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ALX-270-055
Revised 07-Dec-04
Bisindolylmaleimide VII
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
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ALX-270-055-M001
1 mg
45.00 USD
ALX-270-055-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
27
N
5
O
2
MW:
453.5
CAS NUMBER:
137592-47-3
PURITY:
≥96%
APPEARANCE:
Orange solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-056
Revised 18-Jan-08
Bisindolylmaleimide VIII . acetate
SYNONYMS
Ro 31-7549 . acetate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-056-M001
1 mg
45.00 USD
ALX-270-056-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
24
H
22
N
4
O
2
. CH
3
COOH
MW:
398.5 . 60.1
CAS NUMBER:
138516-31-1
PURITY:
≥98%
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Specific Literature References
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
:
T. Zhou, et al.; Nat. Med.
5
, 42 (1999)
Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways
:
T. Ohtsuka & T. Zhou; J. Biol. Chem.
277
, 29294 (2002)
Abstract
;
Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-057
Revised 18-Jan-08
Bisindolylmaleimide X . hydrochloride
SYNONYMS
Ro 31-8425 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-057-M001
1 mg
45.00 USD
ALX-270-057-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
26
H
24
N
4
O
2
. HCl
MW:
424.5 . 36.5
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-058
Revised 28-May-08
Bisindolylmaleimide XI . hydrochloride
SYNONYMS
Ro 32-0432 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-058-M001
1 mg
45.00 USD
ALX-270-058-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
28
H
28
N
4
O
2
. HCl
MW:
452.6 . 36.5
PURITY:
≥98% (NMR)
APPEARANCE:
Orange to brown red solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-069
Revised 04-Feb-05
HA-100 . dihydrochloride
SYNONYMS
1-(5-Isoquinolinylsulfonyl)piperazine . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
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ALX-270-069-M005
5 mg
40.00 USD
Product Specification
FORMULA:
C
13
H
15
N
3
O
2
S . 2HCl
MW:
277.3 . 73.0
CAS NUMBER:
84468-24-6
PURITY:
≥99%
APPEARANCE:
Lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of myosin light chain kinase, cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).
Product Specific Literature References
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor:
C. Gerard, et al.; J. Clin. Invest.
77
, 61 (1986)
Abstract
Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives:
M. Hagiwara, et al.; Mol. Pharmacol.
32
, 7 (1987)
Abstract
Further Categories Containing This Product:
PKC Inhibitors
•
Myosin Light Chain Kinase Inhibitors
ALX-270-081
Revised 20-Dec-02
MDL-27,032
SYNONYMS
4-Propyl-5-(4-pyridinyl)-2(3
H
)-oxazolone
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
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ALX-270-081-C100
100 µg
50.00 USD
ALX-270-081-M001
1 mg
200.00 USD
Product Specification
FORMULA:
C
11
H
12
N
2
O
2
MW:
204.2
PURITY:
≥97%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent vasodilator. Inhibitor of protein kinase C and cAMP-dependent protein kinase (PKA). Inhibition is competitive with ATP and not competitive with phospholipid, diacylglycerol, phorbol ester and calcium.
Product Specific Literature References
MDL 27,032 [4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone], an active site- directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle:
P.J. Robinson, et al.; J. Pharmacol. Exp. Ther.
255
, 1392 (1990)
Abstract
Further Categories Containing This Product:
PKA Inhibitors
ALX-270-084
Revised 28-Jan-05
ML-9 . hydrochloride
SYNONYMS
1-(5-Chloronaphthalene-1-sulfonyl)-1
H
-hexahydro-1,4-diazepine . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
Ordering Information
Product Numbers:
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ALX-270-084-M010
10 mg
65.00 USD
ALX-270-084-M025
25 mg
125.00 USD
Product Specification
FORMULA:
C
15
H
17
ClN
2
O
2
S . HCl
MW:
324.8 . 36.5
CAS NUMBER:
105637-50-1
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibitor of myosin light chain kinase, protein kinase C (PKC) and protein cAMP-dependent protein kinase (PKA). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Product Specific Literature References
The modulatory role of myosin light chain phosphorylation in human platelet activation [published erratum appears in Biochem Biophys Res Commun 1987 Jan 15;142(1):287]:
M. Saitoh, et al.; BBRC
140
, 280 (1986)
Abstract
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells:
T. Nagatsu, et al.; BBRC
143
, 1045 (1987)
Abstract
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase:
M. Saitoh, et al.; J. Biol. Chem.
262
, 7796 (1987)
Abstract
;
Full Text
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle:
M. Seto, et al.; Eur. J. Pharmacol.
195
, 267 (1991)
Abstract
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells:
J.A. Reig, et al.; Neurochem. Res.
