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-049-M005
5 mg
220.00 USD
Product Specification
FORMULA:
C
28
H
34
O
6
MW:
466.6
CAS NUMBER:
58821-98-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO and ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
POTENTIAL TUMOR PROMOTER. IRRITANT.
Product Description
Metabolite of 12-deoxyphorbol 13-phenylacetate 20-acetate. Potent activator of protein kinase C (PKC). Induces the expression of HIV-1 in latently infected T cells.
Product Specific Literature References
Role of protein kinase C isozymes in activation of human immunodeficiency virus type 1 in chronically infected promonocytic cells: evidence against a role of PKC beta 1:
C.H. Kim, et al.; Biochem. Biophys. Res. Commun.
199
, 292 (1994)
Abstract
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes:
Z. Szallasi, et al.; Mol. Pharmacol.
47
, 258 (1995)
Abstract
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate:
S. Bocklandt, et al.; Antiviral Res.
59
, 89 (2003)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-020
Revised 10-Jun-03
20-Oxo-20-deoxyphorbol 12,13-dibutyrate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-020-M001
1 mg
75.00 USD
ALX-445-020-M005
5 mg
330.00 USD
Product Specification
FORMULA:
C
28
H
38
O
8
MW:
502.6
CAS NUMBER:
100930-03-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. POTENTIAL TUMOR PROMOTER.
Product Description
Used to prepare [
3
H]-PDBu.
Product Specific Literature References
Active principles of croton oil. X. Preparation of tritium labeled croton oil factor A1 and other tritium labeled phorbol derivatives
:
G. Kreibich & E. Hecker; Z. Krebsforsch.
74
, 448 (1970)
Abstract
ALX-550-371
Revised 30-Jun-08
PDDHV
SYNONYMS
Phorbol 12,13-didecanoate 20-homovanillate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-550-371-M001
1 mg
50.00 USD
ALX-550-371-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
49
H
72
O
11
MW:
837.1
CAS NUMBER:
179469-40-0
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC. IRRITANT.
Product Description
Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1 (K
i
=60nM). Tumor promotor.
Product Specific Literature References
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1:
A. Szallasi, et al.; Br. J. Pharmacol.
128
, 428 (1999)
Abstract
Further Categories Containing This Product:
Resiniferatoxin-type Phorboid Vanilloids
•
Natural Products for Neurological Research
ALX-550-372
Revised 29-Oct-07
PDNHV
SYNONYMS
Phorbol 12,13-dinonanoate 20-homovanillate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-550-372-M001
1 mg
50.00 USD
ALX-550-372-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
47
H
68
O
11
MW:
809.0
CAS NUMBER:
251362-87-5
PURITY:
≥95%
APPEARANCE:
Clear oil.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, chloroform or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TUMOR PROMOTER. IRRITANT.
Product Description
Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1.
Product Specific Literature References
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1:
A. Szallasi, et al.; Br. J. Pharmacol.
128
, 428 (1999)
Abstract
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism:
A. Macho, et al.; Chem. Biol.
7
, 483 (2000)
Abstract
Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1:
T. Ohta, et al.; Biochem. Pharmacol.
71
, 173 (2005)
Abstract
Further Categories Containing This Product:
Resiniferatoxin-type Phorboid Vanilloids
•
Natural Products for Neurological Research
ALX-445-028
Revised 08-Apr-08
Phorbol 13-acetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-028-M001
1 mg
40.00 USD
ALX-445-028-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
22
H
30
O
7
MW:
406.5
CAS NUMBER:
32752-29-7
RTECS:
QH4377000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT. MAY BE CARCINOGENIC.
Product Description
Reference compound for studying 12-deacylation of phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-003
Revised 08-Apr-08
Phorbol 12,13-diacetate
SYNONYMS
PDA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-003-M001
1 mg
20.00 USD
ALX-445-003-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
24
H
32
O
8
MW:
448.5
CAS NUMBER:
24928-15-2
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. TUMOR PROMOTER.
