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Bcl-2 Family Members / Related Products
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Mitochondrial Pathway > Bcl-2 Family Members / Related Products
 
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ALX-152-027 Revised 14-Jul-08
BimL (147-164) (human) (cell permeable)
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SYNONYMS BCL2L11 (147-164) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bim / Related Products
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ALX-152-027-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-WIAQELRRIGDEFNAYYA-amide
FORMULA: C161H261N61O41
MW: 3707.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Peptides
 
 
ALX-152-028 Revised 14-Jul-08
Bax (58-75) (human) (cell permeable)
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SYNONYMS BCL2L4 (58-75) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bax / Related Products
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ALX-152-028-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-KLSECLKRIGDELDSNME-amide
FORMULA: C144H260N58O44S2
MW: 3572.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Further Categories Containing This Product:
Peptides
 
 
ALX-152-029 Revised 14-Jul-08
Bok (66-83) (human) (cell permeable)
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SYNONYMS NBK (66-83) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-152-029-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-EVCTVLLRLGDELEQIRP-amide
FORMULA: C149H269N59O41S
MW: 3575.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
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Further Categories Containing This Product:
Peptides
 
 
ALX-158-011 Revised 12-Sep-05
Humanin (human)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
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ALX-158-011-MC05   0.5 mg 210.00 USD Add To Cart
ALX-158-011-M001   1 mg 350.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
FORMULA: C119H204N34O32S2
MW: 2687.3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein [1]. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function [1-3]. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin [4]. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Product Specific Literature References
[1] A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta: Y. Hashimoto, et al.; PNAS 98, 6336 (2001) Abstract; Full Text
[2] Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults: Y. Hashimoto, et al.; J. Neurosci. 21, 9235 (2001) Abstract; Full Text
[3] Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein: Y. Hashimoto, et al.; BBRC 283, 460 (2001) Abstract
[4] Humanin peptide suppresses apoptosis by interfering with Bax activation: B. Guo, et al.; Nature 423, 456 (2003) Abstract
Further Categories Containing This Product:
Peptides • Bcl-2 Family Interacting Proteins / Related Products
 
 
ALX-165-067 Revised 16-May-06
PUMA (135-154) (cell permeable)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Noxa & PUMA / Related Products
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ALX-165-067-1   1 Vial 240.00 USD Add To Cart
Product Specification
SEQUENCE: REIGAQLRRMADDLNAQYER-GG-rrrqrrkkr-G-amide
FORMULA: C158H276N68O45S
MW: 3897.4
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
POSITIVE CONTROL: Prod. No. ALX-168-010
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
BH3-Only proteins-essential initiators of apoptotic cell death: D.C. Huang and A. Strasser; Cell 103, 839 (2000) Abstract
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Peptides
 
 
ALX-201-111 Revised 03-Mar-05
tBid (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
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ALX-201-111-C020   20 µg 230.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Truncated C-terminal human Bid (aa 61-195) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE). Affinity purified
FORMULATION: Liquid. In PBS.
BIOLOGICAL ACTIVITY: Facilitates Bax oligomerization and induces cytochrome c release in isolated mitochondria (~10-50ng/ml).
APPLICATION: Studies of Bid/Bax interaction and in vitro cytochrome c release.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
General Information
Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems. Bid action has been proposed to involve the mitochondrial re-location of its truncated from tBid, to facilitate the release of apoptogenic proteins like cytochrome c.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P55957: Bid (human)
AfCS Signalling Gateway link A002558: Bid (mouse)
General Literature References
Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes: X.M. Yin; J. Mol. Med. 78, 203 (2000) Abstract
The roles of Bid: M.D. Esposti; Apoptosis 7, 433 (2002) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-210-001 Revised 29-Jun-05
Polyclonal Antibody to A1 (mouse)
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SYNONYMS anti-Bfl-1 (mouse) PAb
anti-Bcl-2-related Protein A1 (mouse) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-210-001-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 34-51 (C34RVLQRVAFSVQKEVEKN51) of mouse Bcl-2-related protein A1.
SPECIFICITY: Recognizes mouse A1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation: E.Y. Lin, et al.; Blood 87, 983 (1996) Abstract; Full Text
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Polyclonal Antibodies
 
 
ALX-210-002 Revised 29-Jun-05
Polyclonal Antibody to Bak
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SYNONYMS anti-BCL2L7 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-210-002-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-36 (C14GEPALPSASEEQVAQDTEEVFR36) of human Bak.
SPECIFICITY: Recognizes human, mouse and rat Bak. Detects a band of ~24kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot (1-2µl/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
Product Specific Literature References
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas: M. Krajewska, et al.; Cancer Res. 56, 2422 (1996) Abstract
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family: S. Krajewski, et al.; Cancer Res. 56, 2849 (1996) Abstract
Increased intestinal Bak expression results in apoptosis: S.F. Moss, et al.; BBRC 223, 199 (1996) Abstract
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth: S. Krajewski, et al.; Cell Death Differ. 5, 408 (1998) Abstract
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1: I.M. Pedersen, et al.; Blood 100, 1795 (2002) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-003 Revised 29-Jun-05
Polyclonal Antibody to Bax
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SYNONYMS anti-BCL2L4 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bax / Related Products
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ALX-210-003-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 43-61 (P43ELTLEQPPQDASTKKLSE61) of mouse Bax. This sequence is completely conserved in rat Bax.
SPECIFICITY: Recognizes human, mouse and rat Bax.
APPLICATION: Immunohistochemistry (frozen sections, paraffin sections (1:500-1:2'000))
Immunoprecipitation (1µl/106 cells)
Western Blot (1:500-1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
Product Specific Literature References
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2: S. Krajewski, et al.; Am. J. Pathol. 145, 1323 (1994) Abstract
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal: H.E. Broome, et al.; J. Immunol. 155, 2311 (1995) Abstract
Upregulation of bax protein levels in neurons following cerebral ischemia: S. Krajewski, et al.; J. Neurosci. 15, 6364 (1995) Abstract
Overexpression of the Bcl-2 protein increases the half-life of p21Bax: T. Miyashita, et al.; J. Biol. Chem. 270, 26049 (1995) Abstract; Full Text
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis: R.C. Humphreys, et al.; Development 122, 4013 (1996) Abstract; Full Text
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth: S. Krajewski, et al.; Cell Death Differ. 5, 408 (1998) Abstract
Bax cleavage is mediated by calpain during drug-induced apoptosis: D.E. Wood, et al.; Oncogene 17, 1069 (1998) Abstract
Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis: J.E. Kim, et al.; J. Neurochem. 72, 2456 (1999) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-004 Revised 29-Jun-05
Polyclonal Antibody to Bcl-XL/S (1695)
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SYNONYMS anti-BCL2L1 PAb (1695)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
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ALX-210-004-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 46-66 (E46TPSAINGNPSWHLADSPAVN66) of human Bcl-X. This sequence is completely conserved in mouse, rat and pig Bcl-X.
SPECIFICITY: Recognizes human and mouse Bcl-XL and Bcl-XS.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Immunohistochemical analysis of in vivo patterns of Bcl-X expression: S. Krajewski, et al.; Cancer Res. 54, 5501 (1994) Abstract
High expression of the bcl-x gene in Reed-Sternberg cells of Hodgkin's disease: D. Schlaifer, et al.; Blood 85, 2671 (1995) Abstract; Full Text
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse: S.H. Kaufmann, et al.; Blood 91, 991 (1998) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-005 Revised 21-Aug-07
Polyclonal Antibody to Bcl-XL/S (1688)
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SYNONYMS anti-BCL2L1 PAb (1688)