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Neurobiology
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ALX-210-460 Revised 26-Apr-07
Polyclonal Antibody to Nucleobindin-2 (mouse)
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SYNONYMS anti-NUCB2 (mouse) PAb
anti-DNA-binding Protein NEFA (mouse) PAb
anti-Nesfatin (mouse) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Signalling (Intracellular) Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-460-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse nucleobindin-2 (NUCB2).
SPECIFICITY: Recognizes mouse nucleobindin-2.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Nesfatin / Related Products • Polyclonal Antibodies
 
 
ALX-210-462 Revised 10-Apr-08
Polyclonal Antibody to TRB-3 (human)
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SYNONYMS anti-Tribbles Homolog 3 (human) PAb
anti-Neuronal Cell Death-inducible Putative Kinase (human) PAb
anti-p65-interacting Inhibitor of NF-κB (human) PAb
anti-SINK (human) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Modulators
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ALX-210-462-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 112-125 (A112RLPPHKHVARPTE125) of human TRB-3 (tribbles homolog 3).
SPECIFICITY: Recognizes human TRB-3.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry (paraffin sections(1:500))
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPARγ, a master regulator of adipocyte differentiation, and to control adipogenesis.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
PPAR Other Products • PI(3)K-Akt-mTOR Pathway Other Products • MAPK Pathway Other Products • Polyclonal Antibodies • Transcription Regulators Other Products
 
 
ALX-210-531 Revised 30-Oct-06
Polyclonal Antibody to Ghrelin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-210-531-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to human Ghrelin (G1SSFLSPEHQRVQQRKESKKPPAKLPQR28).
SPECIFICITY: Recognizes human ghrelin. Detects a band of ~3kDa by Western blot. Detects both octanoylated and non-octanoylated forms of ghrelin.
APPLICATION: Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-534 Revised 27-Dec-06
Polyclonal Antibody to Akt (mouse)
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SYNONYMS anti-PKB (mouse) PAb
anti-Protein Kinase B (mouse) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Akt [PKB] / Related Products
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ALX-210-534-R100   100 µl 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse Akt (protein kinase B; PKB).
SPECIFICITY: Recognizes mouse Akt. Does not cross-react with other species.
APPLICATION: ELISA
Immunoprecipitation (5µl/700µl protein extracts)
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Phospho-specific Antibodies • Polyclonal Antibodies
 
 
ALX-210-560 Revised 29-Nov-04
Polyclonal Antibody to Dopamine-β-hydroxylase
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SYNONYMS anti-DBH PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors / Related Products
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ALX-210-560-R250   250 µl 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From sheep.
FORMULATION: Liquid. Neat serum containing 0.2% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 43-62 (S43EPPESPFPY
HIPLDPEGTL62) of N-terminal rat DBH (dopamine-β-hydroxylase). This sequence is highly conserved (>85% homology) in human, bovine and mouse DBH.
SPECIFICITY: Recognizes rat DBH. Specifically stains chromaffin cells of the adrenal medulla and DBH-containing cells of the sympathetic nervous system, including locus coeruleus and medulla oblongata. Cross-reactivity with other species has not been tested, but broad species cross-reactivity is expected due to conservation of the immunogenic sequence.
APPLICATION: Immunocytochemistry (1:5'000-1:10'000)
Immunohistochemistry (frozen sections (1:20'000-1:50'000))
Western Blot (1:5'000-1:10'000 by ECL detection)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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General Information
Dopamine-β-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to noradrenaline. Tissue specificity consists of chromaffin granules of the adrenal medulla and synaptic vesicles of the sympathetic nervous system. It exists as both, a soluble and membrane-bound form in chromaffin granules.
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-210-561 Revised 27-Dec-06
Polyclonal Antibody to Nicastrin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY gamma-Secretase Protein Complex / Related Products
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ALX-210-561-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 688-708 (C688INAKADVLFIAPREPGAVSY708) of human nicastrin.
SPECIFICITY: Recognizes human and mouse nicastrin. Detects a band of ~110kDa by Western blot.
APPLICATION: Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod No. ALX-163-014.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-562 Revised 21-Dec-06
Polyclonal Antibody to Presenilin 1
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Presenilin / Related Products
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ALX-210-562-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From chicken.
CONCENTRATION: 1mg/ml.
FORMULATION: PEG purified antibody in PBS containing 1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 311-322 (K311NSKYNAESTER322) and aa 342-353 (E342AQRDSHLGPHR353) of human presenilin 1.
SPECIFICITY: Recognizes human, mouse and rat presenilin 1. Detects a band of ~66kDa by Western blot.
APPLICATION: Western Blot (1µg/ml)

Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
gamma-Secretase Protein Complex / Related Products • Polyclonal Antibodies
 
 
ALX-210-563 Revised 20-Mar-06
Polyclonal Antibody to Presenilin 2
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Presenilin / Related Products
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ALX-210-563-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From chicken.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: PEG purified IgY.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 319-330 (Y319DPENEEDSYDS330) and aa 349-360 (G349EELEEEEERGV360) of human presenilin 2.
SPECIFICITY: Recognizes human, mouse and rat presenilin 2. Detects a band of ~66kDa by Western blot.
APPLICATION: Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
gamma-Secretase Protein Complex / Related Products • Polyclonal Antibodies
 
 
ALX-210-573 Revised 28-Sep-07
Polyclonal Antibody to Myelin Basic Protein
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SYNONYMS anti-Myelin Basic Protein PAb
Polyclonal Antibody to MBP
anti-MBP PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-210-573-1   1 Vial 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 500µl of sterile distilled water.
IMMUNOGEN: Human myelin basic protein (Prod. No. ALX-200-606).
SPECIFICITY: Recognizes human, mouse and bovine myelin basic protein.
APPLICATION: ELISA
Immunohistochemistry
Western Blot (1:100-1:200)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Reconstituted antibody is stable for at least 6 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Related Products
Further Categories Containing This Product:
PKC Substrates • Polyclonal Antibodies
 
 
ALX-210-701 Revised 29-Mar-05
Polyclonal Antibody to Bcl-2
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 / Related Products
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ALX-210-701-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. Purified antibody in 0.05M sodium phosphate buffer containing 0.2% gelatin and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 20-34 of human Bcl-2.
SPECIFICITY: Recognizes human, mouse and opossum Bcl-2. This antibody is particularly useful for the determination of Bcl-2 expression levels in species other than human.
APPLICATION: Immunohistochemistry:
Frozen sections: 5µg/ml; no pre-treatment needed.
Paraffin sections: 2.5µg/ml; pressure cooker antigen retrieval is recommended.
For both: DAB detection. Intestine or human lymph node can be used as positive control, brain tissue as negative control (only random cells will stain for Bcl-2 in brain tissue).
Western Blot: 5µg/ml; ECL detection. MCF-7 cells can be used as a positive control, normal rabbit IgG as negative control.
Titration is recommended for optimal results in individual systems.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-702 Revised 21-Aug-07
Polyclonal Antibody to Bcl-XL/S
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SYNONYMS anti-BCL2L PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
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ALX-210-702-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. In 0.05M sodium phosphate buffer containing 0.09% sodium azide and 0.2% gelatin.
IMMUNOGEN: Synthetic peptide corresponding to aa 201-216 of human Bcl-X.
SPECIFICITY: Recognizes human, mouse, rat and opossum Bcl-XL (strongly) and Bcl-XS (moderately).
APPLICATION: Immunohistochemistry:
Frozen sections: 5µg/ml; no pre-treatmant needed; mouse and rat frozen intestinal tissue was fixed with Zamboni’s fixative prior to staining.
Paraffin sections: 2.5µg/ml; pressure cooker antigen retrieval is recommended.
Western Blot: 2.5µg/ml; chemiluminescent detection. Positive control tested was MCF-7 cells stimulated for 72 hours with 0.2µg/ml doxorubicin; normal rabbit IgG as negative control. Human samples only!
Titration is recommended for optimal results in individual systems.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis: G. Cao, et al.; J. Neurosci. 22, 5423 (2002) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-708 Revised 30-Jun-06
Polyclonal Antibody to 14-3-3 (human)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
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ALX-210-708-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human