Product Description
Less potent than phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
), but also less hydrophobic.
Product Specific Literature References
Modulation of high-threshold Ca current and spontaneous postsynaptic transient currents by phorbol 12,13-diacetate, 1-(5-isoquinolinesulfonyl)-2-methyl piperazine (H-7), and monosialoganglioside (GM1) in CA1 pyramidal neurons of rat hippocampus in vitro:
N. Agopyan, et al.; Hippocampus
3
, 67 (1993)
Abstract
Effects of phorbol 12,13-diacetate on human isolated bronchus:
B. Sarria, et al.; Eur. J. Pharmacol.
399
, 65 (2000)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-001
Revised 08-Apr-08
Phorbol 12,13-dibutyrate
SYNONYMS
PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-001-M001
1 mg
20.00 USD
ALX-445-001-M005
5 mg
50.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
37558-16-0
RTECS:
EK7767000
PURITY:
≥99%
APPEARANCE:
Off-white to yellowish oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Widely used protein kinase C (PKC) activator. Less potent than phorbol 12-myristate 13-acetate (PMA; TPA) (Prod. No.
ALX-445-004
), but also less hydrophobic.
Product Specific Literature References
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets:
D.E. MacIntyre, et al.; FEBS Lett.
180
, 160 (1985)
Abstract
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension:
G.E. Bilder, et al.; J. Pharmacol. Exp. Ther.
252
, 526 (1990)
Abstract
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells:
T.L. Yue, et al.; Neurochem. Res.
17
, 997 (1992)
Abstract
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation:
C. Lisbona, et al.; Eur. J. Immunol.
24
, 2746 (1994)
Abstract
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line:
M.S. Johnson, et al.; Mol. Cell. Biochem.
165
, 65 (1996)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-038
Revised 08-Apr-08
4α-Phorbol 12,13-dibutyrate
SYNONYMS
4α-PDBu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-038-M001
1 mg
30.00 USD
ALX-445-038-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
28
H
40
O
8
MW:
504.6
CAS NUMBER:
93781-54-5
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TUMOR PROMOTER. HIGHLY IRRITANT.
Product Description
Negative control for phorbol 12,13-dibutyrate (PDBu) (Prod. No.
ALX-445-001
).
Product Specific Literature References
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
ALX-445-002
Revised 03-Dec-07
Phorbol 12,13-didecanoate
SYNONYMS
PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-002-M001
1 mg
20.00 USD
ALX-445-002-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
40
H
64
O
8
MW:
672.9
CAS NUMBER:
24928-17-4
RTECS:
GZ0653000
PURITY:
≥99% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HIGHLY IRRITANT. VERY TOXIC.
Product Description
Very potent and hydrophobic protein kinase C (PKC) activator.
Product Specific Literature References
Altered growth properties of normal human cells induced by phorbol 12,13-didecanoate:
R. W. Trewyn & H. B. Gatz; In Vitro
20
, 409 (1984)
Abstract
Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12,13-didecanoate. Requirement for a factor derived from early passage cells::
M. S. Elliott & J. R. Katze; J. Biol. Chem.
261
, 13019 (1986)
Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay:
L. Saraiva, et al.; Eur. J. Pharmacol.
491
, 101 (2004)
Abstract
Further Categories Containing This Product:
PKC Activators
ALX-445-006
Revised 03-Dec-07
4α-Phorbol 12,13-didecanoate
SYNONYMS
4α-PDD
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Phorbols / Phorbol Esters
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ALX-445-006-M001
1 mg
35.00 USD
ALX-445-006-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
40
H
64
O
8
MW:
672.9
CAS NUMBER:
27536-56-7
PURITY:
≥98% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.
HANDLING:
Protect from light.
HAZARD:
HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Activator of TRPV4. Negative control for phorbol 12,13-didecanoate (PDD) (Prod. No.
ALX-445-002
).
Product Specific Literature References
TRPV4 calcium entry channel: a paradigm for gating diversity
:
B. Nilius, et al.;