18
, 317 (1993)
Abstract
Further Categories Containing This Product:
PKC Inhibitors
•
PKA Inhibitors
•
Myosin Light Chain Kinase Inhibitors
ALX-270-088
Revised 07-Apr-05
ML-7 . hydrochloride
SYNONYMS
1-(5-Iodonaphthalene-1-sulfonyl)-1
H
-hexahydro-1,4-diazepine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-270-088-M005
5 mg
40.00 USD
ALX-270-088-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
17
IN
2
O
2
S . HCl
MW:
416.0 . 36.5
CAS NUMBER:
110448-33-4
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (can be further diluted with water), 100% ethanol (warm) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits smooth-muscle myosin light chain kinase, protein kinase C (PKC), and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase:
M. Saitoh, et al.; J. Biol. Chem.
262
, 7796 (1987)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Inhibitors
•
PKA Inhibitors
•
Myosin Light Chain Kinase Inhibitors
ALX-270-097
Revised 07-Sep-06
Ebselen
SYNONYMS
2-Phenyl-1,2-benzisoselenazol-3-(2
H
)-one
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers:
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ALX-270-097-M001
1 mg
12.00 USD
ALX-270-097-M005
5 mg
20.00 USD
ALX-270-097-M025
25 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
9
NOSe
MW:
274.2
CAS NUMBER:
60940-34-3
PURITY:
≥98% (NMR)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages
:
M.J. Parnham & S. Kindt; Biochem. Pharmacol.
33
, 3247 (1984)
Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
:
M.J. Parnham & E. Graf; Biochem. Pharmacol.
36
, 3095 (1987)
Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)
:
M. Maiorino, et al.; Biochem. Pharmacol.
37
, 2267 (1988)
Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?:
I.A. Cotgreave, et al.; Biochem. Pharmacol.
38
, 649 (1989)
Abstract
T. Nikawa, et al.; Biochem. Pharmacol.
47
, 1007 (1994)
Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals:
N. Noguchi, et al.; Biochim. Biophys. Acta
1213
, 176 (1994)
Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione:
C. Schewe, et al.; Biochem. Pharmacol.
48
, 65 (1994)
Abstract
Ebselen: a glutathione peroxidase mimic
:
H. Sies; Meth. Enzymol.
234
, 476 (1994)
Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant
:
T. Schewe; Gen. Pharmacol.
26
, 1153 (1995)
Abstract
Ebselen
:
H. Sies; Meth. Enzymol.
252
, 341 (1995)
Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite
:
H. Sies & H. Masumoto; Adv. Pharmacol.
38
, 229 (1997)
Abstract
Free radical generation by selenium compounds and their prooxidant toxicity
:
J.E. Spallholz; Biomed. Environ. Sci.
10
, 260 (1997)
Abstract
Protection against peroxynitrite by selenoproteins
:
H. Sies, et al.; Z. Naturforsch. [C]
53
, 228 (1998)
Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury
:
G. Tiegs, et al.; J. Pharmacol. Exp. Ther.
287
, 1098 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
PKC Inhibitors
•
Malaria / Related Products
•
Lipoxygenases / Related Products
•
Anti-inflammatory Agents Other Products
•
COX Inhibitors
ALX-270-104
Revised 21-Mar-07
NPC-15437 . dihydrochloride
SYNONYMS
(S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-270-104-M001
1 mg
90.00 USD
ALX-270-104-M005
5 mg
350.00 USD
Product Specification
FORMULA:
C
25
H
50
N
4
O
2
. 2 HCl
MW:
438.7 . 73.0
CAS NUMBER:
136449-85-9; 141774-20-1
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water, DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mu
